Reactome: A Curated Pathway Database

p-STAT5A/B dissociates from the Growth Hormone receptor

Stable Identifier
R-HSA-1168894
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believed to occur following release of the phosphorylated monomers from the receptor complex and is typically represented in this manner (e.g. Turkson & Jove 2000).

Literature References
Participants
Participant Of
Orthologous Events