'ISGylated IRF3 [cytosol]' negatively regulates 'PIN1 mediated IRF3 degradation'

Stable Identifier
R-HSA-1176076
Type
NegativeRegulation
Locations in the PathwayBrowser
Summation

The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.

Literature References
PubMed ID Title Journal Year
16914094 ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation Cell Mol Biol (Noisy-le-grand) 2006
Regulation participants
Regulation type
NegativeRegulation