ISGylation of E2 conjugating enzymes

Stable Identifier
R-HSA-1169402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005).

Literature References
PubMed ID Title Journal Year
16428300 Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme

Takeuchi, T, Iwahara, S, Saeki, Y, Sasajima, H, Yokosawa, H

J Biochem 2005
16112642 ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity

Takeuchi, T, Yokosawa, H

Biochem Biophys Res Commun 2005
16122702 ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin

Zou, W, Papov, V, Malakhova, O, Kim, KI, Dao, C, Li, J, Zhang, DE

Biochem Biophys Res Commun 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
Physical Entity
Activity
Orthologous Events
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Created
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