Reactome | p-Y771,Y783-PLCG1 [plasma membrane]

p-Y771,Y783-PLCG1 [plasma membrane]

Stable Identifier

R-HSA-1169084

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y771,Y783-PLCG1(1-1290), Phospholipase C gamma 1 phosphorylated at Tyr-771 and Tyr-783, Phospho-PLC gamma 1

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Literature References

PubMed ID	Title	Journal	Year
15161916	Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation Sekiya, F, Poulin, B, Kim, YJ, Rhee, SG	J Biol Chem	2004

External Reference Information

External Reference

UniProt:P19174 PLCG1

Gene Names

PLCG1, PLC1

Chain

initiator methionine:1, chain:2-1290

Reference Genes

BioGPS Gene:5335 PLCG1

COSMIC (genes):PLCG1 PLCG1

CTD Gene:5335 PLCG1

dbSNP Gene:5335 PLCG1

ENSEMBL:ENSG00000124181 PLCG1

HGNC:9065 PLCG1

KEGG Gene (Homo sapiens):5335 PLCG1

Monarch:5335 PLCG1

NCBI Gene:5335 PLCG1

OMIM:172420 PLCG1

UCSC:P19174 PLCG1

Reference Transcript

Other Identifiers

0006100026

1082_at

11723761_a_at

11723762_at

16913761

16913806

202789_at

216551_x_at

240805_at

34351_at

3885545

3885546

3885547

3885548

3885559

3885560

3885561

3885563

3885564

3885566

3885568

3885569

3885570

3885571

3885572

3885573

3885574

3885576

3885577

3885578

3885581

3885582

3885583

3885585

3885587

3885588

3885589

3885590

3885591

3885595

3885596

3885597

3885600

3885602

3885603

3885604

3885606

3885607

3885608

3885609

3885610

3885611

3885612

3885613

3885614

3885615

3885616

3885617

3885618

3885619

3885620

3885621

3885623

3885624

5335

8062623

81996_at

A_14_P119146

A_14_P134037

GE537103

GE81175

GE88032

GO:0000902

GO:0001701

GO:0001726

GO:0002376

GO:0003674

GO:0004435

GO:0004629

GO:0005168

GO:0005509

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006629

GO:0006810

GO:0007165

GO:0007173

GO:0007202

GO:0007411

GO:0008081

GO:0008150

GO:0008180

GO:0008219

GO:0008283

GO:0009056

GO:0009395

GO:0009790

GO:0010634

GO:0010863

GO:0016032

GO:0016042

GO:0016192

GO:0016477

GO:0016787

GO:0019722

GO:0019899

GO:0019901

GO:0030027

GO:0030154

GO:0030971

GO:0032991

GO:0035254

GO:0035556

GO:0038095

GO:0038096

GO:0040011

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043536

GO:0043647

GO:0044281

GO:0044403

GO:0045766

GO:0046872

GO:0048646

GO:0048856

GO:0048870

GO:0050852

GO:0050900

GO:0051281

GO:0055085

GO:0071364

GO:1905564

GO:2000353

Hs.161402.0.A1_3p_at

Hs.268177.0.S2_3p_at

Hs.268177.1.S1_3p_a_at

ILMN_1740160

ILMN_2382906

M34667_at

PH_hs_0027331

TC20000303.hg

Participant Of

hasMember

p-PLC gamma1,2 [plasma membrane]

Other forms of this molecule

p-4Y-PLCG1 [plasma membrane]

p-Y771,Y783,Y1254-PLCG1 [cytosol]

PLCG1 [cytosol]

PLCG1 [plasma membrane]

p-Y-PLCG1 [cytosol]

Inferred To

phospho-plcg1 [plasma membrane] (Danio rerio)

phospho-plcg1 [plasma membrane] (Xenopus tropicalis)

phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Sus scrofa)

phospho-PLCG1 [plasma membrane] (Canis familiaris)

phospho-Plcg1 [plasma membrane] (Mus musculus)

phospho-Plcg1 [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 771

Coordinate

771

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 783

Coordinate

783

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_877963.1, NP_002651.2

OpenTargets

ENSG00000124181

GeneCards

P19174

HPA

ENSG00000124181-PLCG1

ZINC - Substances

PLCG1_HUMAN

Ensembl

ENSP00000362368, ENSP00000244007, ENSG00000124181, ENST00000373271, ENST00000244007

ZINC target

P19174

PRO

P19174

ZINC - Predictions - Purchasable

PLCG1_HUMAN

PDB

1HSQ, 4FBN, 4EY0, 2HSP

HMDB Protein

HMDBP00244

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	8	FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.872	9
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.85	6
UniProt:P09619 PDGFRB	3	PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.822	6
UniProt:O43561 LAT	3	LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.81	7
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.799	9
UniProt:P10721 KIT	111	KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT C443Y [plasma membrane] (R-HSA-9680045) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617) p7Y-KIT N822D [plasma membrane] (R-HSA-9669613) p7Y-KIT N822S [plasma membrane] (R-HSA-9669614) p-7Y KIT V654E [plasma membrane] (R-HSA-9669615) p7Y-KIT N822I [plasma membrane] (R-HSA-9669608) p7Y-KIT D816N [plasma membrane] (R-HSA-9669611) p7Y-KIT A829P [plasma membrane] (R-HSA-9669605) p7Y-KIT D816H [plasma membrane] (R-HSA-9669606) p6Y-KIT Y823C [plasma membrane] (R-HSA-9669607) p7Y-KIT K642Q [plasma membrane] (R-HSA-9669601) p6Y-KIT Y823N [plasma membrane] (R-HSA-9669597) p7Y-KIT D816A [plasma membrane] (R-HSA-9669629) p7Y-KIT N822H [plasma membrane] (R-HSA-9669598) p7Y-KIT D816F [plasma membrane] (R-HSA-9671513) p-7Y KIT V654A [plasma membrane] (R-HSA-9669593) p7Y-KIT N822T [plasma membrane] (R-HSA-9669622) p7Y-KIT D816E [plasma membrane] (R-HSA-9671510) p7Y-KIT D816Y [plasma membrane] (R-HSA-9669623) p7Y-KIT N822Y [plasma membrane] (R-HSA-9669619) p7Y-KIT V559D [plasma membrane] (R-HSA-9669620) p7Y-KIT K550I P551_V555del [plasma membrane] (R-HSA-9669602) p-7Y KIT W557_K558del [plasma membrane] (R-HSA-9670352) p-5Y KIT V560_L576del [plasma membrane] (R-HSA-9670348) p7Y-KIT L576P [plasma membrane] (R-HSA-9669616) p7Y-KIT V559_V560del [plasma membrane] (R-HSA-9669618) p7Y-KIT P551_V555del [plasma membrane] (R-HSA-9669621) p7Y-KIT V560G [plasma membrane] (R-HSA-9669610) p7Y-KIT K550_K558del [plasma membrane] (R-HSA-9669624) p7Y-KIT V560E [plasma membrane] (R-HSA-9669603) p7Y-KIT V560D [plasma membrane] (R-HSA-9669626) p7Y-KIT V559A [plasma membrane] (R-HSA-9669625) p7Y-KIT V559I [plasma membrane] (R-HSA-9669609) p7Y-KIT W557R [plasma membrane] (R-HSA-9669627) p7Y-KIT V559G [plasma membrane] (R-HSA-9669600) p7Y-KIT W557G [plasma membrane] (R-HSA-9669604) p7Y-KIT K509I [plasma membrane] (R-HSA-9680180) p7Y-KIT A502_Y503dup [plasma membrane] (R-HSA-9680120) p7Y-KIT S476I [plasma membrane] (R-HSA-9680156) p7Y-KIT C443Y [plasma membrane] (R-HSA-9680138) p7Y-KIT D419A [plasma membrane] (R-HSA-9680129) p7Y-KIT T417-D419delinsY [plasma membrane] (R-HSA-9680165) p7Y-KIT D419H [plasma membrane] (R-HSA-9680132) p7Y-KIT S501_A502dup [plasma membrane] (R-HSA-9680161) p7Y-KIT D419del [plasma membrane] (R-HSA-9680127) p7Y-KIT N505_F508dup [plasma membrane] (R-HSA-9680159) p7Y-KIT D419N [plasma membrane] (R-HSA-9680134) p7Y-KIT C443S [plasma membrane] (R-HSA-9680137) p7Y-KIT S476N [plasma membrane] (R-HSA-9680158) p7Y-KIT D419G [plasma membrane] (R-HSA-9680130) KIT A829P [plasma membrane] (R-HSA-9669426) KIT N822D [plasma membrane] (R-HSA-9669447) KIT V654E [plasma membrane] (R-HSA-9669576) KIT W557R [plasma membrane] (R-HSA-9669581) KIT W557G [plasma membrane] (R-HSA-9669578) KIT V559A [plasma membrane] (R-HSA-9669547) KIT K550I P551_V555del [plasma membrane] (R-HSA-9669444) KIT L576P [plasma membrane] (R-HSA-9669446) KIT V559_V560del [plasma membrane] (R-HSA-9669561) KIT P551_V555del [plasma membrane] (R-HSA-9669433) KIT V559I [plasma membrane] (R-HSA-9669557) KIT K550_K558del [plasma membrane] (R-HSA-9669461) KIT V559G [plasma membrane] (R-HSA-9669554) KIT V559D [plasma membrane] (R-HSA-9669551) KIT W557_K558del [plasma membrane] (R-HSA-9670343) KIT Y823D [plasma membrane] (R-HSA-9669587) KIT D816V [plasma membrane] (R-HSA-9669452) KIT N822Y [plasma membrane] (R-HSA-9669454) KIT T670I [plasma membrane] (R-HSA-9669545) KIT D820E [plasma membrane] (R-HSA-9669449) KIT V654A [plasma membrane] (R-HSA-9669572) KIT D816H [plasma membrane] (R-HSA-9669445) KIT K642E [plasma membrane] (R-HSA-9669443) KIT V560D [plasma membrane] (R-HSA-9669564) KIT N822H [plasma membrane] (R-HSA-9669437) KIT A502_Y503dup [plasma membrane] (R-HSA-9680030) KIT N822K [plasma membrane] (R-HSA-9669464) KIT D816Y [plasma membrane] (R-HSA-9669435) KIT D820A [plasma membrane] (R-HSA-9669460) KIT N822T [plasma membrane] (R-HSA-9669463) KIT D816F [plasma membrane] (R-HSA-9669457) KIT K642Q [plasma membrane] (R-HSA-9669468) KIT D816E [plasma membrane] (R-HSA-9669436) KIT N822I [plasma membrane] (R-HSA-9669453) KIT V560E [plasma membrane] (R-HSA-9669566) KIT N822S [plasma membrane] (R-HSA-9669466) KIT D816N [plasma membrane] (R-HSA-9669451) KIT D816A [plasma membrane] (R-HSA-9669428) KIT V560G [plasma membrane] (R-HSA-9669569) p-8Y-KIT [plasma membrane] (R-HSA-1472116) p-S741,S746-KIT [plasma membrane] (R-HSA-1433492) KIT [plasma membrane] (R-HSA-197662) p-7Y-KIT [plasma membrane] (R-HSA-205207)	0.702	31
UniProt:P21802-1 FGFR2	20	FGFR2c P253R [plasma membrane] (R-HSA-1637916) FGFR2c S252W [plasma membrane] (R-HSA-2011852) FGFR2c A315S [plasma membrane] (R-HSA-2071931) FGFR2c A314S [plasma membrane] (R-HSA-2071928) FGFR2c A314D [plasma membrane] (R-HSA-1637888) FGFR2c A315T [plasma membrane] (R-HSA-1637889) FGFR2c W290G [plasma membrane] (R-HSA-2029883) FGFR2c Y375C [plasma membrane] (R-HSA-2029881) FGFR2c S372C [plasma membrane] (R-HSA-2029886) p-8Y-FGFR2c S252W [plasma membrane] (R-HSA-2011879) p-8Y-FGFR2c P253R [plasma membrane] (R-HSA-2011880) p-8Y-FGFR2c A315S mutant [plasma membrane] (R-HSA-2071942) p-8Y-FGFR2c A314S [plasma membrane] (R-HSA-2071944) p-8Y-FGFR2c A314D [plasma membrane] (R-HSA-2071946) p-8Y-FGFR2c A315T [plasma membrane] (R-HSA-2071940) p-8Y-FGFR2c W290G [plasma membrane] (R-HSA-2029862) p-8Y-FGFR2c S372C [plasma membrane] (R-HSA-2029865) p-8Y-FGFR2c Y375C [plasma membrane] (R-HSA-2029861) FGFR2c long [plasma membrane] (R-HSA-189920) p-8Y-FGFR2c long [plasma membrane] (R-HSA-190416)	0.698	9
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.692	3
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.667	3
UniProt:Q92918 M4K1			0.664	6
UniProt:P09327 VILI			0.656	5
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.639	7
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.602	3
UniProt:O43150 ASAP2			0.602	3
UniProt:Q9UPX8 SHANK2	1	SHANK2 [cytosol] (R-HSA-6794265)	0.602	4
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.602	4
UniProt:Q8TB24 RIN3	1	RIN3 [cytosol] (R-HSA-8875292)	0.602	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.602	4
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.602	9
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.564	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:P07949 RET	2	p-5Y-RET [plasma membrane] (R-HSA-8854162) RET [plasma membrane] (R-HSA-8853797)	0.564	2
UniProt:Q9H1R2 DUS15			0.544	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.544	2
UniProt:Q15036 SNX17			0.544	2
UniProt:P31994 FCGR2B	1	FCGR2B [plasma membrane] (R-HSA-197854)	0.544	2
UniProt:P78314 3BP2			0.527	2
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.525	2
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.525	2
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.525	2
UniProt:P16234 PDGFRA	47	PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA D843_846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974) PDGFRA D843_844del [plasma membrane] (R-HSA-9671559) PDGFRA D846V [plasma membrane] (R-HSA-9674306) PDGFRA D842L [plasma membrane] (R-HSA-9674303) PDGFRA V561D [plasma membrane] (R-HSA-9671557) PDGFRA V561A [plasma membrane] (R-HSA-9671968) PDGFRA V536E [plasma membrane] (R-HSA-9671964) PDGFRA V536M [plasma membrane] (R-HSA-9676950) p-11Y PDGFRA D842V [plasma membrane] (R-HSA-9671979) p-11Y PDGFRA D846Y [plasma membrane] (R-HSA-9672009) p-11Y PDGFRA D842del [plasma membrane] (R-HSA-9671998) p-11Y PDGFRA D843_844del [plasma membrane] (R-HSA-9672001) p-11Y PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671991) p-11Y PDGFRA D843_846del [plasma membrane] (R-HSA-9672007) p-11Y PDGFRA D842Y [plasma membrane] (R-HSA-9671982) p-11Y PDGFRA D842_H845del [plasma membrane] (R-HSA-9671989) p-11Y PDGFRA D842_D846del [plasma membrane] (R-HSA-9671986) p-10Y PDGFRA Y849C [plasma membrane] (R-HSA-9671977) p-11Y PDGFRA D843_845del [plasma membrane] (R-HSA-9672003) p-11Y PDGFRA N848K [plasma membrane] (R-HSA-9672015) p-11Y PDGFRA D842L dimer [plasma membrane] (R-HSA-9674313) p-11Y PDGFRA D846V [plasma membrane] (R-HSA-9674316) p-11Y PDGFRA V536E [plasma membrane] (R-HSA-9672018) p-11Y PDGFRA V536M [plasma membrane] (R-HSA-9676956) p-11Y PDGFRA V561D [plasma membrane] (R-HSA-9672025) p-11Y PDGFRA V561A [plasma membrane] (R-HSA-9672021) PDGFRA [plasma membrane] (R-HSA-186794) p-11Y-PDGFRA [plasma membrane] (R-HSA-186806)	0.508	2
UniProt:Q8N1K5-1 THEMIS			0.499	3
UniProt:P20273 CD22	3	CD22 [plasma membrane] (R-HSA-197703) NAc-CD22 [plasma membrane] (R-HSA-5690736) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.499	2
UniProt:Q8N1K5 THMS1			0.462	4
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	3
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.462	2
UniProt:P04629 NTRK1	4	NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.462	2
UniProt:P43405 SYK	6	SYK [plasma membrane] (R-HSA-139844) p-Y-SYK [plasma membrane] (R-HSA-429432) p-6Y-SYK [cytosol] (R-HSA-983586) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268) p-6Y-SYK [cytosol] (R-HSA-1861712)	0.462	4