The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.
Shi, HX, Yang, K, Liu, X, Liu, XY, Wei, B, Shan, YF, Zhu, LH, Wang, C
Lu, G, Reinert, JT, Pitha-Rowe, I, Okumura, A, Kellum, M, Knobeloch, KP, Hassel, B, Pitha-Rowe, PM
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