Transfer of ISG15 from E1 to E2 (UBCH8)

Stable Identifier
R-HSA-1169404
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated ISG15 linked to UBE1L is transferred to the E2 conjugating enzyme UBCH8.

Literature References
PubMed ID Title Journal Year
15131269 The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

Zhao, C, Beaudenon, SL, Kelley, ML, Waddell, MB, Yuan, W, Schulman, BA, Huibregtse, JM, Krug, RM

Proc Natl Acad Sci U S A 2004
11157743 Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

Yuan, W, Krug, RM

EMBO J 2001
15485925 Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation

Kim, KI, Giannakopoulos, NV, Virgin, HW, Zhang, DE

Mol Cell Biol 2004
18583345 The basis for selective E1-E2 interactions in the ISG15 conjugation system

Durfee, LA, Kelley, ML, Huibregtse, JM

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin binding activity of UBE2L6 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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