Reactome: A Curated Pathway Database

PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins

Stable Identifier
R-HSA-1183128
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Protein citrullination
Locations in the PathwayBrowser
Summation

Methylation of histones by protein arginine methyltransferases (PRMTs), in general, is required for mammalian development and plays an important and dynamic role in gene regulation. Protein-arginine deiminases (PADIs) catalyse the deimination of L-arginine residues (L-Arg) in proteins to L-citrulline (L-Cit), thus playing a role in the regulation of development (Guerrin et al. 2003, Ishigami et al. 2002, Kanno et al. 2000, Wang et al. 2004, Nakayama-Hamada et al. 2005, Chavanas et al. 2004).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein-arginine deiminase activity of PADIs:Ca2+ [cytosol] PADIs:Ca2+ [cytosol] protein-arginine deiminase activity (0004668)
Orthologous Events