Reactome | Expression of Adiponectin

Expression of Adiponectin

Stable Identifier

R-HSA-1183058

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

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Summation

The Adiponectin gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Expression of Adiponectin is upregulated during adipogenesis by C/EBPalpha (CEBPA), PPARG, and CEBPB (Segawa et al. 2009, Qiao et al. 2005, Iwaki et al. 2003, Kita et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15850785	Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha	Biochem Biophys Res Commun	2005
18931025	Identification of a novel distal enhancer in human adiponectin gene	J Endocrinol	2009
15919796	C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer	Diabetes	2005
12829629	Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors	Diabetes	2003

Participants

Input

ADIPOQ gene [nucleoplasm] (Homo sapiens)

Output

ADIPOQ [extracellular region] (Homo sapiens)

Participant Of

hasEvent

Transcriptional regulation of white adipocyte differentiation

This entity is regulated by

Positive Regulation