Reactome | EGFRvIII [plasma membrane]

EGFRvIII [plasma membrane]

Stable Identifier

R-HSA-1214162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EGFR V30_R297delinsG mutant, Epidermal Growth Factor Receptor V30_R297delinsG mutant, EGFR Val30_Arg297delinsGly mutant

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General

EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRvIII, is found in ~25% high-grade glioblastomas and can also be found in squamous cell carcinoma of the lung. EGFRvIII lacks the ligand biding domain and is constitutively active.

External Reference Information

External Reference

UniProt:P00533 EGFR

Gene Names

EGFR, ERBB, ERBB1, HER1

Chain

signal peptide:1-24, chain:25-1210

Reference Genes

BioGPS Gene:1956 EGFR

COSMIC (genes):EGFR EGFR

CTD Gene:1956 EGFR

dbSNP Gene:1956 EGFR

ENSEMBL:ENSG00000146648 EGFR

HGNC:3236 EGFR

KEGG Gene (Homo sapiens):1956 EGFR

Monarch:1956 EGFR

NCBI Gene:1956 EGFR

OMIM:131550 EGFR

UCSC:P00533 EGFR

Reference Transcript

Other Identifiers

0000840253

0002940025

0005900148

0006350504

11725102_at

11725103_s_at

11725104_a_at

11733760_a_at

11738815_at

11742247_a_at

11751983_a_at

1537_at

1565483_at

1565484_x_at

17046135

1956

201983_s_at

201984_s_at

210984_x_at

211550_at

211607_x_at

224999_at

3002641

3002642

3002729

3002731

3002733

3002738

3002741

3002743

3002747

3002749

3002750

3002751

3002753

3002757

3002760

3002761

3002763

3002767

3002769

3002770

3002771

3002775

3002776

3002778

3002779

3002786

3002798

3002800

3002801

3002802

3002806

3002807

3002808

3002811

3002812

3002813

3002814

3002815

3002816

3002817

3002818

3002819

3002820

3002821

3002822

3002823

3002824

3002825

37327_at

48285_at

65700_at

8132860

A_14_P106592

A_23_P215790

A_33_P3351944

A_33_P3351955

GE59632

GE85333

GO:0000003

GO:0000139

GO:0000165

GO:0000166

GO:0000186

GO:0000278

GO:0000902

GO:0001503

GO:0001618

GO:0001889

GO:0001892

GO:0001934

GO:0001942

GO:0003013

GO:0003674

GO:0003677

GO:0003682

GO:0003690

GO:0004672

GO:0004709

GO:0004713

GO:0004714

GO:0004888

GO:0005006

GO:0005102

GO:0005178

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005887

GO:0005925

GO:0006259

GO:0006357

GO:0006412

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0006970

GO:0006979

GO:0007049

GO:0007155

GO:0007165

GO:0007166

GO:0007169

GO:0007173

GO:0007202

GO:0007267

GO:0007275

GO:0007435

GO:0007494

GO:0007611

GO:0007623

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008544

GO:0009056

GO:0009058

GO:0009790

GO:0009925

GO:0009986

GO:0010008

GO:0010750

GO:0010960

GO:0014066

GO:0014070

GO:0015031

GO:0016020

GO:0016021

GO:0016032

GO:0016101

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0019903

GO:0021795

GO:0030054

GO:0030139

GO:0030154

GO:0030234

GO:0030235

GO:0030307

GO:0030324

GO:0030335

GO:0030665

GO:0031410

GO:0031625

GO:0031901

GO:0031965

GO:0032355

GO:0032930

GO:0032991

GO:0033138

GO:0033590

GO:0033594

GO:0033674

GO:0033993

GO:0034614

GO:0034641

GO:0035556

GO:0035690

GO:0038083

GO:0038128

GO:0040007

GO:0040011

GO:0042059

GO:0042060

GO:0042127

GO:0042177

GO:0042327

GO:0042592

GO:0042698

GO:0042743

GO:0042802

GO:0043006

GO:0043066

GO:0043167

GO:0043226

GO:0043235

GO:0043406

GO:0043586

GO:0044403

GO:0044877

GO:0045121

GO:0045202

GO:0045296

GO:0045737

GO:0045739

GO:0045740

GO:0045746

GO:0045780

GO:0045893

GO:0045907

GO:0045930

GO:0045944

GO:0046328

GO:0046718

GO:0046777

GO:0048143

GO:0048146

GO:0048408

GO:0048471

GO:0048546

GO:0048661

GO:0048812

GO:0048856

GO:0048870

GO:0050679

GO:0050729

GO:0050730

GO:0050877

GO:0050999

GO:0051015

GO:0051117

GO:0051186

GO:0051205

GO:0051592

GO:0051897

GO:0051968

GO:0060571

GO:0061024

GO:0061029

GO:0070141

GO:0070372

GO:0070374

GO:0070435

GO:0071230

GO:0071260

GO:0071276

GO:0071363

GO:0071364

GO:0071392

GO:0071549

GO:0090263

GO:0097421

GO:0097489

GO:0097755

GO:0098609

GO:1900020

GO:1900087

GO:1901185

GO:1901224

GO:1902722

GO:1903078

GO:1903800

GO:1905208

GO:2000145

Hs.279898.0.S1_3p_at

Hs.77432.0.S1_3p_a_at

Hs2.367845.1.S1_3p_at

Hs2.367845.1.S1_3p_x_at

ILMN_1696521

ILMN_1728858

ILMN_1755535

ILMN_1798975

ILMN_1905285

PH_hs_0004462

PH_hs_0014421

TC07000328.hg

TC07002321.hg

TC07002322.hg

X00588_at

g12002211_3p_at

g1628549_3p_s_at

g4885198_3p_a_at

Participant Of

input

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37.

hasComponent

EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Other forms of this molecule

p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]

p-5Y-EGFRvIII [plasma membrane]

p-6Y-EGFR E746_A750del;T790M [plasma membrane]

p-6Y-EGFR L858R;T790M [plasma membrane]

p-6Y-EGFR M766_A767insASV [plasma membrane]

p-6Y-EGFR D770_N771insNPH [plasma membrane]

p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]

p-6Y-EGFR D770_N771insNPG [plasma membrane]

p-6Y-EGFR E746_A750del [plasma membrane]

p-6Y-EGFR L858R [plasma membrane]

p-6Y-EGFR G719S [plasma membrane]

p-6Y-EGFR L747_P753delinsS [plasma membrane]

p-6Y-EGFR L747_A750delinsP [plasma membrane]

p-6Y-EGFR L747_T751del [plasma membrane]

p-6Y-EGFR L747_S752del [plasma membrane]

p-6Y-EGFR L747_T751delinsP [plasma membrane]

p-6Y-EGFR E746_T751delinsA [plasma membrane]

p-6Y-EGFR E746_S752delinsV [plasma membrane]

p-6Y-EGFR L861Q [plasma membrane]

p-6Y-EGFR A289V [plasma membrane]

p-6Y-EGFR T263P [plasma membrane]

p-6Y-EGFR G598V [plasma membrane]

p-6Y-EGFR R108K [plasma membrane]

p-6Y-EGFR A289T [plasma membrane]

p-6Y-EGFR G719C [plasma membrane]

p-6Y-EGFR A289D [plasma membrane]

p-6Y-EGFR G719A [plasma membrane]

EGFR L858R;T790M [plasma membrane]

EGFR E746_A750del;T790M [plasma membrane]

EGFR D770_N771insNPG [plasma membrane]

EGFR V738_K739insKIPVAI [plasma membrane]

EGFR M766_A767insASV [plasma membrane]

EGFR D770_N771insNPH [plasma membrane]

EGFR L858R [plasma membrane]

EGFR G719S [plasma membrane]

EGFR E746_A750del [plasma membrane]

EGFR L747_P753delinsS [plasma membrane]

EGFR A289V [plasma membrane]

EGFR L747_T751delinsP [plasma membrane]

EGFR L747_T751del [plasma membrane]

EGFR A289D [plasma membrane]

EGFR L861Q [plasma membrane]

EGFR R108K [plasma membrane]

EGFR L747_A750delinsP [plasma membrane]

EGFR E746_T751delinsA [plasma membrane]

EGFR G719A [plasma membrane]

EGFR A289T [plasma membrane]

EGFR E746_S752delinsV [plasma membrane]

EGFR G719C [plasma membrane]

EGFR T263P [plasma membrane]

EGFR G598V [plasma membrane]

EGFR L747_S752del [plasma membrane]

EGFR [endosome membrane]

p-4Y-EGFR [plasma membrane]

p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]

p-Y1086,Y1101-EGFR [plasma membrane]

EGFR [plasma membrane]

p-6Y-EGFR [plasma membrane]

Modified Residues

Name

Deletion of residues 30 to 296

Name

L-arginine 297 replaced with glycine

Coordinate

297

PsiMod

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

Disease

Name	Identifier	Synonyms
brain glioma	0060108
cancer	162	malignant tumor, malignant neoplasm, primary cancer
glioblastoma multiforme	3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
lung squamous cell carcinoma	3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
astrocytoma	3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma

Cross References

RefSeq

NP_958440.1, NP_958439.1, NP_958441.1, NP_005219.2

ZINC - World Drugs

EGFR_HUMAN

OpenTargets

ENSG00000146648

ZINC - FDA approved

EGFR_HUMAN

ZINC - Substances

EGFR_HUMAN

ZINC target

P00533

ZINC - Biogenic

EGFR_HUMAN

PRO

P00533

PDB

2RF9, 4I23, 4RJ4, 5CAU, 6JRJ, 2ITU, 4UIP, 5CNO, 2EXQ, 5EM5, 6ARU, 3UG2, 4I1Z, 5GMP, 5HCZ, 4ZAU, 5J9Z, 4KRP, 5CAN, 6V6K, 6S8A, 5UG9, 5HIC, 4RJ7, 2RFE, 2ITN, 5Y25, 1MOX, 5WB8, 5YU9, 6JX4, 4ZJV, 5X2C, 4KRL, 3G5Y, 5XGN, 5HG8, 2EXP, 5CAQ, 4I21, 3C09, 3GT8, 2ITZ, 3W2Q, 5C8K, 5FEQ, 1Z9I, 6V66, 4TKS, 4R5S, 3PFV, 3GOP, 2ITY, 4RIW, 4I22, 2GS2, 2J6M, 4G5P, 5CAS, 5XDK, 5D41, 5UGB, 3VRR, 5FEE, 2ITT, 3LZB, 5CAP, 6S9C, 5EM7, 3G5V, 3QWQ, 4JQ7, 5SX5, 6S89, 2GS6, 5UG8, 2RFD, 4RJ6, 6P8Q, 3B2U, 4KRO, 4ZSE, 5WB7, 6JX0, 3BEL, 5UWD, 5HG7, 5JEB, 6DUK, 6P1L, 6V5P, 1IVO, 4LRM, 2ITQ, 5C8N, 5HCY, 5GTZ, 2J5F, 4UV7, 3NJP, 3POZ, 6VH4, 5X27, 5CNN, 3B2V, 3W2P, 4I20, 5CZH, 5EDQ, 2ITX, 1DNQ, 6V6O, 5UGA, 3VJO, 6JZ0, 2JIU, 2M20, 2ITP, 4RIY, 5ZTO, 4G5J, 1DNR, 3W2S, 1NQL, 5X2K, 5EM6, 3UG1, 4RJ8, 5HIB, 5ZWJ, 4R3R, 4LQM, 3OB2, 4WD5, 5CAL, 6VHP, 5X2A, 4JR3, 5XGM, 2M0B, 3W33, 2ITO, 5UGC, 5GTY, 5HCX, 2GS7, 6S9B, 5HG9, 5X26, 5J9Y, 2JIT, 2JIV, 4WRG, 5EDP, 5EM8, 2RGP, 3P0Y, 2ITW, 5Y9T, 2N5S, 4LL0, 5GNK, 6JRK, 4JRV, 4RJ5, 5FED, 4RIX, 3VRP, 1M14, 3W2R, 5LV6, 2EB2, 5SX4, 5EDR, 2KS1, 5XDL, 6B3S, 5CAO, 1XKK, 6S9D, 4I24, 6JXT, 4R3P, 4KRM, 6P1D, 5HG5, 6V5N, 3OP0, 6D8E, 3W32, 4WKQ, 6VHN, 5X2F, 1M17, 2EB3, 3BUO, 4JQ8, 2ITV, 4LI5, 5CZI, 5C8M, 3IKA, 1YY9, 5U8L, 6JRX, 3VJN, 5X28, 4HJO, 2J5E, 5CAV, 3W2O, 5XWD, 6JWL

ZINC - Investigational

EGFR_HUMAN

ZINC - Metabolites

EGFR_HUMAN

COSMIC

21351

GeneCards

P00533

HPA

ENSG00000146648-EGFR

Ensembl

ENSP00000413843, ENST00000420316, ENST00000344576, ENSG00000146648, ENST00000342916, ENSP00000345973, ENSP00000342376, ENSP00000275493, ENST00000275493

Orphanet

15917

ZINC - Predictions - Purchasable

EGFR_HUMAN

HMDB Protein

HMDBP01456

Interactors (283)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.981	29
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.981	56
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.973	41
UniProt:P01133 EGF	5	Pro-EGF [extracellular region] (R-HSA-54209) EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086) Pro-EGF [platelet alpha granule lumen] (R-HSA-139875) Pro-EGF [plasma membrane] (R-HSA-179888) EGF [extracellular region] (R-HSA-179863)	0.973	29
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.964	26
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.96	25
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.924	15
UniProt:P21860 ERBB3			0.916	13
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.9	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.89	10
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.864	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.854	7
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.85	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.833	9
UniProt:Q9UJM3 ERRFI			0.826	13
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.82	7
UniProt:P15941 MUC1	19	Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.819	6
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.813	7
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.811	10
UniProt:P08107 HSP71			0.809	6
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.809	12
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.807	5
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.803	7
UniProt:P16885 PLCG2	10	PLCG2 [cytosol] (R-HSA-984806) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.802	6
UniProt:P20417	1	Ptpn1 [cytosol] (R-RNO-210625)	0.802	11
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.8	8
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.785	7
UniProt:P10599 TXN	4	TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.785	5
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.779	6
UniProt:P01135 TGFA	5	TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476) TGFA(24-98) [extracellular region] (R-HSA-9624183) TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840) TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841) TGFA(24-98) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817)	0.779	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.778	7
UniProt:P42224 STAT1	7	p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624)	0.774	7
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.773	7
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.773	4
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.773	5
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.772	7
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.772	6
UniProt:P04083 ANXA1	2	ANXA1 [extracellular region] (R-HSA-444539) ANXA1 [cytosol] (R-HSA-5263630)	0.772	5
UniProt:P46109 CRKL	2	p-CRKL [cytosol] (R-HSA-9024730) CRKL [cytosol] (R-HSA-354384)	0.765	5
UniProt:P62158 CALM			0.756	4
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.756	4
UniProt:Q71U36 TUBA1A	9	Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408)	0.745	4
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.745	5
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.745	7
UniProt:P38646 HSPA9	6	HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.745	5
UniProt:P26447 S10A4			0.743	6
UniProt:Q96JA1 LRIG1	2	LRIG1 [plasma membrane] (R-HSA-197745) Ub-LRIG1 [plasma membrane] (R-HSA-8875434)	0.743	6
UniProt:Q92625 ANS1A			0.737	6
UniProt:Q92870 APBB2			0.737	7
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.737	4
UniProt:Q13322 GRB10	2	GRB10 [cytosol] (R-HSA-110009) p-Y GRB10 [cytosol] (R-HSA-9706168)	0.729	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.721	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	11
UniProt:Q13387 JIP2			0.692	5
UniProt:P23467 PTPRB	3	PTPRB [plasma membrane] (R-HSA-437247) PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [tertiary granule membrane] (R-HSA-6801032)	0.692	3
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.692	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.692	4
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.692	9
UniProt:P43403 ZAP70	3	p-Y493-ZAP70 [cytosol] (R-HSA-202368) ZAP70 [cytosol] (R-HSA-202397) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)	0.692	3
UniProt:P51451 BLK	2	BLK [cytosol] (R-HSA-983580) MyrG2-BLK [plasma membrane] (R-HSA-9606871)	0.692	3
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.692	3
UniProt:Q13239 SLA	1	SLA [cytosol] (R-HSA-9706158)	0.692	3
UniProt:Q14318 FKBP8	2	FKBP8 [mitochondrial outer membrane] (R-HSA-5696928) PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001)	0.683	4
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.683	5
UniProt:P16234 PDGFRA	47	PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y PDGFRA del375-455 [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA D843_846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974) PDGFRA D843_844del [plasma membrane] (R-HSA-9671559) PDGFRA D846V [plasma membrane] (R-HSA-9674306) PDGFRA D842L [plasma membrane] (R-HSA-9674303) PDGFRA V561D [plasma membrane] (R-HSA-9671557) PDGFRA V561A [plasma membrane] (R-HSA-9671968) PDGFRA V536E [plasma membrane] (R-HSA-9671964) PDGFRA V536M [plasma membrane] (R-HSA-9676950) p-11Y PDGFRA D842V [plasma membrane] (R-HSA-9671979) p-11Y PDGFRA D846Y [plasma membrane] (R-HSA-9672009) p-11Y PDGFRA D842del [plasma membrane] (R-HSA-9671998) p-11Y PDGFRA D843_844del [plasma membrane] (R-HSA-9672001) p-11Y PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671991) p-11Y PDGFRA D843_846del [plasma membrane] (R-HSA-9672007) p-11Y PDGFRA D842Y [plasma membrane] (R-HSA-9671982) p-11Y PDGFRA D842_H845del [plasma membrane] (R-HSA-9671989) p-11Y PDGFRA D842_D846del [plasma membrane] (R-HSA-9671986) p-10Y PDGFRA Y849C [plasma membrane] (R-HSA-9671977) p-11Y PDGFRA D843_845del [plasma membrane] (R-HSA-9672003) p-11Y PDGFRA N848K [plasma membrane] (R-HSA-9672015) p-11Y PDGFRA D842L dimer [plasma membrane] (R-HSA-9674313) p-11Y PDGFRA D846V [plasma membrane] (R-HSA-9674316) p-11Y PDGFRA V536E [plasma membrane] (R-HSA-9672018) p-11Y PDGFRA V536M [plasma membrane] (R-HSA-9676956) p-11Y PDGFRA V561D [plasma membrane] (R-HSA-9672025) p-11Y PDGFRA V561A [plasma membrane] (R-HSA-9672021) PDGFRA [plasma membrane] (R-HSA-186794) p-11Y-PDGFRA [plasma membrane] (R-HSA-186806)	0.683	4
UniProt:O75368 SH3L1			0.681	3
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.681	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.681	4
UniProt:O60603 TLR2	3	TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [plasma membrane] (R-HSA-167992)	0.681	3
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.681	4
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.681	3
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) EIF2C2 [nucleoplasm] (R-HSA-5578701)	0.679	11
UniProt:Q9UQC2 GAB2	4	p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-Y-GAB2 [cytosol] (R-HSA-912529) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574)	0.669	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.669	3
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.669	4
UniProt:P34932 HSPA4	2	HSPA4 [nucleoplasm] (R-HSA-5251998) HSPA4 [cytosol] (R-HSA-5251946)	0.668	3
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [cytosol] (R-HSA-350751) CFL1 [extracellular region] (R-HSA-350747)	0.668	3
UniProt:Q09666 AHNK			0.667	4
UniProt:P51636 CAV2	2	CAV2 [Golgi membrane] (R-HSA-9021032) CAV2 [plasma membrane] (R-HSA-9021035)	0.667	3
UniProt:Q13480 GAB1	4	p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.667	4
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.667	3
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)	0.667	3
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [lysosomal membrane] (R-HSA-196144) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.667	5
UniProt:Q8NBJ4 GOLM1	2	GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710) p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938)	0.644	13
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.643	5
UniProt:P60520 GABARAPL2	3	GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.635	3
UniProt:P04150 NR3C1	3	NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [nucleoplasm] (R-HSA-879837)	0.635	3
UniProt:Q9Y2H9 MAST1			0.635	3
UniProt:Q12929 EPS8			0.635	3
UniProt:P42229 STAT5A	5	p-Y649-STAT5A [cytosol] (R-HSA-8980151) p-STAT5A [nucleoplasm] (R-HSA-8982836) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [cytosol] (R-HSA-507936)	0.635	4
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.635	3
UniProt:Q6S5L8 SHC4			0.635	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.635	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.635	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.635	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920) VAPA [plasma membrane] (R-HSA-6806269) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.635	3
UniProt:Q14247 CTTN	2	p-S113-CTTN [cytosol] (R-HSA-442842) CTTN [cytosol] (R-HSA-201894)	0.635	4
UniProt:Q02952 AKA12			0.635	3
UniProt:Q9BRG2 SH23A			0.635	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.635	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.635	3
UniProt:P09769 FGR	3	FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116) FGR [extracellular region] (R-HSA-6806524)	0.635	3
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.635	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.635	3
UniProt:O43561 LAT	3	LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.635	3
UniProt:P17252 PRKCA	8	p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [cytosol] (R-HSA-58196) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) PRKCA [plasma membrane] (R-HSA-156469) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.635	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.635	4
UniProt:Q14457 BECN1	3	BECN1 [cytosol] (R-HSA-1632841) K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391)	0.628	7
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) SH3KBP1 [plasma membrane] (R-HSA-182955) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.623	3
UniProt:Q12852 M3K12			0.621	3
UniProt:Q6UW88 EPGN	2	EPGN(23-154) [extracellular region] (R-HSA-9624187) EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628815)	0.618	3
UniProt:O14944 EREG	2	EREG(60-108) [extracellular region] (R-HSA-1233233) EREG(60-108) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628816)	0.618	3
UniProt:Q99075 HBEGF	9	HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782) HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776) HBEGF(20-208) [plasma membrane] (R-HSA-5334771) HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(63-148) [extracellular region] (R-HSA-1233234)	0.609	3
UniProt:O14965 AURKA	6	p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.602	4
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.599	4
UniProt:Q86VI4 LAP4B			0.599	10
UniProt:P07992 ERCC1	2	ERCC1 [nucleoplasm] (R-HSA-54427) Ub-ERCC1 [nucleoplasm] (R-HSA-5696473)	0.599	21
UniProt:Q8TF42 UBS3B			0.597	6
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	6
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.592	2
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289) MIF [extracellular region] (R-HSA-212594)	0.591	3
UniProt:P29353-7 SHC1			0.581	4
UniProt:Q01973 ROR1	2	ROR1 [plasma membrane] (R-HSA-197814) ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727)	0.576	8
UniProt:P17936 IGFBP3	15	IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) IGFBP3 [extracellular region] (R-HSA-381512) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454)	0.576	3
UniProt:P23470 PTPRG			0.573	3
UniProt:Q92622 RUBIC			0.564	3
UniProt:P07947 YES1	2	YES1 [cytosol] (R-HSA-373640) MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411)	0.564	3
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.564	2
UniProt:P62994 Grb2	3	Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) Grb2 [cytosol] (R-RNO-74686)	0.564	5
UniProt:Q8IZV2 CKLF8			0.556	3
UniProt:O75674 TM1L1			0.556	6
UniProt:P97313	4	Prkdc [cytosol] (R-MMU-3134816) Prkdc [cytosol] (R-MMU-8938766) Prkdc [nucleoplasm] (R-MMU-62161) phospho-Prkdc [nucleoplasm] (R-MMU-76302)	0.556	4
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.553	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.553	2
UniProt:P05107 ITGB2	4	ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [plasma membrane] (R-HSA-198010)	0.553	2
UniProt:P40925 MDH1	1	MDH1 [cytosol] (R-HSA-198471)	0.553	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.553	2
UniProt:O00170 AIP	2	AIP [cytosol] (R-HSA-8936839) AIP [nucleoplasm] (R-HSA-8937156)	0.553	2
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.553	2
UniProt:Q9H299 SH3L3			0.553	2
UniProt:Q8N111 CEND			0.553	2
UniProt:Q59GR8 Q59GR8			0.553	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [cytosol] (R-HSA-380285)	0.553	2
UniProt:Q59G22 Q59G22			0.553	2
UniProt:P16930 FAH	1	FAH [cytosol] (R-HSA-71174)	0.553	2
UniProt:Q13491 GPM6B			0.553	2
UniProt:A4FU49 SH321			0.553	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.553	2
UniProt:O95433 AHSA1			0.553	2
UniProt:Q06830 PRDX1	3	HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) PRDX1 [cytosol] (R-HSA-3341270) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.553	2
UniProt:Q7L273 KCTD9			0.553	2
UniProt:Q4KWH8 PLCH1	1	PLCH1 [plasma membrane] (R-HSA-2023859)	0.553	2
UniProt:O15511 ARPC5	4	ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [cytosol] (R-HSA-200806)	0.553	2
UniProt:P55036 PSMD4	2	PSMD4 [cytosol] (R-HSA-68800) PSMD4 [nucleoplasm] (R-HSA-174330)	0.553	2
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.553	2
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.553	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.553	2
UniProt:Q9NZM3 ITSN2	1	ITSN2 [cytosol] (R-HSA-8862264)	0.553	2
UniProt:P31321 PRKAR1B	2	PRKAR1B [ciliary base] (R-HSA-5610409) PRKAR1B [cytosol] (R-HSA-57838)	0.553	2
UniProt:P19438 TNFRSF1A	3	TNFRSF1A [plasma membrane] (R-HSA-5675738) TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(22-455) [plasma membrane] (R-HSA-66344)	0.553	2
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.553	2
UniProt:P06132 UROD	1	UROD [cytosol] (R-HSA-189427)	0.553	2
UniProt:P04075 ALDOA	6	ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [extracellular region] (R-HSA-349735) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [cytosol] (R-HSA-71492)	0.553	2
UniProt:Q8TDI0 CHD5			0.553	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [cytosol] (R-HSA-5618108)	0.553	2
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.553	2
UniProt:Q8N2Y8 RUSC2			0.553	2
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.553	2
UniProt:Q53GZ6 Q53GZ6			0.553	2
UniProt:P17600 SYN1	1	SYN1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-380577)	0.553	2
UniProt:P31939 ATIC	1	ATIC [cytosol] (R-HSA-62506)	0.553	2
UniProt:P54368 OAZ1	1	OAZ1 [cytosol] (R-HSA-350587)	0.553	2
UniProt:Q9UPY6 WASF3	3	p-Y151-WASF3 [cytosol] (R-HSA-2029006) WASF3 [cytosol] (R-HSA-200975) p-Y151,S,T-WASF3 [cytosol] (R-HSA-5672385)	0.553	2
UniProt:P17174 GOT1	1	PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)	0.553	2
UniProt:Q9NNZ3 DNJC4			0.553	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytosol] (R-HSA-8867737) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.553	2
UniProt:Q14050 COL9A3	48	GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179194) GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179198) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179210) 3x4Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179209) 3x4Hyp-GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179203) 3x4Hyp-3Hyp-GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179201) COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179195) 3x4Hyp-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179208) 3Hyp-4Hyp-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179192) 3x4Hyp-5Hyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179200) 3x4Hyp-3Hyp-5Hyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179196) COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179193) 3x4Hyp-GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470426) COL9A3(?-684) [extracellular region] (R-HSA-2470427) GlcGalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470430) 3x4Hyp-5Hyl-COL9A3(26-?) [extracellular region] (R-HSA-2470398) 3x4Hyp-3Hyp-5Hyl-COL9A3(?-684) [extracellular region] (R-HSA-2470431) 3x4Hyp-3Hyp-5Hyl-COL9A3(26-?) [extracellular region] (R-HSA-2470397) 3x4Hyp-5Hyl-COL9A3(?-684) [extracellular region] (R-HSA-2470450) 3Hyp-4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470384) 3x4Hyp-3Hyp-GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470416) 3x4Hyp-GlcGalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470448) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470417) GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470449) 3x4Hyp-GlcGalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470390) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470422) 3x4Hyp-COL9A3(26-?) [extracellular region] (R-HSA-2470391) 3Hyp-4Hyp-COL9A3(26-?) [extracellular region] (R-HSA-2470388) COL9A3(?-684) [extracellular region] (R-HSA-2470440) GlcGalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470408) COL9A3(26-?) [extracellular region] (R-HSA-2470441) 3Hyp-4Hyp-COL9A3 [extracellular region] (R-HSA-2193009) GalHyl-COL9A3 [extracellular region] (R-HSA-2192976) 3x4Hyp-COL9A3 [extracellular region] (R-HSA-2192931) COL9A3 [extracellular region] (R-HSA-375063) 3x4Hyp-3Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2192946) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192978) GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192962) 3x4Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193029) 3x4Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192981) 3x4Hyp-3Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193030) 3x4Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2193003) 5Hyl-COL9A3 [extracellular region] (R-HSA-2193022) 3x4Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470434) 3x4Hyp-3Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470413) 3x4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470381) GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470412) COL9A3(26-?) [extracellular region] (R-HSA-2470446)	0.553	2
UniProt:O94992 HEXI1			0.553	2
UniProt:Q9Y3A3 PHOCN			0.553	2
UniProt:Q96AD5 PNPLA2	3	PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956776) p-PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956923) PNPLA2 [endoplasmic reticulum membrane] (R-HSA-1498814)	0.553	2
UniProt:P14923 JUP	5	JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739) JUP [extracellular region] (R-HSA-6806309) JUP [specific granule lumen] (R-HSA-6799534) JUP [plasma membrane] (R-HSA-437260)	0.553	2
UniProt:O94875 SRBS2			0.553	2
UniProt:Q15819 UBE2V2	2	UBE2V2 [nucleoplasm] (R-HSA-5682543) UBE2V2 [cytosol] (R-HSA-947624)	0.553	2
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.553	2
UniProt:Q6UWJ1 TMCO3			0.553	2
UniProt:Q99784 NOE1			0.553	2
UniProt:Q92918 M4K1			0.553	2
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.553	2
UniProt:P49798 RGS4	1	RGS4 [plasma membrane] (R-HSA-921135)	0.553	2
UniProt:O75095 MEGF6			0.553	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.553	2
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.553	2
UniProt:Q8N5H7 SH2D3			0.553	2
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.553	2
UniProt:Q02297 NRG1	1	NRG1 [extracellular region] (R-HSA-1227951)	0.553	2
UniProt:Q9H6Q3 SLA2	1	SLA2 [cytosol] (R-HSA-9706161)	0.553	2
UniProt:P52306 GDS1			0.553	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.553	2
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.553	2
UniProt:Q59EJ3 Q59EJ3			0.553	2
UniProt:P52630 STAT2	4	STAT2 [cytosol] (R-HSA-882029) p-Y-STAT2 [cytosol] (R-HSA-8987235) p-Y690-STAT2 [cytosol] (R-HSA-909683) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673)	0.553	2
UniProt:P43243 MATR3			0.553	2
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.553	2
UniProt:P49908 SELENOP	2	SEPP1 [platelet dense granule lumen] (R-HSA-8848897) SEPP1 [extracellular region] (R-HSA-8848887)	0.553	2
UniProt:Q8TDB4 HUMMR			0.553	2
UniProt:Q02156 PRKCE	2	p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260) PRKCE [cytosol] (R-HSA-58202)	0.553	2
UniProt:Q9Y237 PIN4			0.553	2
UniProt:Q16620 NTRK2	6	p-5Y,S479-NTRK2 [plasma membrane] (R-HSA-9032864) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044) NTRK2 [plasma membrane] (R-HSA-6798236) p-5Y-NTRK2 [plasma membrane] (R-HSA-9026475) p-5Y-NTRK2 [Golgi membrane] (R-HSA-3008809) NTRK2 [Golgi membrane] (R-HSA-3008801)	0.553	2
UniProt:P26641 EEF1G	1	EEF1G [cytosol] (R-HSA-156925)	0.553	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.553	2
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.553	2
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.553	2
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.553	2
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [azurophil granule lumen] (R-HSA-6799142) FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235)	0.553	2
UniProt:P11309 PIM1	1	PIM1 [nucleoplasm] (R-HSA-3215094)	0.553	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.553	2
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.553	2
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.553	2
UniProt:Q02246 CNTN2	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.553	2
UniProt:P30307 CDC25C	8	p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668) CDC25C [cytosol] (R-HSA-157879) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741)	0.553	2
UniProt:Q99963 SH3GL3