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p-Y771,Y783-PLCG1 [plasma membrane]
Stable Identifier
R-HSA-1169084
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Y771,Y783-PLCG1(1-1290), Phospholipase C gamma 1 phosphorylated at Tyr-771 and Tyr-783, Phospho-PLC gamma 1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
p-PLC gamma1,2 [plasma membrane] (Homo sapiens)
p-Y771,Y783-PLCG1 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15161916
Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
Sekiya, F
,
Poulin, B
,
Kim, YJ
,
Rhee, SG
J Biol Chem
2004
External Reference Information
External Reference
UniProt:P19174 PLCG1
Gene Names
PLCG1, PLC1
Chain
initiator methionine:1, chain:2-1290
Reference Genes
BioGPS Gene:5335 PLCG1
COSMIC (genes):PLCG1 PLCG1
CTD Gene:5335 PLCG1
dbSNP Gene:5335 PLCG1
ENSEMBL:ENSG00000124181 PLCG1
HGNC:9065 PLCG1
KEGG Gene (Homo sapiens):5335 PLCG1
Monarch:5335 PLCG1
NCBI Gene:5335 PLCG1
OMIM:172420 PLCG1
UCSC:P19174 PLCG1
Reference Transcript
RefSeq:NM_002660.2 PLCG1
RefSeq:NM_182811.1 PLCG1
Other Identifiers
0006100026
00562+3.1.4.11
04070+3.1.4.11
1082_at
11723761_a_at
11723762_at
16913761
16913806
1HSQ
202789_at
216551_x_at
240805_at
2HSP
34351_at
36681
36682
3885545
3885546
3885547
3885548
3885559
3885560
3885561
3885563
3885564
3885566
3885568
3885569
3885570
3885571
3885572
3885573
3885574
3885576
3885577
3885578
3885581
3885582
3885583
3885585
3885587
3885588
3885589
3885590
3885591
3885595
3885596
3885597
3885600
3885602
3885603
3885604
3885606
3885607
3885608
3885609
3885610
3885611
3885612
3885613
3885614
3885615
3885616
3885617
3885618
3885619
3885620
3885621
3885623
3885624
4277
4EY0
4FBN
5335
8062623
81996_at
A_14_P119146
A_14_P134037
AAA36452
AAI36467
AAI44137
ABB84466
AL022394
BC136466
BC144136
CAB004277
CCDS13313
CCDS13314
CH471077
DQ297143
EAW75991
EAW75992
ENSG00000124181
ENSP00000244007
ENSP00000362368
ENST00000244007
ENST00000244007.7
ENST00000373271
ENST00000373271.5
EntrezGene:5335
EntrezGene:PLCG1
GE537103
GE81175
GE88032
GO:0000902
GO:0001701
GO:0001726
GO:0002376
GO:0003674
GO:0004435
GO:0004629
GO:0005168
GO:0005509
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006629
GO:0006810
GO:0007165
GO:0007173
GO:0007202
GO:0007267
GO:0007411
GO:0008081
GO:0008150
GO:0008180
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0009395
GO:0009790
GO:0010634
GO:0010863
GO:0016032
GO:0016042
GO:0016192
GO:0016477
GO:0016787
GO:0019722
GO:0019899
GO:0019901
GO:0030027
GO:0030154
GO:0030971
GO:0032959
GO:0032991
GO:0035254
GO:0035556
GO:0038095
GO:0038096
GO:0040011
GO:0042592
GO:0042995
GO:0043167
GO:0043226
GO:0043536
GO:0043647
GO:0044281
GO:0044403
GO:0045766
GO:0046872
GO:0048015
GO:0048646
GO:0048856
GO:0048870
GO:0050804
GO:0050852
GO:0050900
GO:0051209
GO:0051281
GO:0055085
GO:0071364
GO:0098685
GO:0098978
GO:1905564
GO:2000353
HGNC:9065
HPA036681
HPA036682
Hs.161402.0.A1_3p_at
Hs.268177.0.S2_3p_at
Hs.268177.1.S1_3p_a_at
ILMN_1740160
ILMN_2382906
IPR000008
IPR000909
IPR000980
IPR001192
IPR001452
IPR001711
IPR001849
IPR002048
IPR011992
IPR011993
IPR016279
IPR017946
IPR018247
IPR028380
IPR035023
IPR035024
IPR035724
IPR035892
IPR036028
IPR036860
M0QX77
M34667
M34667_at
MIM:172420
NM_002660
NM_182811
NP_002651
NP_877963
PF00017
PF00018
PF00168
PF00387
PF00388
PH_hs_0027331
PLCG1
PLCG1-201
PLCG1-202
PR00390
PR00401
SM00148
SM00149
SM00233
SM00239
SM00252
SM00326
TC20000303.hg
UPI0000131AA5
UPI00001B94DD
V9GY63
V9GY71
XM_005260438
XM_011528865
XM_011528867
XP_005260495
XP_011527167
XP_011527169
XR_001754293
XR_001754294
XR_001754295
XR_001754296
Participant Of
hasMember
p-PLC gamma1,2 [plasma membrane]
Other forms of this molecule
p-4Y-PLCG1 [plasma membrane]
p-Y771,Y783,Y1254-PLCG1 [cytosol]
PLCG1 [cytosol]
PLCG1 [plasma membrane]
p-Y-PLCG1 [cytosol]
Inferred To
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Bos taurus)
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Canis familiaris)
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Danio rerio)
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Mus musculus)
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Rattus norvegicus)
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Sus scrofa)
phospho-p-Y771,Y783-PLCG1 [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 771
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 783
Coordinate
783
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002651.2
,
NP_877963.1
OpenTargets
ENSG00000124181
ZINC - Substances
PLCG1_HUMAN
GeneCards
P19174
ZINC target
P19174
PRO
P19174
ZINC - Predictions - Purchasable
PLCG1_HUMAN
HMDB Protein
HMDBP00244
PDB
4FBN
,
1HSQ
,
4EY0
,
2HSP
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
8
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
0.872
9
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.85
6
UniProt:P09619 PDGFRB
3
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.822
6
UniProt:O43561 LAT
3
LAT [plasma membrane]
(R-HSA-202322)
p-Y200,Y220-LAT [plasma membrane]
(R-HSA-434829)
p-5Y-LAT [plasma membrane]
(R-HSA-202364)
0.81
7
UniProt:P06213 INSR
6
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.799
9
UniProt:P10721 KIT
4
p-S741,S746-KIT [plasma membrane]
(R-HSA-1433492)
p-8Y-KIT [plasma membrane]
(R-HSA-1472116)
KIT [plasma membrane]
(R-HSA-197662)
p-7Y-KIT [plasma membrane]
(R-HSA-205207)
0.702
31
UniProt:P21802-1 FGFR2
20
FGFR2c P253R [plasma membrane]
(R-HSA-1637916)
FGFR2c S252W [plasma membrane]
(R-HSA-2011852)
FGFR2c A315S [plasma membrane]
(R-HSA-2071931)
FGFR2c A314S [plasma membrane]
(R-HSA-2071928)
FGFR2c A314D [plasma membrane]
(R-HSA-1637888)
FGFR2c A315T [plasma membrane]
(R-HSA-1637889)
FGFR2c W290G [plasma membrane]
(R-HSA-2029883)
FGFR2c Y375C [plasma membrane]
(R-HSA-2029881)
FGFR2c S372C [plasma membrane]
(R-HSA-2029886)
p-8Y-FGFR2c S252W [plasma membrane]
(R-HSA-2011879)
p-8Y-FGFR2c P253R [plasma membrane]
(R-HSA-2011880)
p-8Y-FGFR2c A315S mutant [plasma membrane]
(R-HSA-2071942)
p-8Y-FGFR2c A314S [plasma membrane]
(R-HSA-2071944)
p-8Y-FGFR2c A314D [plasma membrane]
(R-HSA-2071946)
p-8Y-FGFR2c A315T [plasma membrane]
(R-HSA-2071940)
p-8Y-FGFR2c W290G [plasma membrane]
(R-HSA-2029862)
p-8Y-FGFR2c S372C [plasma membrane]
(R-HSA-2029865)
p-8Y-FGFR2c Y375C [plasma membrane]
(R-HSA-2029861)
FGFR2c long [plasma membrane]
(R-HSA-189920)
p-8Y-FGFR2c long [plasma membrane]
(R-HSA-190416)
0.698
9
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.692
3
UniProt:Q07889 SOS1
3
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [cytosol]
(R-HSA-64847)
0.667
3
UniProt:Q92918 M4K1
0.664
6
UniProt:P09327 VILI
0.656
5
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.639
7
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.602
9
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.602
3
UniProt:O43150 ASAP2
0.602
3
UniProt:Q9UPX8 SHANK2
1
SHANK2 [cytosol]
(R-HSA-6794265)
0.602
4
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.602
4
UniProt:Q07890 SOS2
1
SOS2 [cytosol]
(R-HSA-167221)
0.602
4
UniProt:Q8TB24 RIN3
1
RIN3 [cytosol]
(R-HSA-8875292)
0.602
3
UniProt:P07949 RET
2
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
RET [plasma membrane]
(R-HSA-8853797)
0.564
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.564
2
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.564
3
UniProt:Q9H1R2 DUS15
0.544
2
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.544
2
UniProt:Q15036 SNX17
0.544
2
UniProt:P31994 FCGR2B
1
FCGR2B [plasma membrane]
(R-HSA-197854)
0.544
2
UniProt:P78314 3BP2
0.527
2
UniProt:Q03135 CAV1
5
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [Golgi membrane]
(R-HSA-204504)
0.525
2
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.525
2
UniProt:Q9BZW8 CD244
1
CD244 [plasma membrane]
(R-HSA-197846)
0.525
2
UniProt:P16234 PDGFRA
2
PDGFRA [plasma membrane]
(R-HSA-186794)
p-11Y-PDGFRA [plasma membrane]
(R-HSA-186806)
0.508
2
UniProt:Q8N1K5-1 THEMIS
0.499
3
UniProt:P20273 CD22
3
CD22 [plasma membrane]
(R-HSA-197703)
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.499
2
UniProt:P30530 AXL
2
p-Y772,Y814-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.462
2
UniProt:P43405 SYK
6
SYK [plasma membrane]
(R-HSA-139844)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
p-6Y-SYK [cytosol]
(R-HSA-983586)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.462
4
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
3
UniProt:Q8N1K5 THMS1
0.462
4
UniProt:P04629 NTRK1
4
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.462
2
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