Reactome: A Curated Pathway Database

SHP1 (PTPN6) dephosphorylates JAK2

Stable Identifier
R-HSA-1169188
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SHP1 (PTPN6) dephosphorylates GH-activated JAK2, limiting the duration of signaling (Hackett et al. 1999).

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] protein tyrosine phosphatase activity (0004725)
Inferred From