Activation of RAS in B cells

Stable Identifier
R-HSA-1169092
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Pathway
Species
Homo sapiens
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RasGRP1 and RasGRP3 bind diacylglycerol at the plasma membrane (Lorenzo et al. 2001) and are phosphorylated by protein kinase C (Teixeira et al. 2003, Zheng et al. 2005). Phosphorylated RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) then catalyze the exchange of GDP for GTP bound by RAS, thereby activating RAS.

Literature References
PubMed ID Title Journal Year
10934204 Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

Rebhun, JF, Castro, AF, Quilliam, LA

J Biol Chem 2000
17283063 Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes

Roose, JP, Mollenauer, M, Ho, M, Kurosaki, T, Weiss, A

Mol Cell Biol 2007
15657177 Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells

Zheng, Y, Liu, H, Coughlin, J, Zheng, J, Li, L, Stone, JC

Blood 2005
12730099 Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

Teixeira, C, Stang, SL, Zheng, Y, Beswick, NS, Stone, JC

Blood 2003
10777492 Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3

Ohba, Y, Mochizuki, N, Yamashita, S, Chan, AM, Schrader, JW, Hattori, S, Nagashima, K, Matsuda, M

J Biol Chem 2000
10835426 CalDAG-GEFIII activation of Ras, R-ras, and Rap1

Yamashita, S, Mochizuki, N, Ohba, Y, Tobiume, M, Okada, Y, Sawa, H, Nagashima, K, Matsuda, M

J Biol Chem 2000
11221888 Phorbol esters modulate the Ras exchange factor RasGRP3

Lorenzo, PS, Kung, JW, Bottorff, DA, Garfield, SH, Stone, JC, Blumberg, PM

Cancer Res 2001
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