Reactome: A Curated Pathway Database

Expression of Adiponectin

Stable Identifier
R-HSA-1183058
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Summation

The Adiponectin gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Expression of Adiponectin is upregulated during adipogenesis by C/EBPalpha (CEBPA), PPARG, and CEBPB (Segawa et al. 2009, Qiao et al. 2005, Iwaki et al. 2003, Kita et al. 2005).

Literature References
PubMed ID Title Journal Year
15850785 Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha Biochem Biophys Res Commun 2005
18931025 Identification of a novel distal enhancer in human adiponectin gene J Endocrinol 2009
15919796 C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer Diabetes 2005
12829629 Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors Diabetes 2003
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Positive Regulation
 
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