Reactome | EGFRvIII [plasma membrane]

EGFRvIII [plasma membrane]

Stable Identifier

R-HSA-1214162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EGFR V30_R297delinsG mutant, Epidermal Growth Factor Receptor V30_R297delinsG mutant, EGFR Val30_Arg297delinsGly mutant

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General

EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRvIII, is found in ~25% high-grade glioblastomas and can also be found in squamous cell carcinoma of the lung. EGFRvIII lacks the ligand biding domain and is constitutively active.

External Reference Information

External Reference

UniProt:P00533 EGFR

Gene Names

EGFR, ERBB, ERBB1, HER1

Chain

signal peptide:1-24, chain:25-1210

Reference Genes

BioGPS Gene:1956 EGFR

COSMIC (genes):EGFR EGFR

CTD Gene:1956 EGFR

dbSNP Gene:1956 EGFR

ENSEMBL:ENSG00000146648 EGFR

HGNC:3236 EGFR

KEGG Gene (Homo sapiens):1956 EGFR

Monarch:1956 EGFR

NCBI Gene:1956 EGFR

OMIM:131550 EGFR

UCSC:P00533 EGFR

Reference Transcript

Other Identifiers

0000840253

0002940025

0005900148

0006350504

11725102_at

11725103_s_at

11725104_a_at

11733760_a_at

11738815_at

11742247_a_at

11751983_a_at

1200

1537_at

1565483_at

1565484_x_at

17046135

18530

1956

1DNQ

1DNR

1IVO

1M14

1M17

1MOX

1NQL

1XKK

1YY9

1Z9I

201983_s_at

201984_s_at

210984_x_at

211550_at

211607_x_at

224999_at

2EB2

2EB3

2EXP

2EXQ

2GS2

2GS6

2GS7

2ITN

2ITO

2ITP

2ITQ

2ITT

2ITU

2ITV

2ITW

2ITX

2ITY

2ITZ

2J5E

2J5F

2J6M

2JIT

2JIU

2JIV

2KS1

2M0B

2M20

2N5S

2RF9

2RFD

2RFE

2RGP

3002641

3002642

3002729

3002731

3002733

3002738

3002741

3002743

3002747

3002749

3002750

3002751

3002753

3002757

3002760

3002761

3002763

3002767

3002769

3002770

3002771

3002775

3002776

3002778

3002779

3002786

3002798

3002800

3002801

3002802

3002806

3002807

3002808

3002811

3002812

3002813

3002814

3002815

3002816

3002817

3002818

3002819

3002820

3002821

3002822

3002823

3002824

3002825

37327_at

3B2U

3B2V

3BEL

3BUO

3C09

3G5V

3G5Y

3GT8

3IKA

3LZB

3NJP

3OB2

3OP0

3P0Y

3PFV

3POZ

3QWQ

3UG1

3UG2

3VJN

3VJO

3VRP

3VRR

3W2O

3W2P

3W2Q

3W2R

3W2S

3W32

3W33

48285_at

4G5J

4G5P

4HJO

4I1Z

4I20

4I21

4I22

4I23

4I24

4JQ7

4JQ8

4JR3

4JRV

4KRL

4KRM

4KRO

4KRP

4LI5

4LL0

4LQM

4LRM

4R3P

4R3R

4R5S

4RIW

4RIX

4RIY

4RJ4

4RJ5

4RJ6

4RJ7

4RJ8

4TKS

4UIP

4UV7

4WD5

4WKQ

4WRG

4ZAU

4ZJV

4ZSE

5C8K

5C8M

5C8N

5CAL

5CAN

5CAO

5CAP

5CAQ

5CAS

5CAU

5CAV

5CNN

5CNO

5CZH

5CZI

5D41

5EDP

5EDQ

5EDR

5EM5

5EM6

5EM7

5EM8

5FED

5FEE

5FEQ

5GMP

5GNK

5GTY

5GTZ

5HCX

5HCY

5HCZ

5HG5

5HG7

5HG8

5HG9

5HIB

5HIC

5J9Y

5J9Z

5JEB

5LV6

5SX4

5SX5

5U8L

5UG8

5UG9

5UGA

5UGB

5UGC

5UWD

5WB7

5WB8

5X26

5X27

5X28

5X2A

5X2C

5X2F

5X2K

5XDK

5XDL

5XGM

5XGN

5XWD

5Y25

5Y9T

5YU9

5ZWJ

65700_at

68186

6ARU

6B3S

6D8E

73534

8132860

A0A1W2PRR9

A_14_P106592

A_23_P215790

A_33_P3351944

A_33_P3351955

AAA52370

AAA63171

AAB53063

AAC50796

AAC50797

AAC50798

AAC50799

AAC50800

AAC50801

AAC50802

AAC50804

AAG35786

AAG35787

AAG35788

AAG35789

AAG35790

AAG43240

AAG43243

AAK01080

AAS83109

AAT97979

AF125253

AF125538

AF125539

AF277897

AF288738

AY588246

AY698024

C9JYS6

CAA25240

CAA25282

CAA29668

CAB000035

CAB068186

CAB073534

CCDS47587

CCDS5514

CCDS5515

CCDS5516

E9PFD7

EGFR

EGFR-201

EGFR-202

EGFR-203

EGFR-204

ENSG00000146648

ENSP00000275493

ENSP00000342376

ENSP00000345973

ENSP00000413843

ENST00000275493

ENST00000275493.6

ENST00000342916

ENST00000342916.7

ENST00000344576

ENST00000344576.6

ENST00000420316

ENST00000420316.6

EntrezGene:1956

EntrezGene:EGFR

g12002211_3p_at

g1628549_3p_s_at

g4885198_3p_a_at

GE59632

GE85333

GO:0000003

GO:0000139

GO:0000165

GO:0000166

GO:0000186

GO:0000278

GO:0000902

GO:0001503

GO:0001618

GO:0001889

GO:0001892

GO:0001934

GO:0001942

GO:0003013

GO:0003674

GO:0003677

GO:0003682

GO:0003690

GO:0004672

GO:0004709

GO:0004713

GO:0004714

GO:0004888

GO:0005006

GO:0005102

GO:0005178

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005887

GO:0005925

GO:0006259

GO:0006357

GO:0006412

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0006970

GO:0006979

GO:0007049

GO:0007155

GO:0007165

GO:0007166

GO:0007169

GO:0007173

GO:0007202

GO:0007267

GO:0007275

GO:0007435

GO:0007494

GO:0007611

GO:0007623

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008544

GO:0009056

GO:0009058

GO:0009790

GO:0009925

GO:0009986

GO:0010008

GO:0010750

GO:0010960

GO:0014066

GO:0014070

GO:0016020

GO:0016021

GO:0016101

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0019903

GO:0021795

GO:0030139

GO:0030154

GO:0030234

GO:0030235

GO:0030307

GO:0030324

GO:0030335

GO:0030665

GO:0031410

GO:0031625

GO:0031901

GO:0031965

GO:0032355

GO:0032930

GO:0032991

GO:0033138

GO:0033590

GO:0033594

GO:0033993

GO:0034614

GO:0034641

GO:0035556

GO:0035690

GO:0038083

GO:0038128

GO:0040007

GO:0040011

GO:0042059

GO:0042060

GO:0042127

GO:0042177

GO:0042327

GO:0042592

GO:0042698

GO:0042743

GO:0042802

GO:0043006

GO:0043066

GO:0043167

GO:0043226

GO:0043235

GO:0043406

GO:0043586

GO:0044403

GO:0045121

GO:0045202

GO:0045296

GO:0045737

GO:0045739

GO:0045740

GO:0045746

GO:0045780

GO:0045893

GO:0045907

GO:0045930

GO:0045944

GO:0046328

GO:0046718

GO:0046777

GO:0046982

GO:0048143

GO:0048146

GO:0048408

GO:0048471

GO:0048546

GO:0048661

GO:0048812

GO:0048856

GO:0048870

GO:0050679

GO:0050729

GO:0050730

GO:0050877

GO:0050999

GO:0051015

GO:0051186

GO:0051205

GO:0051592

GO:0051897

GO:0051968

GO:0060571

GO:0061024

GO:0061029

GO:0070141

GO:0070372

GO:0070374

GO:0070435

GO:0071230

GO:0071260

GO:0071276

GO:0071363

GO:0071364

GO:0071392

GO:0071549

GO:0090263

GO:0097421

GO:0097489

GO:0097755

GO:0098609

GO:1900020

GO:1900087

GO:1901185

GO:1901224

GO:1902722

GO:1903078

GO:1903800

GO:1905208

GO:2000145

HGNC:3236

HPA001200

HPA018530

Hs.279898.0.S1_3p_at

Hs.77432.0.S1_3p_a_at

Hs2.367845.1.S1_3p_at

Hs2.367845.1.S1_3p_x_at

ILMN_1728858

ILMN_1755535

ILMN_1798975

ILMN_1905285

IPR000494

IPR000719

IPR001245

IPR006211

IPR006212

IPR008266

IPR009030

IPR011009

IPR016245

IPR017441

IPR020635

IPR032778

IPR036941

LRG_304

M11234

M38425

MIM:131550

MIM:211980

MIM:616069

NM_001346900

NM_005228

NM_201282

NM_201283

NM_201284

NP_001333829

NP_005219

NP_958439

NP_958440

NP_958441

PF00757

PF01030

PF07714

PF14843

PH_hs_0004462

PH_hs_0014421

PR00109

Q504U8

SM00219

SM00261

TC07000328.hg

TC07002321.hg

TC07002322.hg

U48722

U48723

U48724

U48725

U48726

U48727

U48728

U48729

U95089

UPI000002A8C9

UPI000002A8CA

UPI000002A8CB

UPI000003E750

X00588

X00588_at

X00663

X06370

Participant Of

input

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37.

hasComponent

EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Other forms of this molecule

p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]

p-5Y-EGFRvIII [plasma membrane]

p-6Y-EGFR E746_A750del;T790M [plasma membrane]

p-6Y-EGFR L858R;T790M [plasma membrane]

p-6Y-EGFR M766_A767insASV [plasma membrane]

p-6Y-EGFR D770_N771insNPH [plasma membrane]

p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]

p-6Y-EGFR D770_N771insNPG [plasma membrane]

p-6Y-EGFR E746_A750del [plasma membrane]

p-6Y-EGFR L858R [plasma membrane]

p-6Y-EGFR G719S [plasma membrane]

p-6Y-EGFR L747_P753delinsS [plasma membrane]

p-6Y-EGFR L747_A750delinsP [plasma membrane]

p-6Y-EGFR L747_T751del [plasma membrane]

p-6Y-EGFR L747_S752del [plasma membrane]

p-6Y-EGFR L747_T751delinsP [plasma membrane]

p-6Y-EGFR E746_T751delinsA [plasma membrane]

p-6Y-EGFR E746_S752delinsV [plasma membrane]

p-6Y-EGFR L861Q [plasma membrane]

p-6Y-EGFR A289V [plasma membrane]

p-6Y-EGFR T263P [plasma membrane]

p-6Y-EGFR G598V [plasma membrane]

p-6Y-EGFR R108K [plasma membrane]

p-6Y-EGFR A289T [plasma membrane]

p-6Y-EGFR G719C [plasma membrane]

p-6Y-EGFR A289D [plasma membrane]

p-6Y-EGFR G719A [plasma membrane]

EGFR L858R;T790M [plasma membrane]

EGFR E746_A750del;T790M [plasma membrane]

EGFR D770_N771insNPG [plasma membrane]

EGFR V738_K739insKIPVAI [plasma membrane]

EGFR M766_A767insASV [plasma membrane]

EGFR D770_N771insNPH [plasma membrane]

EGFR L858R [plasma membrane]

EGFR G719S [plasma membrane]

EGFR E746_A750del [plasma membrane]

EGFR L747_P753delinsS [plasma membrane]

EGFR A289V [plasma membrane]

EGFR L747_T751delinsP [plasma membrane]

EGFR L747_T751del [plasma membrane]

EGFR A289D [plasma membrane]

EGFR L861Q [plasma membrane]

EGFR R108K [plasma membrane]

EGFR L747_A750delinsP [plasma membrane]

EGFR E746_T751delinsA [plasma membrane]

EGFR G719A [plasma membrane]

EGFR A289T [plasma membrane]

EGFR E746_S752delinsV [plasma membrane]

EGFR G719C [plasma membrane]

EGFR T263P [plasma membrane]

EGFR G598V [plasma membrane]

EGFR L747_S752del [plasma membrane]

p-4Y-EGFR [plasma membrane]

p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]

p-Y1086,Y1101-EGFR [plasma membrane]

EGFR [plasma membrane]

p-6Y-EGFR [plasma membrane]

Modified Residues

Name

Deletion of residues 30 to 296

Name

L-arginine 297 replaced with glycine

Coordinate

297

PsiMod

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

Disease

Name	Identifier	Synonyms
brain glioma	0060108
cancer	162	malignant tumor, malignant neoplasm, primary cancer
glioblastoma multiforme	3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
lung squamous cell carcinoma	3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
astrocytoma	3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma

Cross References

RefSeq

NP_958441.1, NP_958440.1, NP_005219.2, NP_958439.1

ZINC - World Drugs

EGFR_HUMAN

OpenTargets

ENSG00000146648

ZINC - FDA approved

EGFR_HUMAN

ZINC - Substances

EGFR_HUMAN

ZINC target

P00533

ZINC - Biogenic

EGFR_HUMAN

PRO

P00533

PDB

4WD5, 5C8K, 2ITU, 2KS1, 5Y9T, 2J5E, 4RJ4, 2ITO, 2M20, 4LL0, 5CAL, 4RJ8, 4I20, 4KRP, 5HCY, 3W33, 2RFE, 4JQ8, 4LRM, 4G5J, 5CNN, 3W2P, 2RGP, 5CAS, 5UG9, 5J9Z, 3VRR, 2ITQ, 5X2F, 2ITW, 2EB2, 3POZ, 3W2S, 4RJ6, 2JIT, 1YY9, 3C09, 2GS6, 1M17, 1IVO, 5XDK, 2N5S, 5HG5, 5U8L, 5CZI, 5JEB, 5FED, 5EM7, 5ZTO, 5GTZ, 3W2Q, 5HIC, 3NJP, 5XGN, 6ARU, 4I21, 2EXP, 5HG8, 4RIX, 5GNK, 4ZJV, 3G5V, 3GOP, 5LV6, 2ITY, 5HCZ, 1M14, 3VJN, 5UWD, 5EM6, 5UGA, 5C8N, 5FEQ, 3UG1, 5CAU, 5SX4, 4JR3, 5EDP, 2JIU, 1DNQ, 3OP0, 5Y25, 5HCX, 4KRL, 2J5F, 5X28, 4WKQ, 5WB8, 4G5P, 5UG8, 5CAQ, 5EDR, 2ITZ, 5J9Y, 4RIY, 6DUK, 4I22, 5C8M, 2ITV, 6D8E, 2ITP, 5X2C, 5CAN, 4I1Z, 4RJ7, 3VJO, 5X26, 3W32, 2RFD, 4UV7, 4JQ7, 5CZH, 1DNR, 3W2O, 4HJO, 5CNO, 3LZB, 4R3R, 4UIP, 5YU9, 4ZSE, 5GMP, 2JIV, 2GS2, 5GTY, 4ZAU, 2ITT, 5X2K, 4I24, 2ITN, 3W2R, 1XKK, 5HIB, 5XWD, 5UGC, 4RJ5, 4TKS, 2GS7, 5XGM, 4JRV, 4LQM, 2EB3, 4R3P, 2RF9, 3GT8, 5HG7, 3IKA, 2EXQ, 3G5Y, 5X2A, 5XDL, 5ZWJ, 2J6M, 3P0Y, 5D41, 5FEE, 4I23, 5EM5, 4KRO, 3VRP, 1Z9I, 3UG2, 3OB2, 4RIW, 3PFV, 5EM8, 4R5S, 4WRG, 5HG9, 1MOX, 5CAO, 3B2V, 3BUO, 5WB7, 3BEL, 1NQL, 4KRM, 5X27, 4LI5, 3B2U, 2ITX, 5UGB, 6B3S, 2M0B, 5EDQ, 5CAP, 5SX5, 3QWQ, 5CAV

ZINC - Investigational

EGFR_HUMAN

ZINC - Metabolites

EGFR_HUMAN

COSMIC

21351

GeneCards

P00533

Orphanet

15917

ZINC - Predictions - Purchasable

EGFR_HUMAN

HMDB Protein

HMDBP01456

Interactors (158)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.978	26
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.978	47
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.97	37
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) CBL [cytosol] (R-HSA-112199) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.964	26
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.96	25
UniProt:P01133 EGF	5	Pro-EGF [extracellular region] (R-HSA-54209) EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086) Pro-EGF [platelet alpha granule lumen] (R-HSA-139875) Pro-EGF [plasma membrane] (R-HSA-179888) EGF [extracellular region] (R-HSA-179863)	0.957	21
UniProt:P21860 ERBB3			0.916	13
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-S727-STAT3 [cytosol] (R-HSA-198705) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048)	0.893	14
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.863	8
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.85	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463)	0.839	8
UniProt:Q9UJM3 ERRFI			0.826	13
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.822	7
UniProt:P08107 HSP71			0.809	6
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.809	6
UniProt:P20417	1	PTPN1 [cytosol] (R-RNO-210625)	0.802	11
UniProt:P08581 MET	7	p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.8	8
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.779	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.779	8
UniProt:P15941 MUC1	19	Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.766	5
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.763	6
UniProt:P62158 CALM			0.756	4
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.755	9
UniProt:Q9UBN7 HDAC6	3	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404)	0.753	11
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.752	6
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.747	4
UniProt:P16885 PLCG2	10	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.744	5
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.721	6
UniProt:P10599 TXN	4	TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.721	4
UniProt:P11142 HSPA8	10	HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.716	5
UniProt:P42224 STAT1	7	p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.706	6
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.704	6
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.704	4
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.704	5
UniProt:P04083 ANXA1	2	ANXA1 [extracellular region] (R-HSA-444539) ANXA1 [cytosol] (R-HSA-5263630)	0.701	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.701	5
UniProt:P46109 CRKL	2	p-CRKL [cytosol] (R-HSA-9024730) CRKL [cytosol] (R-HSA-354384)	0.692	4
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) EIF2C2 [nucleoplasm] (R-HSA-5578701)	0.679	11
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940)	0.678	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.669	3
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.669	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.667	5
UniProt:Q71U36 TUBA1A	9	TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A [cytosol] (R-HSA-191689) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.659	3
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.659	4
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [nucleoplasm] (R-HSA-5252128)	0.659	4
UniProt:Q92625 ANS1A			0.658	5
UniProt:Q92870 APBB2			0.658	6
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.658	3
UniProt:Q13322 GRB10	1	GRB10 [cytosol] (R-HSA-110009)	0.646	3
UniProt:Q8NBJ4 GOLM1	2	GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710) p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938)	0.644	13
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.643	5
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.635	3
UniProt:Q14457 BECN1	3	p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.628	7
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) SH3KBP1 [plasma membrane] (R-HSA-182955) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.623	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.623	9
UniProt:O14965 AURKA	6	AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.602	4
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.599	4
UniProt:Q86VI4 LAP4B			0.599	10
UniProt:P07992 ERCC1	2	ERCC1 [nucleoplasm] (R-HSA-54427) Ub-ERCC1 [nucleoplasm] (R-HSA-5696473)	0.599	21
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.592	3
UniProt:Q13387 JIP2			0.592	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.592	3
UniProt:P00519 ABL1	5	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [nucleoplasm] (R-HSA-5686579) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.592	2
UniProt:Q13239 SLAP1			0.592	2
UniProt:P23467 PTPRB	3	PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032) PTPRB [specific granule membrane] (R-HSA-6799638)	0.592	2
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.592	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.592	8
UniProt:P43403 ZAP70	3	p-Y493-ZAP70 [cytosol] (R-HSA-202368) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252) ZAP70 [cytosol] (R-HSA-202397)	0.592	2
UniProt:P01135 TGFA	5	TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841) TGFA(24-98) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817) TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840) TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476) TGFA(24-98) [extracellular region] (R-HSA-9624183)	0.592	2
UniProt:P51451 BLK	2	BLK [cytosol] (R-HSA-983580) MyrG2-BLK [plasma membrane] (R-HSA-9606871)	0.592	2
UniProt:P14174 MIF	3	MIF [extracellular region] (R-HSA-212594) MIF [secretory granule lumen] (R-HSA-6803282) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.591	3
UniProt:P16234 PDGFRA	2	PDGFRA [plasma membrane] (R-HSA-186794) p-11Y-PDGFRA [plasma membrane] (R-HSA-186806)	0.581	3
UniProt:P29353-7 SHC1			0.581	4
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.581	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.581	4
UniProt:P17936 IGFBP3	15	IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(125-233) [extracellular region] (R-HSA-381465) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) IGFBP3 [extracellular region] (R-HSA-381512)	0.576	3
UniProt:Q01973 ROR1	2	ROR1 [plasma membrane] (R-HSA-197814) ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727)	0.576	8
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.573	2
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.573	2
UniProt:O60603 TLR2	2	TLR2 [plasma membrane] (R-HSA-167992) TLR2 [secretory granule membrane] (R-HSA-6804777)	0.573	2
UniProt:O75368 SH3L1			0.573	2
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.573	3
UniProt:Q99962 SH3GL2	4	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958)	0.573	3
UniProt:Q92622 RUBIC			0.564	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:O75674 TM1L1			0.556	6
UniProt:Q8IZV2 CKLF8			0.556	3
UniProt:P97313	4	PRKDC [cytosol] (R-MMU-3134816) K48polyUb-PRKDC [cytosol] (R-MMU-8938766) PRKDC [nucleoplasm] (R-MMU-62161) phospho-p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-MMU-76302)	0.556	4
UniProt:P34932 HSPA4	2	HSPA4 [nucleoplasm] (R-HSA-5251998) HSPA4 [cytosol] (R-HSA-5251946)	0.553	2
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747) CFL1 [cytosol] (R-HSA-350751)	0.553	2
UniProt:Q09666 AHNK			0.547	3
UniProt:P51636 CAV2	2	CAV2 [Golgi membrane] (R-HSA-9021032) CAV2 [plasma membrane] (R-HSA-9021035)	0.547	2
UniProt:Q05397 PTK2	11	p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.547	3
UniProt:P29350 PTPN6	5	PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952)	0.547	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [lysosomal membrane] (R-HSA-196144) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.547	4
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14-CDK1 [nucleoplasm] (R-HSA-170045)	0.547	2
UniProt:Q13480 GAB1	4	p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.547	3
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.547	2
UniProt:Q14956-1 GPNMB			0.544	2
UniProt:Q38SD2 LRRK1			0.544	2
UniProt:P07948-1 LYN			0.544	2
UniProt:P68366 TUBA4A	9	Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318) TUBA4A folding intermediate [cytosol] (R-HSA-392800) TUBA4A unfolded [cytosol] (R-HSA-392771) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) TUBA4A [extracellular region] (R-HSA-350734) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [cytosol] (R-HSA-191694)	0.527	2
UniProt:Q9UQC2 GAB2	4	p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-5Y-GAB2 [cytosol] (R-HSA-8855574) GAB2 [cytosol] (R-HSA-508239) p-Y-GAB2 [cytosol] (R-HSA-912529)	0.527	2
UniProt:Q00325 MPCP			0.527	3
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	2
UniProt:O95782 AP2A1	5	AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143)	0.527	4
UniProt:P11021 HSPA5	6	HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190)	0.527	5
UniProt:Q9H0D6 XRN2	2	XRN2 [cytosol] (R-HSA-391297) XRN2 [nucleoplasm] (R-HSA-6791205)	0.527	5
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.527	2
UniProt:Q14956 GPNMB	2	GPNMB [plasma membrane] (R-HSA-8857550) p-Y525-GPNMB [plasma membrane] (R-HSA-8857558)	0.524	3
UniProt:P62161 CALM			0.524	6
UniProt:P03372-4 ESR1	4	PalmS-ER alpha36 [plasma membrane] (R-HSA-9021053) PalmS-ER alpha36 [cytosol] (R-HSA-9020988) Me87-PalmS-ER alpha36 [plasma membrane] (R-HSA-9637786) ER alpha36 [cytosol] (R-HSA-9020981)	0.524	4
UniProt:P13866 SLC5A1	8	SLC5A1 R135W [plasma membrane] (R-HSA-5656381) SLC5A1 D28N [plasma membrane] (R-HSA-5656362) SLC5A1 D28G [plasma membrane] (R-HSA-5656368) SLC5A1 R379* [plasma membrane] (R-HSA-5656370) SLC5A1 Q457R [plasma membrane] (R-HSA-5656354) SLC5A1 G100V [plasma membrane] (R-HSA-5656373) SLC5A1 Y191* [plasma membrane] (R-HSA-5656372) SLC5A1 [plasma membrane] (R-HSA-189243)	0.524	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.524	2
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.524	4
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.508	2
UniProt:Q6S5L8 SHC4			0.508	2
UniProt:P04150 NR3C1	3	NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [nucleoplasm] (R-HSA-879837)	0.508	2
UniProt:P46108-1 CRK			0.508	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.508	2
UniProt:Q9HD43 PTPRH			0.508	3
UniProt:Q9Y2H9 MAST1			0.508	2
UniProt:Q12929 EPS8			0.508	2
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920) VAPA [plasma membrane] (R-HSA-6806269) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.508	2
UniProt:P42229 STAT5A	5	p-Y649-STAT5A [cytosol] (R-HSA-8980151) p-STAT5A [nucleoplasm] (R-HSA-8982836) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.508	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.508	3
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.508	2
UniProt:Q02952 AKA12			0.508	2
UniProt:Q9BRG2 SH23A			0.508	2
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.508	2
UniProt:O43561 LAT	3	LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.508	2
UniProt:P09769 FGR	3	FGR [secretory granule lumen] (R-HSA-6804974) FGR [extracellular region] (R-HSA-6806524) FGR [cytosol] (R-HSA-432116)	0.508	2
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.508	2
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.508	2
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.508	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.508	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.508	2
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.508	2
UniProt:P17252 PRKCA	8	PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [plasma membrane] (R-HSA-156469) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [cytosol] (R-HSA-58196)	0.508	2
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.508	2
IntAct:EBI-4399559 UBIQ			0.499	3
UniProt:Q80U62 RUBIC			0.499	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.499	8
UniProt:P22682	6	phospho-p-Y371-CBL [plasma membrane] (R-MMU-182923) phospho-p-Y-CBL [cytosol] (R-MMU-8875457) phospho-p-Y371-CBL [cytosol] (R-MMU-182940) CBL [cytosol] (R-MMU-112199) phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-MMU-8848826) phospho-p-Y700,Y731,Y774-CBL [cytosol] (R-MMU-912656)	0.499	2
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.499	2
UniProt:Q12852 M3K12			0.482	2
UniProt:P25098 GRK2	4	p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) GRK2 [plasma membrane] (R-HSA-50270) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318)	0.463	3
UniProt:Q9Y6Q6-2 TNFRSF11A			0.463	3
UniProt:P07355 ANXA2	4	ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667)	0.463	3
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.463	3
UniProt:P0A0I7 AGRA			0.463	2
UniProt:O75886 STAM2	2	STAM2 [cytosol] (R-HSA-182965) Ub-STAM2 [cytosol] (R-HSA-6782781)	0.463	2
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.463	3
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.463	2
UniProt:Q8TF42 UBS3B			0.462	5
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.462	4