Reactome | KPNA4 [nucleoplasm]

KPNA4 [nucleoplasm]

Stable Identifier

R-HSA-1176058

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Importin subunit alpha-4, IMA4, IMA4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00629 KPNA4

Gene Names

KPNA4, QIP1

Chain

initiator methionine:, chain:2-521

Reference Genes

BioGPS Gene:3840 KPNA4

COSMIC (genes):KPNA4 KPNA4

CTD Gene:3840 KPNA4

dbSNP Gene:3840 KPNA4

ENSEMBL:ENSG00000186432 KPNA4

HGNC:6397 KPNA4

KEGG:hsa:3840 KPNA4

Monarch:3840 KPNA4

NCBI Gene:3840 KPNA4

OMIM:602970 KPNA4

UCSC:O00629 KPNA4

Reference Transcript

RefSeq:NM_002268.4 KPNA4

Other Identifiers

11732194_s_at

11732195_at

11732196_x_at

16961016

209653_PM_at

209653_at

213567_PM_at

213567_at

225267_PM_at

225267_at

225268_PM_at

225268_at

2703225

2703226

2703227

2703228

2703229

2703230

2703231

2703232

2703233

2703234

2703235

2703236

2703237

2703239

2703240

2703241

2703242

2703243

2703246

2703249

2703250

2703252

2703253

2703254

2703255

2703256

2703258

2703259

2703260

2703261

2703268

2703269

2703270

2703271

2703273

2703274

2703275

2703276

2703278

2915790

2915792

2915795

38154_at

3840

48814_at

8091764

A_19_P00802654

A_19_P00813347

A_23_P218835

A_24_P11791

A_24_P362769

A_32_P3127

GE54318

GE757092

GE81136

GE83513

GO:0005515

GO:0005634

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006606

GO:0006607

GO:0006886

GO:0006913

GO:0008139

GO:0010467

GO:0014046

GO:0015031

GO:0031965

GO:0042564

GO:0043226

GO:0061608

GO:0140104

HMNXSV003029317

Hs.153106.0.S1_3p_at

Hs.288193.0.S1_3p_at

Hs.288193.0.S2_3p_at

Hs.288193.0.S2_3p_x_at

ILMN_1664756

PH_hs_0032511

TC03001956.hg

TC03003184.hg

Y12393_s_at

g1928974_3p_at

Participates

as a member of

Importin alpha [nucleoplasm] (Homo sapiens)

Other forms of this molecule

KPNA4 [cytosol]

Cross References

RefSeq

NP_002259.1

OpenTargets

ENSG00000186432

ENSEMBL

ENSP00000334373, ENST00000334256

HPA

ENSG00000186432-KPNA4

PRO

O00629

Pharos - Targets

O00629

GlyGen

O00629

HMDB Protein

HMDBP08459

PDB

6WX8, 5XZX, 7LFC, 5TBK, 6BVV, 8FZM, 4UAE, 7RG5, 7LF4, 6BVZ, 8FUB, 7JJL, 6BW9, 8HKW, 7RFY, 6BWB, 6BWA

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.834	8
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.8	6
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.775	20
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.737	32
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.666	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.643	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	3
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.638	3
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.581	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.571	2
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.527	3
UniProt:Q9BQB4 SOST	1	SOST [extracellular region] (R-HSA-3769322)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.527	2
UniProt:P18754 RCC1	2	RCC1 [chromosome] (R-HSA-9668547) RCC1 [nucleoplasm] (R-HSA-180690)	0.527	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	2
UniProt:Q8K4J6	3	Mrtfa [nucleoplasm] (R-MMU-3900216) Mrtfa [nucleoplasm] (R-MMU-3900220) Mrtfa [cytosol] (R-MMU-5665975)	0.525	4

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