Reactome | Expression of Leptin

Expression of Leptin

Stable Identifier

R-HSA-1183003

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm, extracellular region

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The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
12213831	Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter Melzner, I, Scott, V, Dorsch, K, Fischer, P, Wabitsch, M, Bruderlein, S, Hasel, C, Moller, P	J Biol Chem	2002
8770873	Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma De Vos, P, Lefebvre, AM, Miller, SG, Guerre-Millo, M, Wong, K, Saladin, R, Hamann, LG, Staels, B, Briggs, MR, Auwerx, J	J Clin Invest	1996
8643605	The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression Miller, SG, De Vos, P, Guerre-Millo, M, Wong, K, Hermann, T, Staels, B, Briggs, MR, Auwerx, J	Proc Natl Acad Sci U S A	1996