p-6Y-EGFR E746_A750del [plasma membrane]

Stable Identifier
R-HSA-1181214
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Phosphorylated Epidermal Growth Factor Receptor E746_A750del, p-6Y-EGFR Glu746_Ala750del
p-6Y-EGFR E746_A750del [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17349580 Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity

Li, Y, Meyerson, M, Woo, MS, Boggon, TJ, Greulich, H, Eck, MJ, Yun, CH

Cancer Cell 2007
External Reference Information
External Reference
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Other Identifiers
11725102_at
11725103_s_at
11725104_a_at
11733760_a_at
11738815_at
11742247_a_at
11751983_a_at
1537_at
1565483_PM_at
1565483_at
1565484_PM_x_at
1565484_x_at
17046135
1956
201983_PM_s_at
201983_s_at
201984_PM_s_at
201984_s_at
210984_PM_x_at
210984_x_at
211550_PM_at
211550_at
211607_PM_x_at
211607_x_at
224999_PM_at
224999_at
3002641
3002642
3002729
3002731
3002733
3002738
3002741
3002743
3002747
3002749
3002750
3002751
3002753
3002757
3002760
3002761
3002763
3002767
3002769
3002770
3002771
3002775
3002776
3002778
3002779
3002786
3002798
3002800
3002801
3002802
3002806
3002807
3002808
3002811
3002812
3002813
3002814
3002815
3002816
3002817
3002818
3002819
3002820
3002821
3002822
3002823
3002824
3002825
37327_at
48285_at
65700_at
8132860
A_14_P106592
A_23_P215790
A_33_P3351944
A_33_P3351955
GE59632
GO:0000139
GO:0000165
GO:0000166
GO:0000278
GO:0000902
GO:0001503
GO:0001618
GO:0001892
GO:0001934
GO:0001942
GO:0003677
GO:0003682
GO:0003690
GO:0003824
GO:0004672
GO:0004709
GO:0004713
GO:0004714
GO:0004888
GO:0005006
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005925
GO:0006260
GO:0006281
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007202
GO:0007435
GO:0007611
GO:0008092
GO:0008283
GO:0008284
GO:0008544
GO:0009925
GO:0009986
GO:0010008
GO:0010750
GO:0012501
GO:0014066
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016740
GO:0018108
GO:0019899
GO:0019900
GO:0019903
GO:0021795
GO:0022008
GO:0023052
GO:0030054
GO:0030139
GO:0030154
GO:0030163
GO:0030235
GO:0030296
GO:0030297
GO:0030307
GO:0030335
GO:0030669
GO:0031410
GO:0031625
GO:0031901
GO:0031965
GO:0032587
GO:0032991
GO:0033138
GO:0033674
GO:0034614
GO:0036211
GO:0038083
GO:0038127
GO:0038134
GO:0042059
GO:0042127
GO:0042177
GO:0042327
GO:0042802
GO:0043066
GO:0043226
GO:0043235
GO:0043406
GO:0045121
GO:0045296
GO:0045737
GO:0045739
GO:0045740
GO:0045893
GO:0045944
GO:0046328
GO:0046718
GO:0046777
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050730
GO:0050790
GO:0050877
GO:0050999
GO:0051015
GO:0051117
GO:0051205
GO:0051897
GO:0060089
GO:0060571
GO:0061024
GO:0061029
GO:0070141
GO:0070372
GO:0070374
GO:0070435
GO:0071230
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0072659
GO:0090263
GO:0097489
GO:0097708
GO:0098590
GO:0098609
GO:0098772
GO:0140096
GO:1900020
GO:1900087
GO:1901224
GO:1902895
GO:1903078
GO:1905208
HMNXSV003006702
HMNXSV003057307
Hs.279898.0.S1_3p_at
Hs.77432.0.S1_3p_a_at
Hs2.367845.1.S1_3p_at
Hs2.367845.1.S1_3p_x_at
ILMN_1696521
ILMN_1728858
ILMN_1755535
ILMN_1798975
PH_hs_0004462
PH_hs_0014421
TC07000328.hg
TC07002321.hg
TC07002322.hg
X00588_at
g12002211_3p_at
g1628549_3p_s_at
g4885198_3p_a_at
p26428
Participates
Other forms of this molecule
Modified Residues
Name
O4'-phospho-L-tyrosine at 1092
Coordinate
1092
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1172
Coordinate
1172
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1197
Coordinate
1197
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1110
Coordinate
1110
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1016
Coordinate
1016
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1069
Coordinate
1069
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
Deletion of residues 746 to 750
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
5WB7, 6V5P, 7LEN, 5GNK, 6P8Q, 2ITW, 4ZJV, 5FED, 3PFV, 7A6K, 4WRG, 3W2O, 4KRP, 2N5S, 6S9B, 5X2A, 4LL0, 6JRX, 6TFV, 5SX4, 6D8E, 3W2R, 7ER2, 7SYE, 6TFU, 3B2U, 2ITQ, 6LUD, 4I22, 1M14, 8HGO, 3G5Y, 6JWL, 7ZYQ, 4LRM, 2EB3, 1XKK, 6TG1, 5J9Y, 4R3R, 2KS1, 6TG0, 5WB8, 8D76, 5HCX, 5CZI, 5LV6, 7LTX, 3P0Y, 3NJP, 4RJ5, 5EM8, 7ZYM, 2GS7, 5CAN, 6S9C, 2RF9, 7SZ0, 6P1L, 5CAV, 3VJO, 7U9A, 5EDR, 2JIU, 7LFR, 5FEQ, 5CZH, 7JXM, 5EM7, 4RJ6, 8A2A, 5CAL, 4G5P, 4JQ7, 5XDK, 5CAU, 5UWD, 5UGC, 5EDQ, 4TKS, 4KRL, 5SX5, 4HJO, 5X2C, 7OM4, 4RIW, 6S9D, 7T4I, 6VHP, 3W2P, 2ITX, 4I1Z, 6VHN, 7SZ1, 7LFS, 4R5S, 7UKV, 6WAK, 3C09, 6V6K, 5Y9T, 5ZTO, 2RFD, 8HGP, 1IVO, 6JX0, 5XDL, 2ITT, 3B2V, 7AEI, 6WA2, 5U8L, 5J9Z, 4WKQ, 7KY0, 5C8K, 4JQ8, 5HCY, 7T4J, 6WXN, 2J5E, 5XGM, 6DUK, 7SZ5, 6XL4, 5CAO, 4I23, 3VRP, 4RJ7, 8A2B, 2JIV, 1YY9, 7JXP, 3W2S, 7TVD, 4UIP, 3BEL, 5ZWJ, 5C8N, 6V66, 5HCZ, 5X26, 4KRM, 8A27, 7ZYN, 7VRA, 7JXI, 6TFY, 2GS2, 5HG5, 3OB2, 6TFW, 7LG8, 7UKW, 2ITN, 7A6I, 4I20, 4RIX, 5HG7, 2J5F, 6Z4D, 6JX4, 8A2D, 6Z4B, 4JR3, 4ZAU, 5Y25, 5X27, 5C8M, 7SI1, 1M17, 5X2F, 6JRJ, 2RFE, 2ITU, 2J6M, 5CAP, 7SZ7, 6TFZ, 7K1H, 3UG1, 5CNO, 7A2A, 5XGN, 6S89, 7JXQ, 5HG8, 4WD5, 6LUB, 4I24, 2ITO, 3G5V, 5JEB, 5CNN, 7AEM, 7LGS, 3W32, 5HIB, 5GTY, 3LZB, 7U98, 3VRR, 7JXK, 3BUO, 6JXT, 5UG8, 2ITV, 4ZSE, 7ZYP, 4JRV, 5UG9, 6ARU, 3GOP, 7A6J, 2RGP, 4KRO, 2ITY, 4RIY, 2M0B, 8HGS, 6V6O, 4G5J, 6JZ0, 5GMP, 1Z9I, 3W2Q, 5X28, 7SYD, 3QWQ, 3UG2, 3GT8, 6JRK, 1MOX, 2EB2, 6B3S, 6VH4, 5X2K, 4RJ8, 7VRE, 5D41, 5HG9, 3OP0, 4R3P, 2M20, 6S8A, 5CAQ, 3W33, 8D73, 5YU9, 4I21, 7JXW, 3IKA, 7K1I, 6V5N, 7B85, 4RJ4, 7OXB, 4LQM, 2GS6, 5EM5, 5XWD, 3POZ, 2ITZ, 2JIT, 2ITP, 5EM6, 3VJN, 5UGA, 5HIC, 7U99, 1NQL, 5CAS, 5GTZ, 5FEE, 5EDP, 6P1D, 4LI5, 4UV7, 7KXZ, 7JXL, 5UGB
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (323)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.983 59
 UniProt:P00533 EGFR  20 0.981 29
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:P21860 ERBB3      0.919 14
 UniProt:P40763 STAT3  12 0.919 15
 UniProt:P12931 SRC  6 0.9 9
 UniProt:Q9UJM3 ERRFI      0.9 15
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:Q96CW1 AP2M1  6 0.828 8
 UniProt:P62158 CALM      0.828 6
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:Q06124 PTPN11  4 0.821 8
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P27986 PIK3R1  16 0.81 7
 UniProt:Q9UBN7 HDAC6  4 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  2 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P08107 HSP71      0.799 6
 UniProt:Q92625 ANS1A      0.793 7
 UniProt:P16885 PLCG2  8 0.793 6
 UniProt:Q16543 CDC37  1 0.786 13
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P07900 HSP90AA1  8 0.778 7
 UniProt:P42224 STAT1  8 0.774 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:Q92569 PIK3R3  2 0.76 7
 UniProt:O00459 PIK3R2  2 0.76 5
 UniProt:P46109 CRKL  2 0.749 5
 UniProt:P38646 HSP9  6 0.745 5
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:O60716 CTNND1  1 0.745 5
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:Q9UQB8 BAIAP2  1 0.735 4
 UniProt:Q13480 GAB1  4 0.735 5
 UniProt:P12830 CDH1  8 0.735 4
 UniProt:Q13322 GRB10  2 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q12929 EPS8  1 0.713 4
 UniProt:Q9P0L0 VAPA  4 0.713 4
 UniProt:Q96B97 SH3KBP1  3 0.695 4
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P46108 CRK  1 0.692 4
 UniProt:Q13239 SLA  1 0.692 3
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:P51451 BLK  2 0.692 3
 UniProt:P00519 ABL1  5 0.692 3
 UniProt:Q8TF42 UBS3B      0.69 7
 UniProt:P16234 PDGFRA  20 0.683 4
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:P41240 CSK  2 0.681 3
 UniProt:O75368 SH3L1      0.681 3
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:P35221 CTNNA1  2 0.68 5
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:O95782 AP2A1  5 0.671 6
 UniProt:Q9UQC2 GAB2  5 0.669 3
 UniProt:Q07889 SOS1  3 0.669 3
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:P06493 CDK1  11 0.667 3
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:P08631 HCK  2 0.653 3
 UniProt:Q9NZM3 ITSN2  1 0.653 3
 UniProt:Q15750 TAB1  6 0.653 3
 UniProt:P15311 EZR  3 0.653 3
 UniProt:P14923 JUP  6 0.653 3
 UniProt:Q10567 AP1B1  5 0.649 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P16615 ATP2A2  2 0.643 3
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:P42229 STAT5A  4 0.635 4
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:Q02952 AKAP12  1 0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:Q14457 BECN1  4 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q13438 OS9  1 0.623 3
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:P04792 HSBP1  3 0.615 3
 UniProt:Q99075 HBEGF  8 0.609 3
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P60033 CD81  1 0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:Q8IZW8 TNS4  1 0.59 2
 UniProt:P07355 ANXA2  4 0.583 4
 UniProt:O75886 STAM2  2 0.583 3
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:O14965 AURKA  6 0.581 4
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q9UKG1 APPL1  1 0.571 3
 UniProt:Q9Y6R0 NUMBL      0.571 2
 UniProt:P49757 NUMB  1 0.571 2
 UniProt:P07992 ERCC1  2 0.571 21
 UniProt:Q9UBS4 DNAJB11  1 0.569 3
 IntAct:EBI-11820565 HSPA1A      0.569 3
 UniProt:P63010 AP2B1  4 0.569 5
 UniProt:P53680 AP2S1  4 0.569 3
 UniProt:O94973 AP2A2  6 0.569 4
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:Q15303 ERBB4      0.564 3
 UniProt:Q13451 FKBP5  2 0.564 2
 UniProt:P07947 YES1  2 0.564 3
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:P60880 SNAP25  7 0.553 2
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:Q05513 PRKCZ  5 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:Q13153 PAK1  6 0.553 2
 UniProt:Q99963 SH3GL3  1 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:P37840 SNCA  5 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:P31749 AKT1  13 0.553 2
 UniProt:P16152 CBR1  1 0.553 2
 UniProt:Q16620 NTRK2  6 0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q06830 PRDX1  3 0.553 2
 UniProt:P30307 CDC25C  8 0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:O14543 SOCS3  1 0.553 2