Reactome: A Curated Pathway Database

Metalloprotease cleavage of GHR

Stable Identifier
R-HSA-1168777
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Approximately half of circulating GH is bound to Growth Hormone Binding Protein ((GHBP) Herington et al. 1986), a soluble fragment of the Growth Hormone Receptor (Baumann et al. 1986) formed when the extracellular region is proteolytically cleaved (Leung et al. 1987). This cleavage is mediated by metalloproteases such as TACE (ADAM17, Zhang et al. 2000). The membrane-bound remnant is subsequently degraded by the gamma-secretase complex (Cowan et al. 2005).

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metalloendopeptidase activity of ADAM17 [plasma membrane] ADAM17 [plasma membrane] metalloendopeptidase activity (0004222)
Inferred From