SHP1 (PTPN6) binds JAK2 in the receptor complex

Stable Identifier
R-HSA-1168839
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SHP1 binds GH-activated JAK2 and controls the duration of GH-dependent JAK2 phosphorylation in the liver, consequently hepatic GH signaling is prolonged in mice lacking SHP1 (Hackett et al. 1999).

Participants
Participant Of
Inferred From
Authored
Reviewed
Created