Reactome | GHR(19-638) [endosome lumen]

GHR(19-638) [endosome lumen]

Stable Identifier

R-HSA-1169263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome lumen

Synonyms

Growth Hormone Receptor, GHR, GHR_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10912 GHR

Gene Names

GHR

Chain

signal peptide:1-18, chain:19-638, chain:19-256

Reference Genes

BioGPS Gene:2690 GHR

COSMIC (genes):GHR GHR

CTD Gene:2690 GHR

dbSNP Gene:2690 GHR

ENSEMBL:ENSG00000112964 GHR

HGNC:4263 GHR

KEGG Gene (Homo sapiens):2690 GHR

Monarch:2690 GHR

NCBI Gene:2690 GHR

OMIM:600946 GHR

UCSC:P10912 GHR

Reference Transcript

Other Identifiers

0003360364

11728055_at

11752376_a_at

1215_at

160030_at

16984365

205498_at

2690

2807961

2807962

2807963

2807978

2807984

2807988

2808001

2808007

2808008

2808009

2808010

2808013

2808014

2808015

2808016

2808018

2808019

2808020

2808021

2808022

8105121

A_14_P116270

A_23_P156087

A_24_P72064

A_33_P3260733

GE59684

GO:0000187

GO:0003674

GO:0004896

GO:0004903

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005887

GO:0006464

GO:0006790

GO:0006810

GO:0006897

GO:0007165

GO:0007259

GO:0008150

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0016192

GO:0017046

GO:0019221

GO:0019530

GO:0019838

GO:0019899

GO:0019901

GO:0019955

GO:0032870

GO:0032991

GO:0036464

GO:0040007

GO:0040014

GO:0040018

GO:0042445

GO:0042531

GO:0042802

GO:0042803

GO:0042976

GO:0043226

GO:0043235

GO:0044281

GO:0046427

GO:0048009

GO:0050731

GO:0060396

GO:0060397

GO:0070064

GO:0070195

ILMN_1775814

ILMN_1833977

ILMN_1837244

ILMN_1845433

PH_hs_0007066

TC05002346.hg

TC05002347.hg

X06562_at

g4503992_3p_at

Participant Of

output

GHR internalization

Other forms of this molecule

p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]

GHR(257-638) [plasma membrane]

p-5Y-GHR(19-638) [plasma membrane]

GHR(19-256) [extracellular region]

GHR(19-638) [plasma membrane]

GHR activated [plasma membrane]

Cross References

RefSeq

NP_001229391.1, NP_000154.1, NP_001229329.1, NP_001229328.1, NP_001229330.1, NP_001229334.1, NP_001229389.1, NP_001229333.1, NP_001229331.1, NP_001229335.1, NP_001229332.1

OpenTargets

ENSG00000112964

HPA

ENSG00000112964-GHR

GeneCards

P10912

Ensembl

ENSP00000478291, ENSP00000442206, ENST00000618088, ENSP00000350335, ENST00000537449, ENSP00000482373, ENST00000615111, ENSP00000479846, ENST00000230882, ENSP00000230882, ENST00000612626, ENST00000612382, ENSP00000478332, ENST00000357703, ENSG00000112964

PRO

P10912

Orphanet

16122

PDB

1A22, 1HWH, 5OHD, 1AXI, 1KF9, 2AEW, 3HHR, 5OEK, 1HWG

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01241 GH1	2	GH1 [extracellular region] (R-HSA-422070) GH1 [endosome lumen] (R-HSA-8942972)	0.73	4
UniProt:P23467 PTPRB	3	PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032) PTPRB [specific granule membrane] (R-HSA-6799638)	0.683	3
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.645	5
UniProt:Q9HD43 PTPRH			0.645	4
UniProt:P26045 PTPN3	3	p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317) PTPN3 [cytosol] (R-HSA-8867650)	0.645	4
UniProt:P17706 PTPN2	2	PTPN2 [cytosol] (R-HSA-997292) PTPN2 [nucleoplasm] (R-HSA-9008891)	0.645	8
UniProt:P10912 GHR	7	GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.591	4
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.589	3
UniProt:Q16829 DUSP7	2	DUSP7 [cytosol] (R-HSA-5675346) DUSP7 [nucleoplasm] (R-HSA-203791)	0.558	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.558	2
UniProt:Q9JLI4 NCOA6			0.508	2

Cite Us!