TAK1 associated with the CBM complex phosphorylates IKKbeta

Stable Identifier
R-HSA-1168641
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.

Literature References
PubMed ID Title Journal Year
16301747 PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

Shinohara, H, Yasuda, T, Aiba, Y, Sanjo, H, Hamadate, M, Watarai, H, Sakurai, H, Kurosaki, T

J Exp Med 2005
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C, Deng, L, Hong, M, Akkaraju, GR, Inoue, J, Chen, ZJ

Nature 2001
20449947 Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes

Zhang, W, Zhang, X, Wu, XL, He, LS, Zeng, XF, Crammer, AC, Lipsky, PE

Chin Med Sci J 2010
19909372 Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling

Shinohara, H, Kurosaki, T

Immunol Rev 2009
14695475 Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

Zhou, H, Wertz, I, O'Rourke, K, Ultsch, M, Seshagiri, S, Eby, M, Xiao, W, Dixit, VM

Nature 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed