Antimicrobial mechanism of IFN-stimulated genes

Stable Identifier
R-HSA-1169410
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
Synonyms
Antiviral mechanism by IFN-stimulated genes
ReviewStatus
5/5
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Antimicrobial mechanism of IFN-stimulated genes
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Interferons activate JAK–STAT signaling, which leads to the transcriptional induction of hundreds of IFN-stimulated genes (ISGs). The ISG-encoded proteins include direct effectors which inhibit viral infection through diverse mechanisms as well as factors that promote adaptive immune responses. The ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
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Orthologous Events
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Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Matthews, L  (2025-08-05)
Created
Garapati, P V  (2011-01-18)
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