Reactome: A Curated Pathway Database

SHP1 (PTPN6) binds JAK2 in the receptor complex

Stable Identifier
R-HSA-1168839
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SHP1 binds GH-activated JAK2 and controls the duration of GH-dependent JAK2 phosphorylation in the liver, consequently hepatic GH signaling is prolonged in mice lacking SHP1 (Hackett et al. 1999).

Participants
Participant Of
Inferred From