ISGylation of IRF3

Stable Identifier
R-HSA-1169394
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ISGylation of IRF3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.

Literature References
PubMed ID Title Journal Year
20308324 Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification

Shi, HX, Yang, K, Liu, X, Liu, XY, Wei, B, Shan, YF, Zhu, LH, Wang, C

Mol Cell Biol 2010
16914094 ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation

Lu, G, Reinert, JT, Pitha-Rowe, I, Okumura, A, Kellum, M, Knobeloch, KP, Hassel, B, Pitha-Rowe, PM

Cell Mol Biol (Noisy-le-grand) 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
Physical Entity
ISG15:UBCH8:ISG15 E3 ligase [cytosol]
Activity
ubiquitin-protein transferase activity (0004842)
Orthologous Events
ISGylation of IRF3 (Bos taurus)
ISGylation of IRF3 (Canis familiaris)
ISGylation of IRF3 (Danio rerio)
ISGylation of IRF3 (Mus musculus)
ISGylation of IRF3 (Rattus norvegicus)
ISGylation of IRF3 (Xenopus tropicalis)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-01-18)
Cite Us!