Reactome | EGFRvIII [plasma membrane]

EGFRvIII [plasma membrane]

Stable Identifier

R-HSA-1214162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EGFR V30_R297delinsG mutant, Epidermal Growth Factor Receptor V30_R297delinsG mutant, EGFR Val30_Arg297delinsGly mutant

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General

EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRvIII, is found in ~25% high-grade glioblastomas and can also be found in squamous cell carcinoma of the lung. EGFRvIII lacks the ligand biding domain and is constitutively active.

External Reference Information

External Reference

UniProt:P00533 EGFR

Gene Names

EGFR, ERBB, ERBB1, HER1

Chain

signal peptide:1-24, chain:25-1210

Reference Genes

BioGPS Gene:1956 EGFR

COSMIC (genes):EGFR EGFR

CTD Gene:1956 EGFR

dbSNP Gene:1956 EGFR

ENSEMBL:ENSG00000146648 EGFR

HGNC:3236 EGFR

KEGG Gene (Homo sapiens):1956 EGFR

Monarch:1956 EGFR

NCBI Gene:1956 EGFR

OMIM:131550 EGFR

UCSC:P00533 EGFR

Reference Transcript

Other Identifiers

0000840253

0002940025

0005900148

0006350504

11725102_at

11725103_s_at

11725104_a_at

11733760_a_at

11738815_at

11742247_a_at

11751983_a_at

1537_at

1565483_at

1565484_x_at

17046135

1956

201983_s_at

201984_s_at

210984_x_at

211550_at

211607_x_at

224999_at

3002641

3002642

3002729

3002731

3002733

3002738

3002741

3002743

3002747

3002749

3002750

3002751

3002753

3002757

3002760

3002761

3002763

3002767

3002769

3002770

3002771

3002775

3002776

3002778

3002779

3002786

3002798

3002800

3002801

3002802

3002806

3002807

3002808

3002811

3002812

3002813

3002814

3002815

3002816

3002817

3002818

3002819

3002820

3002821

3002822

3002823

3002824

3002825

37327_at

48285_at

65700_at

8132860

A_14_P106592

A_23_P215790

A_33_P3351944

A_33_P3351955

GE59632

GO:0000003

GO:0000139

GO:0000165

GO:0000166

GO:0000186

GO:0000278

GO:0000902

GO:0001503

GO:0001618

GO:0001889

GO:0001934

GO:0001942

GO:0003013

GO:0003674

GO:0003677

GO:0003682

GO:0003690

GO:0004672

GO:0004709

GO:0004713

GO:0004714

GO:0004888

GO:0005006

GO:0005102

GO:0005178

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005887

GO:0005925

GO:0006259

GO:0006357

GO:0006412

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0006970

GO:0006979

GO:0007049

GO:0007155

GO:0007165

GO:0007166

GO:0007169

GO:0007173

GO:0007202

GO:0007267

GO:0007275

GO:0007494

GO:0007611

GO:0007623

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009925

GO:0009986

GO:0010008

GO:0010750

GO:0010960

GO:0014066

GO:0014070

GO:0015031

GO:0016020

GO:0016021

GO:0016032

GO:0016101

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019058

GO:0019899

GO:0019900

GO:0019901

GO:0019903

GO:0030054

GO:0030139

GO:0030154

GO:0030234

GO:0030235

GO:0030307

GO:0030324

GO:0030335

GO:0030669

GO:0031410

GO:0031625

GO:0031901

GO:0031965

GO:0032355

GO:0032587

GO:0032930

GO:0032991

GO:0033138

GO:0033590

GO:0033594

GO:0033674

GO:0033993

GO:0034614

GO:0034641

GO:0035556

GO:0035690

GO:0038083

GO:0038128

GO:0040007

GO:0040011

GO:0042059

GO:0042060

GO:0042177

GO:0042327

GO:0042592

GO:0042698

GO:0042743

GO:0042802

GO:0043006

GO:0043066

GO:0043167

GO:0043226

GO:0043235

GO:0043406

GO:0043586

GO:0044403

GO:0044877

GO:0045121

GO:0045202

GO:0045296

GO:0045737

GO:0045739

GO:0045740

GO:0045746

GO:0045780

GO:0045893

GO:0045907

GO:0045930

GO:0045944

GO:0046328

GO:0046718

GO:0046777

GO:0048143

GO:0048408

GO:0048471

GO:0048661

GO:0048812

GO:0048856

GO:0048870

GO:0050679

GO:0050729

GO:0050730

GO:0050877

GO:0050999

GO:0051015

GO:0051117

GO:0051205

GO:0051592

GO:0051897

GO:0051968

GO:0060252

GO:0061024

GO:0070141

GO:0070257

GO:0070372

GO:0070374

GO:0070435

GO:0071260

GO:0071276

GO:0071363

GO:0071364

GO:0071392

GO:0071549

GO:0090263

GO:0097421

GO:0097489

GO:0097708

GO:0098609

GO:1900020

GO:1900087

GO:1901185

GO:1901224

GO:1902722

GO:1903078

GO:1903800

GO:1905208

GO:2000145

HMNXSV003006702

HMNXSV003057307

Hs.279898.0.S1_3p_at

Hs.77432.0.S1_3p_a_at

Hs2.367845.1.S1_3p_at

Hs2.367845.1.S1_3p_x_at

ILMN_1696521

ILMN_1728858

ILMN_1755535

ILMN_1798975

ILMN_1905285

PH_hs_0004462

PH_hs_0014421

TC07000328.hg

TC07002321.hg

TC07002322.hg

X00588_at

g12002211_3p_at

g1628549_3p_s_at

g4885198_3p_a_at

Participates

as an input of

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)

as a component of

EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]

p-5Y-EGFRvIII [plasma membrane]

p-6Y-EGFR E746_A750del;T790M [plasma membrane]

p-6Y-EGFR L858R;T790M [plasma membrane]

p-6Y-EGFR M766_A767insASV [plasma membrane]

p-6Y-EGFR D770_N771insNPH [plasma membrane]

p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]

p-6Y-EGFR D770_N771insNPG [plasma membrane]

p-6Y-EGFR E746_A750del [plasma membrane]

p-6Y-EGFR L858R [plasma membrane]

p-6Y-EGFR G719S [plasma membrane]

p-6Y-EGFR L747_P753delinsS [plasma membrane]

p-6Y-EGFR L747_A750delinsP [plasma membrane]

p-6Y-EGFR L747_T751del [plasma membrane]

p-6Y-EGFR L747_S752del [plasma membrane]

p-6Y-EGFR L747_T751delinsP [plasma membrane]

p-6Y-EGFR E746_T751delinsA [plasma membrane]

p-6Y-EGFR E746_S752delinsV [plasma membrane]

p-6Y-EGFR L861Q [plasma membrane]

p-6Y-EGFR A289V [plasma membrane]

p-6Y-EGFR T263P [plasma membrane]

p-6Y-EGFR G598V [plasma membrane]

p-6Y-EGFR R108K [plasma membrane]

p-6Y-EGFR A289T [plasma membrane]

p-6Y-EGFR G719C [plasma membrane]

p-6Y-EGFR A289D [plasma membrane]

p-6Y-EGFR G719A [plasma membrane]

EGFR L858R;T790M [plasma membrane]

EGFR E746_A750del;T790M [plasma membrane]

EGFR D770_N771insNPG [plasma membrane]

EGFR V738_K739insKIPVAI [plasma membrane]

EGFR M766_A767insASV [plasma membrane]

EGFR D770_N771insNPH [plasma membrane]

EGFR L858R [plasma membrane]

EGFR G719S [plasma membrane]

EGFR E746_A750del [plasma membrane]

EGFR L747_P753delinsS [plasma membrane]

EGFR A289V [plasma membrane]

EGFR L747_T751delinsP [plasma membrane]

EGFR L747_T751del [plasma membrane]

EGFR A289D [plasma membrane]

EGFR L861Q [plasma membrane]

EGFR R108K [plasma membrane]

EGFR L747_A750delinsP [plasma membrane]

EGFR E746_T751delinsA [plasma membrane]

EGFR G719A [plasma membrane]

EGFR A289T [plasma membrane]

EGFR E746_S752delinsV [plasma membrane]

EGFR G719C [plasma membrane]

EGFR T263P [plasma membrane]

EGFR G598V [plasma membrane]

EGFR L747_S752del [plasma membrane]

EGFR [endosome membrane]

p-4Y-EGFR [plasma membrane]

p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]

p-Y1086,Y1101-EGFR [plasma membrane]

EGFR [plasma membrane]

p-6Y-EGFR [plasma membrane]

Modified Residues

Name

Deletion of residues 30 to 296

Name

L-arginine 297 replaced with glycine

Coordinate

297

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

Disease

Name	Identifier	Synonyms
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
astrocytoma	DOID:3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
brain glioma	DOID:0060108
lung squamous cell carcinoma	DOID:3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung

Cross References

RefSeq

NP_958440.1, NP_958439.1, NP_958441.1, NP_005219.2

ZINC - World Drugs

EGFR_HUMAN

Guide to Pharmacology - Targets

1797

OpenTargets

ENSG00000146648

ZINC - FDA approved

EGFR_HUMAN

ZINC - Substances

EGFR_HUMAN

ZINC - Biogenic

EGFR_HUMAN

ZINC target

P00533

PRO

P00533

GlyGen

P00533

PDB

5CAU, 4WKQ, 5X2K, 6ARU, 5CZH, 1DNR, 5CNN, 2EB2, 5GMP, 5HCZ, 4LI5, 5ZWJ, 2JIV, 6TFZ, 6VHP, 2ITZ, 2EXQ, 3UG1, 6VHN, 6TFY, 5JEB, 4R5S, 2J5F, 5HCX, 4HJO, 6P1D, 6JZ0, 5X2C, 4JQ7, 3W33, 5LV6, 3W32, 5J9Y, 5CZI, 4LRM, 6S9D, 2ITU, 5HIB, 4RJ8, 4I23, 6TFW, 2ITT, 6TFV, 7A2A, 3VRP, 4I22, 5CAS, 3IKA, 4JRV, 4I20, 4LQM, 2ITP, 5EDR, 5YU9, 1XKK, 5GTY, 3OP0, 6S9B, 5HG9, 5GTZ, 5HCY, 4RJ6, 5UGC, 5X2F, 4G5P, 6VH4, 6JRX, 4G5J, 6S9C, 4TKS, 3NJP, 1Z9I, 1DNQ, 4UIP, 2EXP, 2JIU, 4KRP, 6V6O, 5Y9T, 2JIT, 3P0Y, 2N5S, 6V66, 6Z4B, 3OB2, 5EDP, 5UGA, 4RIY, 5ZTO, 2J5E, 5UWD, 5XGN, 4ZSE, 6TFU, 1IVO, 3BUO, 6LUD, 4WRG, 3W2S, 4RJ7, 3W2R, 5CAP, 3POZ, 5EM8, 5CAQ, 5D41, 6JRK, 4I21, 4KRO, 4R3R, 2ITQ, 4KRM, 5HG7, 4RJ4, 5EDQ, 4WD5, 4KRL, 5HG8, 4RJ5, 5UGB, 2ITO, 1YY9, 5EM6, 1NQL, 2ITN, 6Z4D, 1MOX, 3C09, 5X28, 3B2V, 6V6K, 4JR3, 6JXT, 2RFD, 4UV7, 5C8N, 5X2A, 3QWQ, 5XWD, 6P8Q, 4RIX, 2ITY, 6DUK, 6LUB, 5FEE, 2ITX, 5EM5, 6V5P, 6TG1, 3LZB, 5XDL, 2GS6, 5X26, 5CAN, 5CAO, 3BEL, 3G5Y, 3G5V, 5SX5, 5FEQ, 5EM7, 6S89, 3W2Q, 3VJO, 3GT8, 5UG8, 6JRJ, 4R3P, 6JX4, 3W2P, 5XGM, 6S8A, 4I1Z, 2EB3, 5WB8, 5CAV, 2J6M, 3PFV, 5C8K, 5CNO, 5U8L, 6JWL, 4ZAU, 6B3S, 5C8M, 5X27, 3B2U, 6D8E, 5UG9, 3UG2, 4RIW, 5Y25, 6TG0, 6V5N, 5WB7, 2RF9, 4LL0, 5FED, 4ZJV, 6P1L, 2M20, 5GNK, 2GS7, 4JQ8, 5CAL, 2ITW, 2KS1, 1M17, 5XDK, 2ITV, 5SX4, 4I24, 2RFE, 1M14, 5J9Z, 3VRR, 2GS2, 5HIC, 2M0B, 3GOP, 3VJN, 5HG5, 3W2O, 2RGP, 6JX0

ZINC - Investigational

EGFR_HUMAN

ZINC - Metabolites

EGFR_HUMAN

COSMIC

COSM21351

HPA

ENSG00000146648-EGFR

GeneCards

P00533

Ensembl

ENSP00000342376, ENST00000342916, ENST00000420316, ENST00000344576, ENSP00000345973, ENSP00000413843, ENSP00000275493, ENST00000275493, ENSG00000146648

Pharos - Targets

P00533

ZINC - Predictions - Purchasable

EGFR_HUMAN

Orphanet

15917

HMDB Protein

HMDBP01456

Interactors (284)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.981	29
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.981	56
UniProt:P29353 SHC1	5	p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276)	0.973	41
UniProt:P01133 EGF	5	Pro-EGF [extracellular region] (R-HSA-54209) Pro-EGF [plasma membrane] (R-HSA-179888) EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086) Pro-EGF [platelet alpha granule lumen] (R-HSA-139875) EGF [extracellular region] (R-HSA-179863)	0.973	29
UniProt:P22681 CBL	20	CBL G375fs16 [cytosol] (R-HSA-9706211) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL P417A [cytosol] (R-HSA-9706636) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL R420Q [cytosol] (R-HSA-9706186) CBL del366-477 [cytosol] (R-HSA-9706176) CBL H398Q [cytosol] (R-HSA-9706633) CBL R499L [cytosol] (R-HSA-9706678) CBL Y371H [cytosol] (R-HSA-9706680) CBL P417R [cytosol] (R-HSA-9706632) CBL L380P [cytosol] (R-HSA-9706630) CBL H398Y [cytosol] (R-HSA-9706639) CBL R499 [cytosol] (R-HSA-9706670) CBL S376F [cytosol] (R-HSA-9706643) CBL R420G [cytosol] (R-HSA-9706203) CBL G375P [cytosol] (R-HSA-9706219) CBL del366-409 [cytosol] (R-HSA-9706179) CBL P417L [cytosol] (R-HSA-9706634)	0.964	26
UniProt:P04626 ERBB2	20	p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) ERBB2 G309E [plasma membrane] (R-HSA-9665342) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) ERBB2 G309A [plasma membrane] (R-HSA-9665349)	0.954	25
UniProt:P40763 STAT3	12	p-STAT3 [nucleoplasm] (R-HSA-8983188) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-STAT3 [cytosol] (R-HSA-8982823) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-914048)	0.919	15
UniProt:P21860 ERBB3			0.91	13
UniProt:P12931 SRC	6	MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y416-SRC [cytosol] (R-HSA-8964276) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.9	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.89	10
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.864	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.854	7
UniProt:P19174 PLCG1	6	p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y-PLCG1 [cytosol] (R-HSA-9029082) PLCG1 [cytosol] (R-HSA-202320) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682)	0.85	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.833	9
UniProt:Q9UJM3 ERRFI			0.826	13
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.82	7
UniProt:P15941 MUC1	19	MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359)	0.819	6
UniProt:Q03135 CAV1	5	CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [Golgi membrane] (R-HSA-204504)	0.813	7
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.811	10
UniProt:Q9UBN7 HDAC6	5	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980)	0.809	12
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.807	5
UniProt:P11142 HSPA8	10	HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [cytosol] (R-HSA-264476)	0.803	7
UniProt:P20417	1	Ptpn1 [cytosol] (R-RNO-210625)	0.802	11
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180)	0.8	8
UniProt:P08107 HSP71			0.799	6
UniProt:P16885 PLCG2	10	PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [cytosol] (R-HSA-984806) p-Y-PLCG2 [cytosol] (R-HSA-9029105) p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) PLCG2 [plasma membrane] (R-HSA-2023875)	0.793	6
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.785	7
UniProt:P10599 TXN	4	2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732)	0.785	5
UniProt:P01135 TGFA	5	TGFA(24-98) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817) TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476) TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841) TGFA(24-98) [extracellular region] (R-HSA-9624183) TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840)	0.779	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [nucleoplasm] (R-HSA-5082401)	0.778	7
UniProt:P42224 STAT1	7	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202)	0.774	7
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.773	4
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.773	5
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.772	5
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.772	7
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.772	6
UniProt:P27986 PIK3R1	15	PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 K459del [plasma membrane] (R-HSA-2399554)	0.762	6
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.76	7
UniProt:P0DP24 CALM			0.756	4
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.749	5
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006)	0.745	7
UniProt:Q71U36 TUBA1A	9	TUBA1A unfolded [cytosol] (R-HSA-392767) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A [cytosol] (R-HSA-191689) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428)	0.745	4
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.745	5
UniProt:P38646 HSPA9	6	HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [cytosol] (R-HSA-5251993)	0.745	5
UniProt:P26447 S10A4			0.743	6
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.743	6
UniProt:Q92625 ANS1A			0.737	6
UniProt:Q92870 APBB2			0.737	7
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.737	4
UniProt:P12830 CDH1	10	Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-882) [plasma membrane] (R-HSA-198003) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(751-882) [plasma membrane] (R-HSA-3827962)	0.735	4
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.729	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.721	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	11
UniProt:Q13387 JIP2			0.692	5
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.692	4
UniProt:P23467 PTPRB	3	PTPRB [tertiary granule membrane] (R-HSA-6801032) PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [plasma membrane] (R-HSA-437247)	0.692	3
UniProt:P43403 ZAP70	3	p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252) ZAP70 [cytosol] (R-HSA-202397) p-Y493-ZAP70 [cytosol] (R-HSA-202368)	0.692	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.692	9
UniProt:O00459 PIK3R2	2	K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) PIK3R2 [cytosol] (R-HSA-74791)	0.692	4
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.692	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.692	3
UniProt:Q13239 SLA	1	SLA [cytosol] (R-HSA-9706158)	0.692	3
UniProt:P16234 PDGFRA	20	PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) p-11Y PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673609) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA D843_846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA Y849C [plasma membrane] (R-HSA-9671974) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027)	0.683	4
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.683	4
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.683	5
UniProt:Q99962 SH3GL2	4	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495)	0.681	4
UniProt:O75368 SH3L1			0.681	3
UniProt:O60603 TLR2	3	TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [plasma membrane] (R-HSA-167992)	0.681	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.681	4
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.681	3
UniProt:Q9UKV8 AGO2	2	EIF2C2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.679	11
UniProt:Q9UQC2 GAB2	5	p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-Y643-GAB2 [cytosol] (R-HSA-9677149) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574)	0.669	3
UniProt:P34932 HSPA4	2	HSPA4 [nucleoplasm] (R-HSA-5251998) HSPA4 [cytosol] (R-HSA-5251946)	0.668	3
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747) CFL1 [cytosol] (R-HSA-350751)	0.668	3
UniProt:Q13480 GAB1	4	p-Y-GAB1 [cytosol] (R-HSA-8855306) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344)	0.667	4
UniProt:Q09666 AHNK			0.667	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) p-T156 AP2M1 [cytosol] (R-HSA-8856805) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [plasma membrane] (R-HSA-167585)	0.667	5
UniProt:P06493 CDK1	10	p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075)	0.667	3
UniProt:P51636 CAV2	2	CAV2 [plasma membrane] (R-HSA-9021035) CAV2 [Golgi membrane] (R-HSA-9021032)	0.667	3
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.667	3
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.653	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.644	13
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.643	5
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.635	3
UniProt:P04150 NR3C1	3	NR3C1 [nucleoplasm] (R-HSA-879837) NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106)	0.635	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.635	3
UniProt:Q9Y2H9 MAST1			0.635	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.635	3
UniProt:P42229 STAT5A	6	STAT5A [cytosol] (R-HSA-380747) p-Y649-STAT5A [cytosol] (R-HSA-8980151) STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) p-STAT5A [nucleoplasm] (R-HSA-8982836)	0.635	4
UniProt:P17252 PRKCA	8	p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) PRKCA [plasma membrane] (R-HSA-156469) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.635	3
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.635	3
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116)	0.635	3
UniProt:Q6S5L8 SHC4			0.635	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.635	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.635	3
UniProt:Q9P0L0 VAPA	4	VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.635	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.635	3
UniProt:Q02952 AKAP12	1	AKAP12 [plasma membrane] (R-HSA-9715082)	0.635	3
UniProt:Q9BRG2 SH23A			0.635	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.635	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [cytosol] (R-HSA-66370)	0.635	4
UniProt:Q14247 CTTN	2	p-S113-CTTN [cytosol] (R-HSA-442842) CTTN [cytosol] (R-HSA-201894)	0.635	4
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.635	3
UniProt:O43561 LAT	3	p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.635	3
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.635	3
UniProt:Q14457 BECN1	3	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.628	7
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926) SH3KBP1 [plasma membrane] (R-HSA-182955)	0.623	3
UniProt:Q12852 M3K12			0.621	3
UniProt:Q6UW88 EPGN	2	EPGN(23-154) [extracellular region] (R-HSA-9624187) EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628815)	0.618	3
UniProt:O14944 EREG	2	EREG(60-108) [extracellular region] (R-HSA-1233233) EREG(60-108) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628816)	0.618	3
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.615	4
UniProt:P04792 HSPB1	3	p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563)	0.615	3
UniProt:Q99075 HBEGF	9	HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782) HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819) HBEGF(63-148) [extracellular region] (R-HSA-1233234) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(20-208) [plasma membrane] (R-HSA-5334771) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776)	0.609	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.599	4
UniProt:Q86VI4 LAP4B			0.599	10
UniProt:Q8TF42 UBS3B			0.597	6
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	6
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.592	2
UniProt:P14174 MIF	3	MIF [ficolin-1-rich granule lumen] (R-HSA-6803289) MIF [extracellular region] (R-HSA-212594) MIF [secretory granule lumen] (R-HSA-6803282)	0.591	3
UniProt:P29353-7 SHC1			0.581	4
UniProt:O14965 AURKA	6	PolyUb-AURKA [cytosol] (R-HSA-8854040) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) AURKA [nucleoplasm] (R-HSA-4655443)	0.581	4
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.576	8
UniProt:P23470 PTPRG			0.573	3
UniProt:P07992 ERCC1	2	Ub-ERCC1 [nucleoplasm] (R-HSA-5696473) ERCC1 [nucleoplasm] (R-HSA-54427)	0.571	21
UniProt:Q92622 RUBIC			0.564	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.564	2
UniProt:P62994 Grb2	3	Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686) Grb2 [cytosol] (R-RNO-55929)	0.564	5
UniProt:Q8IZV2 CKLF8			0.556	3
UniProt:O75674 TM1L1			0.556	6
UniProt:Q99952 PTPN18	2	PTPN18 [nucleoplasm] (R-HSA-9008900) PTPN18 [cytosol] (R-HSA-8864101)	0.553	2
UniProt:Q02246 CNTN2	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.553	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181)	0.553	2
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.553	2
UniProt:P05107 ITGB2	4	ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [plasma membrane] (R-HSA-198010)	0.553	2
UniProt:P40925 MDH1	1	MDH1 [cytosol] (R-HSA-198471)	0.553	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.553	2
UniProt:P37840 SNCA	4	SNCA [cytosol] (R-HSA-5658500) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) Ub-SNCA [cytosol] (R-HSA-5660754)	0.553	2
UniProt:Q9H299 SH3L3			0.553	2
UniProt:Q8N111 CEND			0.553	2
UniProt:Q59GR8 Q59GR8			0.553	2
UniProt:Q16620 NTRK2	6	p-5Y,S479-NTRK2 [plasma membrane] (R-HSA-9032864) NTRK2 [Golgi membrane] (R-HSA-3008801) p-5Y-NTRK2 [plasma membrane] (R-HSA-9026475) p-5Y-NTRK2 [Golgi membrane] (R-HSA-3008809) NTRK2 [plasma membrane] (R-HSA-6798236) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044)	0.553	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [cytosol] (R-HSA-380285)	0.553	2
UniProt:Q59G22 Q59G22			0.553	2
UniProt:P16930 FAH	1	FAH [cytosol] (R-HSA-71174)	0.553	2
UniProt:Q99704 DOK1	2	p-Y362-DOK1 [cytosol] (R-HSA-8848784) DOK1 [cytosol] (R-HSA-74763)	0.553	2
UniProt:Q13491 GPM6B			0.553	2
UniProt:A4FU49 SH321			0.553	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.553	2
UniProt:O95433 AHSA1			0.553	2
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.553	2
UniProt:P30307 CDC25C	8	p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668) CDC25C [nucleoplasm] (R-HSA-69741) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S216-CDC25C [cytosol] (R-HSA-75003) CDC25C [cytosol] (R-HSA-157879) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968)	0.553	2
UniProt:Q7L273 KCTD9			0.553	2
UniProt:Q4KWH8 PLCH1	1	PLCH1 [plasma membrane] (R-HSA-2023859)	0.553	2
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.553	2
UniProt:O15511 ARPC5	4	ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [cytosol] (R-HSA-200806) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [secretory granule lumen] (R-HSA-6801071)	0.553	2
UniProt:P55036 PSMD4	2	PSMD4 [cytosol] (R-HSA-68800) PSMD4 [nucleoplasm] (R-HSA-174330)	0.553	2
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.553	2
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.553	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.553	2
UniProt:Q9NZM3 ITSN2	1	ITSN2 [cytosol] (R-HSA-8862264)	0.553	2
UniProt:P31321 PRKAR1B	2	PRKAR1B [ciliary base] (R-HSA-5610409) PRKAR1B [cytosol] (R-HSA-57838)	0.553	2
UniProt:P19438 TNFRSF1A	3	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(22-455) [plasma membrane] (R-HSA-66344) TNFRSF1A [plasma membrane] (R-HSA-5675738)	0.553	2
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-p-6Y ALK(1106-1620) fusion [cytosol] (R-HSA-9710850) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839)	0.553	2
UniProt:Q15750 TAB1	2	TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.553	2
UniProt:P06132 UROD	1	UROD [cytosol] (R-HSA-189427)	0.553	2
UniProt:P04075 ALDOA	6	ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [cytosol] (R-HSA-71492) ALDOA [extracellular region] (R-HSA-349735) ALDOA [secretory granule lumen] (R-HSA-6801469)	0.553	2
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) N-WASP [cytosol] (R-HSA-201873) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.553	2
UniProt:Q13905 RAPGEF1	3	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [cytosol] (R-HSA-3008672) RAPGEF1 [endosome] (R-HSA-3008667)	0.553	2
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.553	2
UniProt:Q8TDI0 CHD5			0.553	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [cytosol] (R-HSA-5618108) FKBP4 [nucleoplasm] (R-HSA-5324621)	0.553	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN(28-403) [cytosol] (R-HSA-201618) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272)	0.553	2
UniProt:Q8N2Y8 RUSC2			0.553	2
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.553	2
UniProt:Q53GZ6 Q53GZ6			0.553	2
UniProt:P17600 SYN1	2	SYN1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-380577) SYN1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659624)	0.553	2
UniProt:P31939 ATIC	5	ATIC(1-229)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9710847) ATIC [cytosol] (R-HSA-62506) ATIC(1-230)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710832) ATIC(1-229)-ALK(1058-1620) fusion [cytosol] (R-HSA-9710829) ATIC(1-230)-p-7Y ALK(1059-1620) fusion [cytosol] (R-HSA-9710833)	0.553	2
UniProt:Q08881 ITK	3	ITK [cytosol] (R-HSA-202319) p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)	0.553	2
UniProt:P54368 OAZ1	1	OAZ1 [cytosol] (R-HSA-350587)	0.553	2
UniProt:Q9UPY6 WASF3	3	WASF3 [cytosol] (R-HSA-200975) p-Y151,S,T-WASF3 [cytosol] (R-HSA-5672385) p-Y151-WASF3 [cytosol] (R-HSA-2029006)	0.553	2
UniProt:P20336 RAB3A	9	GGC-RAB3A [cytosol] (R-HSA-8870429) RAB3A [secretory granule membrane] (R-HSA-6804968) RAB3A [plasma membrane] (R-HSA-210461) RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365) RAB3A [cytosol] (R-HSA-8870410) RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743) RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512) RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466) GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)	0.553	2
UniProt:P17174 GOT1	1	PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)	0.553	2
UniProt:Q9NNZ3 DNJC4			0.553	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990) SNX9 [cytosol] (R-HSA-8867737)	0.553	2
UniProt:Q14050 COL9A3	20	3x4Hyp-5Hyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179200) COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179195) COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179193) 3Hyp-4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470384) GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179194) 3x4Hyp-3Hyp-5Hyl-COL9A3(?-684) [extracellular region] (R-HSA-2470431) 3x4Hyp-5Hyl-COL9A3(26-?) [extracellular region] (R-HSA-2470398) 3x4Hyp-3Hyp-GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179201) 3Hyp-4Hyp-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179192) 3x4Hyp-5Hyl-COL9A3(?-684) [extracellular region] (R-HSA-2470450) 3x4Hyp-3Hyp-5Hyl-COL9A3(26-?) [extracellular region] (R-HSA-2470397) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179210) 3x4Hyp-3Hyp-5Hyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179196) 3x4Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179209) 3x4Hyp-GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470426) GlcGalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470430) COL9A3(?-684) [extracellular region] (R-HSA-2470427) GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179198) 3x4Hyp-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179208) 3x4Hyp-GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179203)	0.553	2
UniProt:O94992 HEXI1			0.553	2
UniProt:Q9Y3A3 PHOCN			0.553	2
UniProt:Q96AD5 PNPLA2	3	PNPLA2 [endoplasmic reticulum membrane] (R-HSA-1498814) PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956776) p-PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956923)	0.553	2
UniProt:P14923 JUP	6	JUP [cornified envelope] (R-HSA-8847739) JUP [extracellular region] (R-HSA-6806309) JUP [plasma membrane] (R-HSA-437260) JUP [specific granule lumen] (R-HSA-6799534) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cytosol] (R-HSA-201598)	0.553	2
UniProt:O94875 SRBS2			0.553	2
UniProt:Q15819 UBE2V2	2	UBE2V2 [nucleoplasm] (R-HSA-5682543) UBE2V2 [cytosol] (R-HSA-947624)	0.553	2
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.553	2
UniProt:Q6UWJ1 TMCO3			0.553	2
UniProt:Q99784 NOE1			0.553	2
UniProt:Q92918 M4K1			0.553	2
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.553	2
UniProt:P49798 RGS4	1	RGS4 [plasma membrane] (R-HSA-921135)	0.553	2
UniProt:O75095 MEGF6			0.553	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.553	2
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.553	2
UniProt:Q8N5H7 SH2D3			0.553	2
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.553	2
UniProt:Q02297 NRG1	1	NRG1 [extracellular region] (R-HSA-1227951)	0.553	2
UniProt:Q9H6Q3 SLA2	1	SLA2 [cytosol] (R-HSA-9706161)	0.553	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.553	2
UniProt:Q92733 PRCC	1	PRCC [nucleoplasm] (R-HSA-8867896)	0.553	2
UniProt:P15498 VAV1	5	p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087) VAV1 [cytosol] (R-HSA-195066) VAV1 [plasma membrane] (R-HSA-1045153)	0.553	2
UniProt:Q59EJ3 Q59EJ3			0.553	2
UniProt:Q07954 LRP1	3	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-2424272)	0.553	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.553	2
UniProt:P43243 MATR3			0.553	2
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.553	2
UniProt:P49908 SELENOP	2	SEPP1 [extracellular region] (R-HSA-8848887) SEPP1 [platelet dense granule lumen] (R-HSA-8848897)	0.553	2
UniProt:Q8TDB4 HUMMR			0.553	2
UniProt:P32121 ARRB2	2	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000)	0.553	2
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.553	2
UniProt:Q9Y237 PIN4			0.553	2
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.553	2
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.553	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.553	2
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [plasma membrane] (R-HSA-3928409) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622)	0.553	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.553	2
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) MAPK8 [cytosol] (R-HSA-168141)	0.553	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.553	2
UniProt:P11309 PIM1	1	PIM1 [nucleoplasm] (R-HSA-3215094)	0.553	2
UniProt:P21291 CSRP1	1	CSRP1 [nucleoplasm] (R-HSA-5660398)	0.553	2
UniProt:P42685 FRK	4	FRK [specific granule lumen] (R-HSA-6801037) FRK [azurophil granule lumen] (R-HSA-6799142) FRK [extracellular region] (R-HSA-6806235) p-Y387-FRK [cytosol] (R-HSA-8847965)	0.553	2
UniProt:P60880 SNAP25	7	SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25 [plasma membrane] (R-HSA-2029017) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25(199-206) [cytosol] (R-HSA-5244501)	0.553	2
UniProt:P52630 STAT2	4	p-Y-STAT2 [cytosol] (R-HSA-8987235) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [cytosol] (R-HSA-909683)	0.553	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG E391* [cytosol] (R-HSA-5262924) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG R173G [cytosol] (R-HSA-5262966)	0.553	2
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628)	0.553	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.553	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.553	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.553	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.553	2
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.553	2
UniProt:P49407 ARRB1	5	ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.553	2
UniProt:P31749 AKT1	13	AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252)	0.553	2
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.553	2
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [cytosol] (R-HSA-197938)	0.547	2
UniProt:P10586 PTPRF	1	PTPRF [plasma membrane] (R-HSA-6786486)	0.547	2
UniProt:P23468 PTPRD	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.547	2
UniProt:Q14956-1 GPNMB			0.544	2
UniProt:P07948-1 LYN			0.544	2
UniProt:Q38SD2 LRRK1			0.544	2
UniProt:P17936 IGFBP3	15	IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963)	0.539	3
UniProt:P0DTC2 S	16	high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9696917) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi