PTP1B dephosphorylates JAK2

Stable Identifier
R-HSA-1169210
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PTP1B dephosphorylates JAK2 (Gu et al. 2003), limiting ligand-dependent signaling.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane]
Physical Entity
Activity
Inferred From