Reactome | WHSC1L1 [nucleoplasm]

WHSC1L1 [nucleoplasm]

Stable Identifier

R-HSA-1183230

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase NSD3, NSD3, KMT3F, WHISTLE

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BZ95 NSD3

Gene Names

NSD3, WHSC1L1, DC28

Chain

chain:1-1437

Reference Genes

BioGPS Gene:54904 Q9BZ953

COSMIC (genes):NSD3 NSD3

CTD Gene:54904 Q9BZ953

dbSNP Gene:54904 Q9BZ953

ENSEMBL:ENSG00000147548 NSD3

HGNC:12767 Q9BZ953

KEGG:hsa:54904 Q9BZ953

Monarch:54904 Q9BZ953

NCBI Gene:54904 Q9BZ953

OMIM:607083 Q9BZ953

UCSC:Q9BZ95 Q9BZ953

Reference Transcript

Participates

as a member of

Inferred To

SET2 [nucleoplasm] (Saccharomyces cerevisiae)

set2 [nucleoplasm] (Schizosaccharomyces pombe)

NSD3 [nucleoplasm] (Bos taurus)

NSD3 [nucleoplasm] (Canis familiaris)

NSD3 [nucleoplasm] (Sus scrofa)

WHSC1L1 [nucleoplasm] (Dictyostelium discoideum)

WHSC1L1 [nucleoplasm] (Plasmodium falciparum)

Nsd3 [nucleoplasm] (Mus musculus)

Nsd3 [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000147548

ENSEMBL

ENSG00000147548, ENST00000527502, ENSP00000313410, ENSP00000313983, ENSP00000393284, ENST00000433384, ENSP00000434730, ENST00000316985, ENST00000317025

IntEnz

2.1.1.371, 2.1.1.370

HPA

ENSG00000147548-NSD3

GeneCards

NSD3

PRO

Q9BZ95

Pharos - Targets

Q9BZ95

GlyGen

Q9BZ95

HMDB Protein

HMDBP09023

PDB

7CRP, 6G2E, 6G2F, 7CRQ, 6G2B, 6G2C, 6CEN, 6G2O, 5UPD, 7CRR, 6G3P, 6G27, 4GNG, 2ND1, 6G24, 6G3T, 6G29, 6G25, 4GND, 2DAQ, 4GNF, 2NCZ, 7JYN, 4GNE, 4RXJ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.573	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.547	3
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.543	4
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.508	3
UniProt:O95391 SLU7	1	hSLU7 [nucleoplasm] (R-HSA-72073)	0.508	2
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.508	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.508	2

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