The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996).
Melzner, I, Scott, V, Dorsch, K, Fischer, P, Wabitsch, M, Bruderlein, S, Hasel, C, Moller, P
De Vos, P, Lefebvre, AM, Miller, SG, Guerre-Millo, M, Wong, K, Saladin, R, Hamann, LG, Staels, B, Briggs, MR, Auwerx, J
Miller, SG, De Vos, P, Guerre-Millo, M, Wong, K, Hermann, T, Staels, B, Briggs, MR, Auwerx, J
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