Reactome: A Curated Pathway Database

CARMA1 recruits MALT1 and BCL10 forming CBM Complex

Stable Identifier
R-HSA-1168644
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Formation of CBM Complex
Locations in the PathwayBrowser
Summation

CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).

Literature References
Participants
Participant Of
Orthologous Events