Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

Stable Identifier
R-HSA-1181153
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
4/5
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Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B
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Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1B (ALK4) (Attisano et al. 1996, Zhou et al. 2000). Activin appears to interact initially with the type II receptor component (Attisano et al. 1996). It is unclear if the type II and type I receptors are associated before binding Activin. Any of Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), and Activin B (INHBB:INHBB) can bind and signal via an activin receptor containing the ACVR1B (ALK4) type I receptor. Also, TGFBR3 (Betaglycan) antagonises Activin signalling by binding with Inhibin A and ACVR2A (ActRII). TGFBR3 and Activin compete for ACVR2A and TGFBR3 thus inhibits activin signalling (Lewis et al. 2000, Waiter et al. 2003).
Literature References
PubMed ID Title Journal Year
8196624 Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

Carcamo, J, Weis, FM, Ventura, F, Wieser, R, Wrana, JL, Attisano, L, Massague, J

Mol Cell Biol 1994
11117535 Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

Zhou, Y, Sun, H, Danila, DC, Johnson, SR, Sigai, DP, Zhang, X, Klibanski, A

Mol Endocrinol 2000
9032295 Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

Lebrun, JJ, Vale, WW

Mol Cell Biol 1997
8622651 Activation of signalling by the activin receptor complex

Attisano, L, Wrana, JL, Montalvo, E, Massague, J

Mol Cell Biol 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
Orthologous Events
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Canis familiaris)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Danio rerio)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Drosophila melanogaster)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Rattus norvegicus)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Sus scrofa)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)
Authored
May, B  (2011-01-23)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2011-01-28)
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