Reactome | p-Y771,Y783-PLCG1 [plasma membrane]

p-Y771,Y783-PLCG1 [plasma membrane]

Stable Identifier

R-HSA-1169084

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y771,Y783-PLCG1(1-1290), Phospholipase C gamma 1 phosphorylated at Tyr-771 and Tyr-783, Phospho-PLC gamma 1

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Literature References

PubMed ID	Title	Journal	Year
15161916	Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation Kim, YJ, Rhee, SG, Sekiya, F, Poulin, B	J Biol Chem	2004

External Reference Information

External Reference

UniProt:P19174 PLCG1

Gene Names

PLCG1, PLC1

Chain

initiator methionine:1, chain:2-1290

Reference Genes

BioGPS Gene:5335 PLCG1

COSMIC (genes):PLCG1 PLCG1

CTD Gene:5335 PLCG1

dbSNP Gene:5335 PLCG1

ENSEMBL:ENSG00000124181 PLCG1

HGNC:9065 PLCG1

KEGG Gene (Homo sapiens):5335 PLCG1

Monarch:5335 PLCG1

NCBI Gene:5335 PLCG1

OMIM:172420 PLCG1

UCSC:P19174 PLCG1

Reference Transcript

Other Identifiers

0006100026

1082_at

11723761_a_at

11723762_at

16913761

16913806

202789_PM_at

202789_at

216551_PM_x_at

216551_x_at

240805_PM_at

240805_at

34351_at

3885545

3885546

3885547

3885548

3885559

3885560

3885561

3885563

3885564

3885566

3885568

3885569

3885570

3885571

3885572

3885573

3885574

3885576

3885577

3885578

3885581

3885582

3885583

3885585

3885587

3885588

3885589

3885590

3885591

3885595

3885596

3885597

3885600

3885602

3885603

3885604

3885606

3885607

3885608

3885609

3885610

3885611

3885612

3885613

3885614

3885615

3885616

3885617

3885618

3885619

3885620

3885621

3885623

3885624

5335

8062623

81996_at

A_14_P119146

A_14_P134037

GE537103

GE81175

GE88032

GO:0001726

GO:0002376

GO:0002862

GO:0003674

GO:0004435

GO:0004629

GO:0005168

GO:0005509

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006629

GO:0006810

GO:0006950

GO:0007165

GO:0007173

GO:0008081

GO:0008150

GO:0008180

GO:0008219

GO:0008283

GO:0009056

GO:0009395

GO:0010634

GO:0016042

GO:0016477

GO:0016787

GO:0019722

GO:0019899

GO:0019901

GO:0030027

GO:0032587

GO:0032991

GO:0035556

GO:0038095

GO:0040011

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043536

GO:0045766

GO:0046488

GO:0046872

GO:0048646

GO:0048856

GO:0048870

GO:0050429

GO:0050852

GO:0051281

GO:0055085

GO:0071364

GO:1905564

GO:2000353

HMNXSV003018394

HMNXSV003030519

HMNXSV003044393

Hs.161402.0.A1_3p_at

Hs.268177.0.S2_3p_at

Hs.268177.1.S1_3p_a_at

ILMN_1740160

ILMN_2382906

M34667_at

PH_hs_0027331

TC20000303.hg

Participates

as a member of

p-PLC gamma1,2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-4Y-PLCG1 [plasma membrane]

PLCG1 [plasma membrane]

PLCG1 [cytosol]

p-Y771,Y783,Y1254-PLCG1 [cytosol]

p-Y-PLCG1 [cytosol]

Inferred To

phospho-plcg1 [plasma membrane] (Xenopus tropicalis)

phospho-PLCG1 [plasma membrane] (Bos taurus)

phospho-PLCG1 [plasma membrane] (Canis familiaris)

phospho-PLCG1 [plasma membrane] (Gallus gallus)

phospho-PLCG1 [plasma membrane] (Sus scrofa)

phospho-Plcg1 [plasma membrane] (Mus musculus)

phospho-Plcg1 [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 771

Coordinate

771

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 783

Coordinate

783

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002651.2, NP_877963.1

Guide to Pharmacology - Targets

1407

OpenTargets

ENSG00000124181

ZINC - Substances

PLCG1_HUMAN

ZINC target

P19174

PRO

P19174

PDB

4FBN, 1HSQ, 7NXE, 4EY0, 2HSP

HPA

ENSG00000124181-PLCG1

GeneCards

P19174

Ensembl

ENST00000244007, ENSG00000124181, ENSP00000244007, ENSP00000362368, ENST00000373271

Pharos - Targets

P19174

ZINC - Predictions - Purchasable

PLCG1_HUMAN

HMDB Protein

HMDBP00244

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	8	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.862	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.85	6
UniProt:O43561 LAT	3	p-5Y-LAT [plasma membrane] (R-HSA-202364) LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.81	7
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.806	6
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.799	9
UniProt:P21802-1 FGFR2	20	FGFR2c S252W [plasma membrane] (R-HSA-2011852) FGFR2c P253R [plasma membrane] (R-HSA-1637916) FGFR2c A315S [plasma membrane] (R-HSA-2071931) FGFR2c A314S [plasma membrane] (R-HSA-2071928) FGFR2c A314D [plasma membrane] (R-HSA-1637888) FGFR2c A315T [plasma membrane] (R-HSA-1637889) FGFR2c W290G [plasma membrane] (R-HSA-2029883) FGFR2c Y375C [plasma membrane] (R-HSA-2029881) FGFR2c S372C [plasma membrane] (R-HSA-2029886) p-8Y-FGFR2c S252W [plasma membrane] (R-HSA-2011879) p-8Y-FGFR2c P253R [plasma membrane] (R-HSA-2011880) p-8Y-FGFR2c A315S mutant [plasma membrane] (R-HSA-2071942) p-8Y-FGFR2c A314S [plasma membrane] (R-HSA-2071944) p-8Y-FGFR2c A314D [plasma membrane] (R-HSA-2071946) p-8Y-FGFR2c A315T [plasma membrane] (R-HSA-2071940) p-8Y-FGFR2c W290G [plasma membrane] (R-HSA-2029862) p-8Y-FGFR2c S372C [plasma membrane] (R-HSA-2029865) p-8Y-FGFR2c Y375C [plasma membrane] (R-HSA-2029861) FGFR2c long [plasma membrane] (R-HSA-189920) p-8Y-FGFR2c long [plasma membrane] (R-HSA-190416)	0.698	9
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.692	3
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.675	31
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.667	3
UniProt:Q92918 M4K1			0.664	6
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.639	7
UniProt:P09327 VILI			0.628	5
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.602	3
UniProt:O43150 ASAP2			0.602	3
UniProt:Q9UPX8 SHANK2	1	SHANK2 [cytosol] (R-HSA-6794265)	0.602	4
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.602	4
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.602	4
UniProt:Q8TB24 RIN3	1	RIN3 [cytosol] (R-HSA-8875292)	0.602	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.602	9
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.564	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:Q9H1R2 DUS15			0.544	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.544	2
UniProt:Q15036 SNX17			0.544	2
UniProt:P31994 FCGR2B	1	FCGR2B [plasma membrane] (R-HSA-197854)	0.544	2
UniProt:P78314 3BP2			0.527	2
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.525	2
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.525	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.525	2
UniProt:Q8N1K5-1 THEMIS			0.499	3
UniProt:P20273 CD22	3	NAc-CD22 [plasma membrane] (R-HSA-5690736) CD22 [plasma membrane] (R-HSA-197703) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.499	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.483	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	3
UniProt:Q8N1K5 THMS1			0.462	4
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.462	2
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.462	2
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.462	4

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