Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
EHMT1 [nucleoplasm]
Stable Identifier
R-HSA-1183226
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, EHMT1_HUMAN, KMT1D, G9a-like protein 1, GLP1, GLP
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Ub-EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
Sensory Perception (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
Expression and translocation of olfactory receptors (Homo sapiens)
Expression of Olfactory Receptor (Homo sapiens)
EHMT1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H9B1 EHMT1
Gene Names
EHMT1, EUHMTASE1, GLP, KIAA1876, KMT1D
Chain
initiator methionine:1, chain:2-1298
Reference Genes
BioGPS Gene:79813 EHMT1
COSMIC (genes):EHMT1 EHMT1
CTD Gene:79813 EHMT1
dbSNP Gene:79813 EHMT1
ENSEMBL:ENSG00000181090 EHMT1
ENSEMBL:ENSG00000181090.21 EHMT1
HGNC:24650 EHMT1
KEGG Gene (Homo sapiens):79813 EHMT1
Monarch:79813 EHMT1
NCBI Gene:79813 EHMT1
OMIM:607001 EHMT1
UCSC:Q9H9B1 EHMT1
Reference Transcript
RefSeq:NM_001145527.1 EHMT1
RefSeq:NM_024757.4 EHMT1
Other Identifiers
11743700_a_at
11754730_a_at
11756805_a_at
17091769
219339_PM_s_at
219339_s_at
222873_PM_s_at
222873_s_at
225461_PM_at
225461_at
3195418
3195421
3195422
3195430
3195441
3195443
3195448
3195449
3195450
3195451
3195456
3195465
3195467
3195468
3195469
3195471
3195473
3195475
3195476
3195483
3195484
3195485
3195486
3195487
3195491
3195494
3195503
3195504
3195505
3195506
3195507
3195511
3195513
3195514
3195515
3195524
3195525
3195526
3195527
3195528
3195529
52640_at
55980_i_at
55981_f_at
64700_at
79813
8159702
82086_at
89907_at
A_23_P20894
A_23_P217120
A_33_P3286387
GE62293
GE731872
GE87900
GO:0000122
GO:0000785
GO:0001222
GO:0002039
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006306
GO:0006325
GO:0006351
GO:0006355
GO:0008168
GO:0008270
GO:0016279
GO:0016604
GO:0016740
GO:0018024
GO:0018026
GO:0018027
GO:0032259
GO:0034968
GO:0036211
GO:0043226
GO:0045892
GO:0045995
GO:0046872
GO:0046974
GO:0046976
GO:0048856
GO:0060992
GO:0070742
GO:0120162
GO:0140096
GO:0140718
GO:0140947
HMNXSV003050668
HMNXSV003051283
Hs.127236.0.S1_3p_a_at
Hs.127236.1.S1_3p_at
Hs.127236.1.S1_3p_x_at
ILMN_1706418
ILMN_1812273
PH_hs_0025056
TC09000852.hg
g13376092_3p_a_at
Participates
as a component of
Ub-EHMT1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
Inferred To
EHMT1 [nucleoplasm]
(Bos taurus)
EHMT1 [nucleoplasm]
(Canis familiaris)
EHMT1 [nucleoplasm]
(Danio rerio)
EHMT1 [nucleoplasm]
(Gallus gallus)
EHMT1 [nucleoplasm]
(Mus musculus)
EHMT1 [nucleoplasm]
(Sus scrofa)
ehmt1 [nucleoplasm]
(Xenopus tropicalis)
Ehmt1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of EHMT1 [nucleoplasm]
(Dictyostelium discoideum)
G9a [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001138999.1
,
NP_079033.4
Guide to Pharmacology - Targets
2651
OpenTargets
ENSG00000181090
GeneCards
Q9H9B1
HPA
ENSG00000181090-EHMT1
ZINC target
Q9H9B1
Ensembl
ENST00000460843
,
ENST00000371394
,
ENSP00000485945
,
ENSP00000417328
,
ENST00000462484
,
ENSG00000181090
,
ENSP00000417980
PRO
Q9H9B1
Pharos - Targets
Q9H9B1
Orphanet
19026
HMDB Protein
HMDBP00425
PDB
3SW9
,
5TTG
,
3FPD
,
5VSF
,
5TUZ
,
6BY9
,
3MO0
,
3B95
,
3B7B
,
6MBO
,
6MBP
,
2RFI
,
3HNA
,
3SWC
,
5V9J
,
3MO2
,
3MO5
,
2IGQ
,
7T7M
,
4I51
,
5VSD
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.725
4
UniProt:Q04207
6
Rela [nucleoplasm]
(R-MMU-177676)
Rela [cytosol]
(R-MMU-168172)
phospho-Rela [nucleoplasm]
(R-MMU-5624468)
phospho-Rela [nucleoplasm]
(R-MMU-5660642)
Rela [nucleoplasm]
(R-MMU-4755466)
Rela [nucleoplasm]
(R-MMU-8865233)
0.675
5
UniProt:Q9D752
1
Mad2l2 [nucleoplasm]
(R-MMU-59092)
0.564
2
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
2
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.527
4
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.499
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text