Activation of ISG15 by UBA7 E1 ligase

Stable Identifier
R-HSA-1169397
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L activates ISG15 in an ATP-dependent process that links UBE1L to ISG15 via a thioester bond. Arginine 153 (R153) in human ISG15 is identified as the key residue for ISG15 and UBE1L's interaction.

Literature References
PubMed ID Title Journal Year
18583345 The basis for selective E1-E2 interactions in the ISG15 conjugation system

Durfee, LA, Kelley, ML, Huibregtse, JM

J Biol Chem 2008
19073728 ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus

Giannakopoulos, NV, Arutyunova, E, Lai, C, Lenschow, DJ, Haas, AL, Virgin, HW

J Virol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of UBA7 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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