Reactome: A Curated Pathway Database

JAK2 phosphorylates STAT1/STAT3

Stable Identifier
R-HSA-1168767
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GH stimulated tyrosyl phosphorylation of Stats 1, 3, and 5 in CHO cells expressing GHR constructs that bind JAK2 but not in CHO cells expressing GHR constructs that do not bind JAK2 (Smit et al. 1996). STAT5 phosphorylation was greatly reduced in GHR mutants with the distal region of the cytoplasmic tail removed and by mutation of distal GHR tyrosine residues to phenylalanine but this had no effect on STAT1/STAT3 phosphorylation, suggesting that the latter interact with JAK2 directly.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
non-membrane spanning protein tyrosine kinase activity of Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane] Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane] non-membrane spanning protein tyrosine kinase activity (0004715)
Inferred From