Reactome | ADIPOQ [extracellular region]

ADIPOQ [extracellular region]

Stable Identifier

R-HSA-1183052

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Adiponectin, ADIPO_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        ADIPOQ gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
        
        ADIPOQ [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15848 ADIPOQ

Gene Names

ADIPOQ, ACDC, ACRP30, APM1, GBP28

Chain

signal peptide:1-18, chain:19-244

Reference Genes

BioGPS Gene:9370 ADIPOQ

COSMIC (genes):ADIPOQ ADIPOQ

CTD Gene:9370 ADIPOQ

dbSNP Gene:9370 ADIPOQ

ENSEMBL:ENSG00000181092 ADIPOQ

HGNC:13633 ADIPOQ

KEGG:hsa:9370 ADIPOQ

Monarch:9370 ADIPOQ

NCBI Gene:9370 ADIPOQ

OMIM:605441 ADIPOQ

UCSC:Q15848 ADIPOQ

Reference Transcript

Other Identifiers

11734558_a_at

11734559_x_at

11734560_x_at

11752564_x_at

16949397

207175_PM_at

207175_at

2656802

2656820

2656821

2656822

2656823

2656824

2656825

40657_r_at

40658_r_at

8084710

9370

A_23_P369237

D45371_at

GE79959

GO:0001666

GO:0001934

GO:0005102

GO:0005125

GO:0005179

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005783

GO:0005975

GO:0006006

GO:0006091

GO:0006355

GO:0006629

GO:0006635

GO:0007165

GO:0007584

GO:0007623

GO:0009410

GO:0009617

GO:0009744

GO:0009749

GO:0009967

GO:0009986

GO:0010467

GO:0010642

GO:0010739

GO:0010745

GO:0010804

GO:0010875

GO:0010906

GO:0014823

GO:0019395

GO:0030154

GO:0030312

GO:0030336

GO:0030853

GO:0031012

GO:0031667

GO:0031953

GO:0032720

GO:0032757

GO:0032869

GO:0032991

GO:0033034

GO:0033691

GO:0034115

GO:0034383

GO:0034612

GO:0042593

GO:0042802

GO:0042803

GO:0043123

GO:0043124

GO:0043226

GO:0043407

GO:0043539

GO:0045471

GO:0045599

GO:0045650

GO:0045721

GO:0045776

GO:0045892

GO:0045923

GO:0046326

GO:0046888

GO:0048018

GO:0050728

GO:0050731

GO:0050765

GO:0050805

GO:0050873

GO:0051384

GO:0062023

GO:0070373

GO:0070543

GO:0070994

GO:0071320

GO:0071466

GO:0071639

GO:0071872

GO:0072659

GO:0090317

GO:0098772

GO:0110113

GO:0120162

GO:0120163

GO:1900121

GO:1904706

GO:1904753

GO:1905598

GO:2000279

GO:2000467

GO:2000478

GO:2000481

GO:2000534

GO:2000584

GO:2000590

HMNXSV003030614

ILMN_1775045

PH_hs_0027709

TC03001027.hg

g4757759_3p_at

Participates

as an output of

as a component of

ADIPOQ trimer [extracellular region] (Homo sapiens)

Inferred To

Adipoq [extracellular region] (Mus musculus)

Adipoq [extracellular region] (Rattus norvegicus)

adipoqb [extracellular region] (Danio rerio)

adipoq [extracellular region] (Xenopus tropicalis)

ADID [extracellular region] (Canis familiaris)

ADIPOQ [extracellular region] (Bos taurus)

ADIPOQ [extracellular region] (Gallus gallus)

ADIPOQ [extracellular region] (Sus scrofa)

Cross References

OpenTargets

ENSG00000181092

ENSEMBL

ENSG00000181092, ENSP00000320709, ENSP00000389814, ENST00000320741, ENST00000444204

GeneCards

ADIPOQ

HPA

ENSG00000181092-ADIPOQ

PRO

Q15848

Pharos - Targets

Q15848

HMDB Protein

HMDBP02512

PDB

6U6N, 6U66, 4DOU

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.781	7
UniProt:Q8N205-2 SYNE4			0.718	6
UniProt:A1A5C7-2 SLC22A23			0.556	3
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.556	3
UniProt:Q9UPQ4-2 Q9UPQ42			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:P15941-11 MUC1			0.556	3
UniProt:Q53FP2 NACHO			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:O14524-2 NEMP1			0.556	3
UniProt:P07307-3 ASGR2			0.556	3
UniProt:P38484 IFNGR2	1	IFNGR2 [plasma membrane] (R-HSA-629620)	0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:P30040 ERP29			0.556	3
IntAct:EBI-23184686 CCSB ORF ID			0.556	3
UniProt:Q8NFJ6 PROKR2	1	PROKR2 [plasma membrane] (R-HSA-444637)	0.556	3
UniProt:Q96PQ1 SIGLEC12	1	SIGLEC12 [plasma membrane] (R-HSA-197729)	0.556	3
UniProt:O60238 BNIP3L	1	BNIP3L [mitochondrial outer membrane] (R-HSA-6798001)	0.556	3
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-54659) decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-199233)	0.556	3
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q8IUN9 CLEC10A	1	CLEC10A [plasma membrane] (R-HSA-1472863)	0.556	3
UniProt:Q13323 BIK			0.556	3
UniProt:Q9UHP7-3 CLEC2D			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:O75208 COQ9	1	COQ9 [mitochondrial inner membrane] (R-HSA-8932994)	0.556	3
UniProt:Q6ZSS7 MFSD6			0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:O95279 KCNK5	1	KCNK5 [plasma membrane] (R-HSA-1296323)	0.556	3
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.556	3
UniProt:Q7Z769 S35E3			0.556	3
UniProt:Q5SR56 MF14B			0.556	3
UniProt:Q8WV48 CC107			0.556	3
UniProt:Q6UXG8-3 Q6UXG83			0.556	3
UniProt:Q9BQA9 CYBC1			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q9NQQ7-3 Q9NQQ73			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q96A49 SYAP1			0.556	3
UniProt:O43557 TNFSF14	1	TNFSF14 [plasma membrane] (R-HSA-5667149)	0.556	3
UniProt:Q8TD46-4 CD200R1			0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.556	3
UniProt:Q9GZY8-5 MFF			0.556	3
UniProt:Q7Z7N9 TMEM179B	4	TMEM179B [ficolin-1-rich granule membrane] (R-HSA-6800989) TMEM179B [secretory granule membrane] (R-HSA-6801009) TMEM179B [plasma membrane] (R-HSA-6806263) TMEM179B [azurophil granule membrane] (R-HSA-6799362)	0.556	3
UniProt:P23276 KEL	1	KEL [plasma membrane] (R-HSA-5694121)	0.556	3
UniProt:O95484 CLDN9	2	CLDN9 [plasma membrane] (R-HSA-420016) CLDN9 [cell junction] (R-HSA-421271)	0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q86WK6 AMGO1			0.556	3
UniProt:Q96HJ5 MS4A3	2	MS4A3 [plasma membrane] (R-HSA-6806321) MS4A3 [specific granule membrane] (R-HSA-6799514)	0.556	3
UniProt:P34972 CNR2	1	CNR2 [plasma membrane] (R-HSA-419372)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:P12314 FCGR1A	3	FCGR1A [clathrin-coated endocytic vesicle membrane] (R-HSA-1236781) FCGR1A [early endosome membrane] (R-HSA-1236890) FCGR1A [plasma membrane] (R-HSA-197835)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3

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