Reactome | NR2F2 [nucleoplasm]

NR2F2 [nucleoplasm]

Stable Identifier

R-HSA-1183002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COUP transcription factor 2, COT2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P24468 NR2F2

Gene Names

NR2F2, ARP1, TFCOUP2

Chain

chain:1-414

Reference Genes

BioGPS Gene:7026 NR2F2

COSMIC (genes):NR2F2 NR2F2

CTD Gene:7026 NR2F2

dbSNP Gene:7026 NR2F2

ENSEMBL:ENSG00000185551 NR2F2

ENSEMBL_homo_sapiens_GENE:ENSG00000185551.15 NR2F2

HGNC:7976 NR2F2

KEGG Gene (Homo sapiens):7026 NR2F2

Monarch:7026 NR2F2

NCBI Gene:7026 NR2F2

OMIM:107773 NR2F2

UCSC:P24468 NR2F2

Reference Transcript

Other Identifiers

11723986_s_at

11723987_a_at

11723988_a_at

16805422

209119_PM_x_at

209119_x_at

209120_PM_at

209120_at

209121_PM_x_at

209121_x_at

215073_PM_s_at

215073_s_at

229092_PM_at

229092_at

3610159

3610160

3610165

3610166

3610167

3610168

3610169

3610170

3610171

3610172

3610173

3610174

3610175

3610176

3610177

3610178

3610179

3610180

3610182

3610186

3610187

3610188

3610189

3610190

3610191

3610202

3610203

3610205

3610207

3610208

3610209

39397_at

47529_at

7026

7986329

A_14_P110742

A_14_P137609

A_23_P88589

A_24_P313354

GE58035

GE63108

GE85771

GE874987

GO:0000122

GO:0000978

GO:0001701

GO:0001764

GO:0001893

GO:0001937

GO:0001945

GO:0001972

GO:0003013

GO:0003084

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0007519

GO:0008270

GO:0008289

GO:0008585

GO:0009566

GO:0009952

GO:0009956

GO:0010596

GO:0022414

GO:0023052

GO:0030154

GO:0030522

GO:0030900

GO:0032355

GO:0036211

GO:0042803

GO:0043226

GO:0043565

GO:0045736

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048514

GO:0048856

GO:0048870

GO:0060089

GO:0060674

GO:0060707

GO:0060838

GO:0140110

GO:1904936

HMNXSV003022060

HMNXSV003026881

Hs.288869.0.S1_3p_a_at

Hs.288869.0.S1_3p_x_at

Hs.288869.0.S3_3p_at

Hs.288869.1.S1_3p_a_at

Hs.91954.0.A1_3p_at

ILMN_1745785

ILMN_2094360

M64497_at

PH_hs_0016756

TC15000936.hg

g179023_3p_a_at

This entity regulates

Negatively

Expression of PPARG (Homo sapiens)

Cross References

RefSeq

NP_066285.1, NP_001138628.1, NP_001138627.1, NP_001138629.1

Guide to Pharmacology - Targets

618

OpenTargets

ENSG00000185551

HPA

ENSG00000185551-NR2F2

GeneCards

P24468

Ensembl

ENSP00000377726, ENSP00000401674, ENST00000394171, ENSP00000377721, ENSG00000185551, ENST00000394166, ENST00000453270, ENST00000421109, ENSP00000389853

PRO

P24468

Pharos - Targets

P24468

Orphanet

22884

PDB

3CJW

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10588 NR2F6	1	NR2F6 [nucleoplasm] (R-HSA-376279)	0.623	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.591	4
UniProt:Q9NUM3 S39A9			0.527	2
UniProt:P41587 VIPR2	1	VIPR2 [plasma membrane] (R-HSA-420227)	0.527	2
UniProt:O95274 LYPD3	2	cleaved GPI-LYPD3 [extracellular region] (R-HSA-8941013) GPI-LYPD3 [plasma membrane] (R-HSA-8940752)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:Q9H813 PACC1			0.527	2
UniProt:Q9UBV4 WNT16	9	WNT16 [extracellular region] (R-HSA-517474) N4GlycoAsn-PalmS WNT16 [extracellular exosome] (R-HSA-3781988) N4GlycoAsn-PalmS WNT16 [endocytic vesicle membrane] (R-HSA-3781977) WNT16 [endoplasmic reticulum lumen] (R-HSA-3238283) N4GlycoAsn-WNT16 [endoplasmic reticulum lumen] (R-HSA-3238224) N4GlycoAsn-PalmS WNT16 [endoplasmic reticulum lumen] (R-HSA-3238337) N4GlycoAsn-PalmS WNT16 [Golgi lumen] (R-HSA-3247814) N4GlycoAsn-PalmS WNT16 [extracellular region] (R-HSA-3247802) N4GlycoAsn-PalmS WNT16 [plasma membrane] (R-HSA-3247826)	0.527	2
UniProt:P54219 SLC18A1	1	SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-444153)	0.527	2
UniProt:O43567 RNF13			0.527	3
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	2
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:O15442 MPPD1			0.527	2
UniProt:Q8TD20 SLC2A12	1	SLC2A12 [plasma membrane] (R-HSA-429046)	0.527	2
UniProt:P21589 NT5E	1	NT5E [plasma membrane] (R-HSA-49191)	0.527	2
UniProt:Q9Y467 SALL2			0.527	2
UniProt:P31751 AKT2	7	p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056) p-T309-AKT2 [cytosol] (R-HSA-202066) AKT2 [cytosol] (R-HSA-49859) AKT2 [plasma membrane] (R-HSA-202053) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087)	0.527	2
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:Q9UHJ6 SHPK	1	SHPK [cytosol] (R-HSA-8959710)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.527	2
UniProt:P02774 GC	3	GC [lysosomal lumen] (R-HSA-350137) GC [cytosol] (R-HSA-209929) GC [extracellular region] (R-HSA-209886)	0.527	2
UniProt:P43119 PTGIR	1	PTGIR [plasma membrane] (R-HSA-391834)	0.527	2

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