ISGylation of protein phosphatase 1 beta (PP2CB)

Stable Identifier
R-HSA-1169405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Protein phosphatase 1 beta (PPM1B/PP2CB) is a target for ISG15. PP2CB dephosphorylates TAK1 and suppresses TAK1/TAB1-mediated IkB alpha degradation and thereby controls the NF-kB signaling pathway, which plays a critical role in innate and adaptive immunity and cancer. ISGylation of PP2CB may block the suppressive function of the phosphatase against TAK1/TAB1 mediated NF-kB activation.

Literature References
PubMed ID Title Journal Year
16872604 Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation

Takeuchi, T, Kobayashi, T, Tamura, S, Yokosawa, H

FEBS Lett 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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