Reactome | EGFRvIII [plasma membrane]

EGFRvIII [plasma membrane]

Stable Identifier

R-HSA-1214162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EGFR V30_R297delinsG mutant, Epidermal Growth Factor Receptor V30_R297delinsG mutant, EGFR Val30_Arg297delinsGly mutant

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General

EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRvIII, is found in ~25% high-grade glioblastomas and can also be found in squamous cell carcinoma of the lung. EGFRvIII lacks the ligand biding domain and is constitutively active.

External Reference Information

External Reference

UniProt:P00533 EGFR

Gene Names

EGFR, ERBB, ERBB1, HER1

Chain

signal peptide:1-24, chain:25-1210

Reference Genes

BioGPS Gene:1956 EGFR

COSMIC (genes):EGFR EGFR

CTD Gene:1956 EGFR

dbSNP Gene:1956 EGFR

ENSEMBL:ENSG00000146648 EGFR

HGNC:3236 EGFR

KEGG:hsa:1956 EGFR

Monarch:1956 EGFR

NCBI Gene:1956 EGFR

OMIM:131550 EGFR

UCSC:P00533 EGFR

Reference Transcript

Participates

as an input of

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 (Homo sapiens)

as a component of

EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]

p-5Y-EGFRvIII [plasma membrane]

p-6Y-EGFR E746_A750del;T790M [plasma membrane]

p-6Y-EGFR L858R;T790M [plasma membrane]

p-6Y-EGFR A767_V769dup [plasma membrane]

p-6Y-EGFR N771_H773dup [plasma membrane]

p-6Y-EGFR K739_I744dup [plasma membrane]

p-6Y-EGFR D770_N771insNPG [plasma membrane]

p-6Y-EGFR E746_A750del [plasma membrane]

p-6Y-EGFR L858R [plasma membrane]

p-6Y-EGFR G719S [plasma membrane]

p-6Y-EGFR L747_P753delinsS [plasma membrane]

p-6Y-EGFR L747_A750delinsP [plasma membrane]

p-6Y-EGFR L747_T751del [plasma membrane]

p-6Y-EGFR L747_S752del [plasma membrane]

p-6Y-EGFR L747_T751delinsP [plasma membrane]

p-6Y-EGFR E746_T751delinsA [plasma membrane]

p-6Y-EGFR E746_S752delinsV [plasma membrane]

p-6Y-EGFR L861Q [plasma membrane]

p-6Y-EGFR A289V [plasma membrane]

p-6Y-EGFR T263P [plasma membrane]

p-6Y-EGFR G598V [plasma membrane]

p-6Y-EGFR R108K [plasma membrane]

p-6Y-EGFR A289T [plasma membrane]

p-6Y-EGFR G719C [plasma membrane]

p-6Y-EGFR A289D [plasma membrane]

p-6Y-EGFR G719A [plasma membrane]

EGFR L858R;T790M [plasma membrane]

EGFR E746_A750del;T790M [plasma membrane]

EGFR D770_N771insNPG [plasma membrane]

EGFR K739_I744dup [plasma membrane]

EGFR A767_V769dup [plasma membrane]

EGFR N771_H773dup [plasma membrane]

EGFR L858R [plasma membrane]

EGFR G719S [plasma membrane]

p-6Y-EGFR [plasma membrane]

EGFR [plasma membrane]

p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]

p-4Y-EGFR [plasma membrane]

EGFR [endosome membrane]

EGFR L747_S752del [plasma membrane]

EGFR G598V [plasma membrane]

EGFR T263P [plasma membrane]

EGFR G719C [plasma membrane]

EGFR E746_S752delinsV [plasma membrane]

EGFR A289T [plasma membrane]

EGFR G719A [plasma membrane]

EGFR E746_T751delinsA [plasma membrane]

EGFR L747_A750delinsP [plasma membrane]

EGFR R108K [plasma membrane]

EGFR L861Q [plasma membrane]

EGFR A289D [plasma membrane]

EGFR L747_T751del [plasma membrane]

EGFR L747_T751delinsP [plasma membrane]

EGFR A289V [plasma membrane]

EGFR L747_P753delinsS [plasma membrane]

EGFR E746_A750del [plasma membrane]

Modified Residues

Name

Deletion of residues 30 to 296

Name

L-arginine 297 replaced with glycine

Coordinate

297

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
brain glioma	DOID:0060108
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
lung squamous cell carcinoma	DOID:3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
astrocytoma	DOID:3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma

Cross References

RefSeq

NP_958440.1, NP_958441.1, NP_958439.1, NP_005219.2

ZINC - World Drugs

EGFR_HUMAN

Guide to Pharmacology - Targets

1797

OpenTargets

ENSG00000146648

ENSEMBL

ENST00000275493, ENSP00000275493, ENSG00000146648, ENSP00000413843, ENST00000420316, ENST00000342916, ENST00000344576, ENSP00000342376, ENSP00000345973

ZINC - FDA approved

EGFR_HUMAN

ZINC - Substances

EGFR_HUMAN

ZINC - Biogenic

EGFR_HUMAN

ZINC target

P00533

PRO

P00533

GlyGen

P00533

PDB

5XDK, 5CAN, 8GK5, 8UKV, 5GMP, 7UKW, 3GOP, 6XL4, 4JQ7, 4TKS, 7JXW, 2J6M, 7AEM, 8HV8, 9EWS, 7SI1, 5CNN, 2RFD, 4ZJV, 5HCZ, 8HV5, 5HG5, 5X27, 1NQL, 7T4J, 1M17, 5UGB, 4I20, 4UIP, 3VRR, 6B3S, 6VHP, 8PO4, 6JX4, 6TFV, 3W32, 8SC7, 5Y25, 4WKQ, 5XDL, 2EB3, 2RF9, 4WRG, 7SZ1, 4ZAU, 5FEE, 7SZ5, 5XGM, 7JXQ, 7SZ7, 1M14, 3VJO, 4R5S, 3B2V, 7A6J, 7TVD, 5CNO, 2J5F, 8HVA, 4RJ5, 7T4I, 5WB8, 8HV4, 3UG2, 5UG8, 6V5N, 4RIX, 8PO3, 8EME, 2KS1, 6TFZ, 1XKK, 8FV4, 6JX0, 4I24, 5ZTO, 3W2Q, 7VRA, 5GTZ, 8H7X, 4G5J, 6VHN, 1MOX, 4JRV, 2ITP, 3BUO, 7SZ0, 7JXM, 5CAQ, 7UKV, 3QWQ, 4UV7, 5HCX, 8F1X, 5EDR, 3OB2, 2RFE, 7KXZ, 6V6O, 2ITY, 5X28, 3VRP, 2ITU, 3UG1, 8PO0, 5X2K, 4RJ8, 8GB4, 8TO3, 5X26, 6TFY, 7K1I, 6JWL, 3P0Y, 9H46, 4I1Z, 3OP0, 7A2A, 6WXN, 6P8Q, 6DUK, 8G63, 7ZYQ, 7LG8, 8A2B, 3PFV, 8UKX, 2ITN, 8S1M, 3GT8, 7JXP, 8F1W, 6JZ0, 5CAO, 8HV1, 4KRM, 5HCY, 4LI5, 7A6K, 4RJ4, 3IKA, 5Y9T, 6WAK, 2ITV, 7AEI, 6S9B, 8PO2, 5CZH, 4RIW, 5C8N, 5CAU, 6LUB, 7ER2, 5UGC, 6TFW, 7LTX, 5LV6, 7VRE, 5J9Z, 7LFR, 3W2S, 6JRJ, 4LL0, 7OM4, 2ITQ, 6JRX, 8F1H, 7ZYP, 7B85, 6P1L, 8TJL, 7SYD, 2GS6, 3B2U, 5XGN, 5EDP, 2M20, 4JQ8, 6S9D, 6V6K, 5HIB, 4KRP, 2M0B, 6S9C, 5WB7, 5C8M, 4HJO, 5X2F, 7LEN, 5CAV, 1IVO, 4I23, 6TFU, 5UWD, 3W2P, 4R3R, 3NJP, 5EM7, 6LUD, 4ZSE, 5GTY, 7LFS, 5CAL, 5SX4, 8HGP, 3POZ, 5JEB, 2ITO, 1YY9, 8A2A, 8D73, 5CAP, 7JXI, 7U98, 3BEL, 7A6I, 6V66, 8WD4, 8F1Z, 8A27, 2ITZ, 8HV7, 6Z4D, 2ITW, 5HG8, 2JIT, 5C8K, 4RJ7, 5X2C, 3C09, 4LRM, 5CZI, 5CAS, 8PO1, 8FV3, 3W2O, 5UGA, 4I22, 6S8A, 5EM8, 3W33, 5J9Y, 8HY7, 2GS2, 5SX5, 8HGO, 8A2D, 4G5P, 2RGP, 5U8L, 6VH4, 7JXL, 5FED, 7SYE, 8D76, 2GS7, 6S89, 4JR3, 8HV6, 8KFQ, 5EDQ, 4KRO, 6Z4B, 8HV3, 5HIC, 3VJN, 5HG9, 2JIU, 6JXT, 4RJ6, 6D8E, 4WD5, 3LZB, 4I21, 7K1H, 4R3P, 7U9A, 6ARU, 5EM5, 7OXB, 4LQM, 3W2R, 6JRK, 2N5S, 2EB2, 8UKW, 2ITT, 6P1D, 7ZYN, 8F1Y, 4KRL, 7JXK, 5FEQ, 7KY0, 8PNZ, 7ZYM, 7U99, 3G5V, 1Z9I, 8DSW, 3G5Y, 9EWT, 5HG7, 2J5E, 8HV9, 2ITX, 5YU9, 5ZWJ, 8HV2, 5X2A, 2JIV, 5XWD, 5UG9, 6TG1, 7LGS, 6V5P, 4RIY, 6TG0, 5EM6, 6WA2, 5GNK, 5D41, 8TO4, 8HGS

ZINC - Investigational

EGFR_HUMAN

ZINC - Metabolites

EGFR_HUMAN

COSMIC

COSM21351

GeneCards

EGFR

HPA

ENSG00000146648-EGFR

Pharos - Targets

P00533

Orphanet

EGFR

ZINC - Predictions - Purchasable

EGFR_HUMAN

HMDB Protein

HMDBP01456

Interactors (342)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.983	31
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.983	59
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.976	44
UniProt:P01133 EGF	5	EGF [extracellular region] (R-HSA-179863) Pro-EGF [plasma membrane] (R-HSA-179888) Pro-EGF [platelet alpha granule lumen] (R-HSA-139875) Pro-EGF [extracellular region] (R-HSA-54209) EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086)	0.973	29
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.964	26
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.954	25
UniProt:Q9UJM3 ERRFI			0.927	16
UniProt:P21860 ERBB3			0.925	15
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.925	16
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.91	10
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.898	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.89	10
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.859	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.854	7
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.85	6
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.838	7
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.833	9
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.828	8
UniProt:P62158 CALM			0.828	6
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [secretory granule lumen] (R-HSA-6801515)	0.824	8
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.823	6
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.82	7
UniProt:P15941 MUC1	19	GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) MUC1(24-1255) [plasma membrane] (R-HSA-6793976)	0.819	6
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.813	7
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.811	10
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.81	7
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.809	12
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.807	5
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.803	7
UniProt:P20417	2	Ptpn1 [cytosol] (R-RNO-210625) Ptpn1 [endosome membrane] (R-RNO-9815895)	0.802	11
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)	0.8	8
UniProt:P08107 HSP71			0.799	6
UniProt:Q92625 ANS1A			0.793	7
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.786	13
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.785	7
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.785	5
UniProt:P01135 TGFA	5	TGFA(40-89) [extracellular region] (R-HSA-9624183) TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476) TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840) TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841) TGFA(40-89) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817)	0.779	4
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.774	7
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.773	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.772	6
UniProt:P04083 ANXA1	2	ANXA1 [extracellular region] (R-HSA-444539) ANXA1 [cytosol] (R-HSA-5263630)	0.772	5
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.76	7
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.76	5
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.749	5
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.745	4
UniProt:O60716 CTNND1	2	CTNND1 [plasma membrane] (R-HSA-418996) p-Y-CTNND1 [plasma membrane] (R-HSA-9934835)	0.745	5
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-5Y-PTK2 [cytosol] (R-HSA-5218711) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.745	7
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.745	5
UniProt:P26447 S10A4			0.743	6
UniProt:Q96JA1 LRIG1	2	LRIG1 [plasma membrane] (R-HSA-197745) Ub-LRIG1 [plasma membrane] (R-HSA-8875434)	0.743	6
UniProt:Q92870 APBB2			0.737	7
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.737	4
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.735	4
UniProt:P12830 CDH1	20	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Man,Man9GlucNAc2,p-3S-CDH1 [Golgi membrane] (R-HSA-9933713) CDH1(23-154) [Golgi lumen] (R-HSA-9933717) Man,Man9GlucNAc2,p-3S-CDH1(23-882) [Golgi membrane] (R-HSA-9933166) Man,Man9GlucNAc2,p-3S-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9933653) Man,Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9933097) Glu3Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9932178) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) Man,Man9GlucNAc2,p-3S-CDH1 [plasma membrane] (R-HSA-9933842) Man,Man9GlucNAc2,p-3S,2Y-CDH1 [plasma membrane] (R-HSA-9934836) PolyUb-K740,K818-CDH1 [plasma membrane] (R-HSA-9935242) PolyUb-K740,K818-CDH1 [early endosome membrane] (R-HSA-9935416) PolyUb-K740,K818-CDH1 [lysosomal membrane] (R-HSA-9935544) PolyUbK48-CDH1 [plasma membrane] (R-HSA-9934660)	0.735	4
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.735	5
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.732	6
UniProt:Q13322 GRB10	2	GRB10 [cytosol] (R-HSA-110009) p-Y GRB10 [cytosol] (R-HSA-9706168)	0.729	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.721	4
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.713	4
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.713	4
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.709	8
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.695	4
UniProt:Q13387 JIP2			0.692	5
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.692	4
UniProt:P23467 PTPRB	3	PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032)	0.692	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.692	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.692	9
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.692	3
UniProt:Q13239 SLA	1	SLA [cytosol] (R-HSA-9706158)	0.692	3
UniProt:P43403 ZAP70	3	p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252) p-Y493-ZAP70 [cytosol] (R-HSA-202368) ZAP70 [cytosol] (R-HSA-202397)	0.692	3
UniProt:Q8TF42 UBS3B			0.69	7
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.683	4
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.683	5
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.683	4
UniProt:O75368 SH3L1			0.681	3
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-167992) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646)	0.681	3
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.681	3
UniProt:Q99962 SH3GL2	4	SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.681	4
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.681	4
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.679	11
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143) AP2A1 [plasma membrane] (R-HSA-177494)	0.671	6
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.671	5
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.669	3
UniProt:Q9UQC2 GAB2	5	p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y643-GAB2 [cytosol] (R-HSA-9677149)	0.669	3
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.668	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.668	3
UniProt:Q09666 AHNK			0.667	4
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.667	3
UniProt:P51636 CAV2	2	CAV2 [plasma membrane] (R-HSA-9021035) CAV2 [Golgi membrane] (R-HSA-9021032)	0.667	3
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.653	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.653	4
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.653	3
UniProt:Q9NZM3 ITSN2	1	ITSN2 [cytosol] (R-HSA-8862264)	0.653	3
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.653	3
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.653	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.653	3
UniProt:Q9UPY6 WASF3	3	p-Y151,S,T-WASF3 [cytosol] (R-HSA-5672385) p-Y151-WASF3 [cytosol] (R-HSA-2029006) WASF3 [cytosol] (R-HSA-200975)	0.653	3
UniProt:P17174 GOT1	1	PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)	0.653	3
UniProt:P14923 JUP	7	JUP [plasma membrane] (R-HSA-437260) JUP [cytosol] (R-HSA-201598) p-Y-JUP [cytosol] (R-HSA-9934829) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [extracellular region] (R-HSA-6806309) JUP [specific granule lumen] (R-HSA-6799534) JUP [cornified envelope] (R-HSA-8847739)	0.653	3
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.653	3
UniProt:Q16620 NTRK2	6	p-5Y-NTRK2 [plasma membrane] (R-HSA-9026475) NTRK2 [plasma membrane] (R-HSA-6798236) NTRK2 [Golgi membrane] (R-HSA-3008801) p-5Y-NTRK2 [Golgi membrane] (R-HSA-3008809) p-5Y,S479-NTRK2 [plasma membrane] (R-HSA-9032864) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044)	0.653	3
UniProt:Q92622 RUBIC			0.65	4
UniProt:Q15303 ERBB4			0.65	4
UniProt:Q10567 AP1B1	5	AP1B1 [cytosol] (R-HSA-167705) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181)	0.649	4
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.644	13
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.643	5
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.643	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.635	3
UniProt:P04150 NR3C1	3	NR3C1 [nucleoplasm] (R-HSA-879837) NR3C1 [cytosol] (R-HSA-5618118) SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106)	0.635	3
UniProt:Q9Y2H9 MAST1			0.635	3
UniProt:P42229 STAT5A	4	p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [nucleoplasm] (R-HSA-9701901)	0.635	4
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.635	4
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [plasma membrane] (R-HSA-156469) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.635	3
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.635	3
UniProt:O43561 LAT	3	p-5Y-LAT [plasma membrane] (R-HSA-202364) LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.635	3
UniProt:Q6S5L8 SHC4			0.635	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.635	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.635	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.635	3
UniProt:Q02952 AKAP12	1	AKAP12 [plasma membrane] (R-HSA-9715082)	0.635	3
UniProt:Q9BRG2 SH23A			0.635	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.635	3
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.635	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.635	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.635	3
UniProt:P09769 FGR	3	FGR [cytosol] (R-HSA-432116) FGR [secretory granule lumen] (R-HSA-6804974) FGR [extracellular region] (R-HSA-6806524)	0.635	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.635	4
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.623	3
UniProt:Q12852 M3K12			0.621	3
UniProt:Q6UW88 EPGN	2	EPGN(23-154) [extracellular region] (R-HSA-9624187) EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628815)	0.618	3
UniProt:O14944 EREG	2	EREG(60-108) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628816) EREG(60-108) [extracellular region] (R-HSA-1233233)	0.618	3
UniProt:Q9NS73 MBIP	1	MBIP [nucleoplasm] (R-HSA-3662291)	0.618	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.615	3
UniProt:Q99075 HBEGF	8	HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819) HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776) HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(63-148) [extracellular region] (R-HSA-1233234)	0.609	3
UniProt:Q9BXW9 FANCD2	3	MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522)	0.604	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.599	4
UniProt:Q86VI4 LAP4B			0.599	10
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	6
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.592	2
UniProt:P14174 MIF	3	MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289) MIF [secretory granule lumen] (R-HSA-6803282)	0.591	3
UniProt:Q8IZW8 TNS4	1	TNS4 [cytosol] (R-HSA-201624)	0.59	2
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164)	0.583	4
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.583	3
UniProt:P29353-7 SHC1			0.581	4
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.577	5
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.576	8
UniProt:P23470 PTPRG			0.573	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.571	3
UniProt:Q9Y6R0 NUMBL			0.571	2
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.571	2
UniProt:P07992 ERCC1	2	ERCC1 [nucleoplasm] (R-HSA-54427) Ub-ERCC1 [nucleoplasm] (R-HSA-5696473)	0.571	21
UniProt:P43405 SYK	6	SYK [cytosol] (R-HSA-58268) p-Y348-SYK [cytosol] (R-HSA-437953) p-6Y-SYK [cytosol] (R-HSA-1861712) SYK [plasma membrane] (R-HSA-139844) p-Y-SYK [plasma membrane] (R-HSA-429432) p-Y-SYK [cytosol] (R-HSA-9705732)	0.571	7
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.571	2
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.569	3
UniProt:P63010 AP2B1	4	AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [cytosol] (R-HSA-182166) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [endolysosome membrane] (R-HSA-6784827)	0.569	5
UniProt:P53680 AP2S1	4	AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.569	3
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155) AP2A2(1-939) [plasma membrane] (R-HSA-177502)	0.569	4
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.569	3
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.564	5
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.564	2
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:Q8IZV2 CKLF8			0.556	3
UniProt:O75674 TM1L1			0.556	6
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.553	2
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698)	0.553	2
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.553	2
UniProt:P05107 ITGB2	4	ITGB2 [plasma membrane] (R-HSA-198010) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310)	0.553	2
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.553	2
UniProt:P40925 MDH1	1	MDH1 [cytosol] (R-HSA-198471)	0.553	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.553	2
UniProt:O00170 AIP	2	AIP [cytosol] (R-HSA-8936839) AIP [nucleoplasm] (R-HSA-8937156)	0.553	2
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.553	2
UniProt:Q9H299 SH3L3			0.553	2
UniProt:Q8N111 CEND			0.553	2
UniProt:Q59GR8 Q59GR8			0.553	2
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.553	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.553	2
UniProt:P16930 FAH	1	FAH [cytosol] (R-HSA-71174)	0.553	2
UniProt:Q59G22 Q59G22			0.553	2
UniProt:Q13491 GPM6B			0.553	2
UniProt:A4FU49 SH321			0.553	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.553	2
UniProt:O95433 AHSA1			0.553	2
UniProt:P30307 CDC25C	8	p-S198-CDC25C [nucleoplasm] (R-HSA-156668) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [nucleoplasm] (R-HSA-69741) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)	0.553	2
UniProt:Q7L273 KCTD9			0.553	2
UniProt:Q4KWH8 PLCH1	1	PLCH1 [plasma membrane] (R-HSA-2023859)	0.553	2
UniProt:O15511 ARPC5	4	ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [cytosol] (R-HSA-200806)	0.553	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.553	2
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.553	2
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.553	2
UniProt:P06132 UROD	1	UROD [cytosol] (R-HSA-189427)	0.553	2
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [extracellular region] (R-HSA-349735) ALDOA [cytosol] (R-HSA-71492) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [tertiary granule lumen] (R-HSA-6801485)	0.553	2
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.553	2
UniProt:Q8TDI0 CHD5			0.553	2
UniProt:Q8N2Y8 RUSC2			0.553	2
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.553	2
UniProt:Q53GZ6 Q53GZ6			0.553	2
UniProt:P17600 SYN1	2	SYN1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659624) SYN1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-380577)	0.553	2
UniProt:P31939 ATIC	5	ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710833) ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710847) ATIC(1-230)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710832) ATIC(1-229)-ALK(1058-1620) fusion [cytosol] (R-HSA-9710829) ATIC [cytosol] (R-HSA-62506)	0.553	2
UniProt:Q08881 ITK	3	ITK [cytosol] (R-HSA-202319) p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)	0.553	2
UniProt:P54368 OAZ1	1	OAZ1 [cytosol] (R-HSA-350587)	0.553	2
UniProt:P20336 RAB3A	9	RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512) RAB3A [plasma membrane] (R-HSA-210461) RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743) RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466) RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365) RAB3A [secretory granule membrane] (R-HSA-6804968) RAB3A [cytosol] (R-HSA-8870410) GGC-RAB3A [cytosol] (R-HSA-8870429) GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)	0.553	2
UniProt:Q9NNZ3 DNJC4			0.553	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.553	2
UniProt:Q14050 COL9A3	20	GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179198) GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179194) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179210) 3x4Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179209) 3Hyp-4Hyp-COL9A3 [extracellular region] (R-HSA-2193009) GalHyl-COL9A3 [extracellular region] (R-HSA-2192976) 3x4Hyp-COL9A3 [extracellular region] (R-HSA-2192931) COL9A3 [extracellular region] (R-HSA-375063) 3x4Hyp-3Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2192946) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192978) GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192962) 3x4Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193029) 3x4Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192981) 3x4Hyp-3Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193030) 3x4Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2193003) 5Hyl-COL9A3 [extracellular region] (R-HSA-2193022) 3x4Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470434) 3x4Hyp-3Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470413) 3x4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470381) GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470412)	0.553	2
UniProt:O94992 HEXI1			0.553	2
UniProt:Q96AD5 PNPLA2	4	PNPLA2 [lipid droplet] (R-HSA-9859603) p-PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956923) PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956776) PNPLA2 [endoplasmic reticulum membrane] (R-HSA-1498814)	0.553	2
UniProt:Q9Y3A3 PHOCN			0.553	2
UniProt:O94875 SRBS2			0.553	2
UniProt:Q15819 UBE2V2	2	UBE2V2 [cytosol] (R-HSA-947624) UBE2V2 [nucleoplasm] (R-HSA-5682543)	0.553	2
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.553	2
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141)	0.553	2
UniProt:Q6UWJ1 TMCO3			0.553	2
UniProt:Q99784 NOE1			0.553	2
UniProt:Q92918 M4K1			0.553	2
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.553	2
UniProt:P49798 RGS4	1	RGS4 [plasma membrane] (R-HSA-921135)	0.553	2
UniProt:O75095 MEGF6			0.553	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.553	2
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.553	2
UniProt:Q8N5H7 SH2D3			0.553	2
UniProt:P11309 PIM1	1	PIM1 [nucleoplasm] (R-HSA-3215094)	0.553	2
UniProt:Q02297 NRG1	1	NRG1 [extracellular region] (R-HSA-1227951)	0.553	2
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.553	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.553	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.553	2
UniProt:Q92733 PRCC	1	PRCC [nucleoplasm] (R-HSA-8867896)	0.553	2
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.553	2
UniProt:Q59EJ3 Q59EJ3			0.553	2
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.553	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.553	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.553	2
UniProt:P43243 MATR3			0.553	2
UniProt:P49908 SELENOP	2	SEPP1 [extracellular region] (R-HSA-8848887) SEPP1 [platelet dense granule lumen] (R-HSA-8848897)	0.553	2
UniProt:Q8TDB4 HUMMR			0.553	2
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.553	2
UniProt:Q9Y237 PIN4			0.553	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.553	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.553	2
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [azurophil granule lumen] (R-HSA-6799142) FRK [extracellular region] (R-HSA-6806235) FRK [specific granule lumen] (R-HSA-6801037)	0.553	2
UniProt:P60880 SNAP25	7	SNAP25 [plasma membrane] (R-HSA-2029017) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-197) [plasma membrane] (R-HSA-3004546)	0.553	2
UniProt:P15498 VAV1	5	VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.553	2
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.553	2
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.553	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.553	2
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.553	2
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.553	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.553	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.553	2
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.553	2
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.553	2
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.553	2
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.553	2
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.553	2
UniProt:Q02246 CNTN2	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.553	2
UniProt:P21291 CSRP1	1	CSRP1 [nucleoplasm] (R-HSA-5660398)	0.553	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.553	2
UniProt:Q99704 DOK1	2	p-Y362-DOK1 [cytosol] (R-HSA-8848784) DOK1 [cytosol] (R-HSA-74763)	0.553	2
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.553	2
UniProt:Q9H6Q3 SLA2	1	SLA2 [cytosol] (R-HSA-9706161)	0.553	2
UniProt:P07949 RET	2	p-5Y-RET [plasma membrane] (R-HSA-8854162) RET [plasma membrane] (R-HSA-8853797)	0.553	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.553	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.553	2
UniProt:P23468 PTPRD	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.547	2
UniProt:P10586 PTPRF	2	PTPRF [endosome membrane] (R-HSA-9815889) PTPRF [plasma membrane] (R-HSA-6786486)	0.547	2
UniProt:P29350 PTPN6	5	PTPN6 [cytosol] (R-HSA-197938) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952)	0.547	2
UniProt:Q14956-1 GPNMB			0.544	2
UniProt:P07948-1 LYN			0.544	2
UniProt:Q38SD2 LRRK1			0.544	2
UniProt:P17936 IGFBP3	15	IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454)	0.539	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.537	4
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.536	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.536	3
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	2
UniProt:P55060 XPO2			0.527	2
UniProt:Q6XE38 SG1D4			0.527	2
UniProt:O43592 XPOT	2	XPOT [cytosol] (R-HSA-6783484) XPOT [nucleoplasm] (R-HSA-6783465)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	5
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	2
UniProt:Q00325 S25A3			0.527	3
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	2
UniProt:O00483 NDUFA4	1	NDUFA4 [mitochondrial inner membrane] (R-HSA-60617)	0.527	2
UniProt:Q9H0D6 XRN2	2	XRN2 [nucleoplasm] (R-HSA-6791205) XRN2 [cytosol] (R-HSA-391297)	0.527	5
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	3
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.527	3
UniProt:Q8WXA2 PATE1			0.527	2
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.527	2
UniProt:P62161 CALM			0.524	6
UniProt:P03372-4 ESR1	4	ER alpha36 [cytosol] (R-HSA-9020981) PalmS-ER alpha36 [cytosol] (R-HSA-9020988) PalmS-ER alpha36 [plasma membrane] (R-HSA-9021053) Me87-PalmS-ER alpha36 [plasma membrane] (R-HSA-9637786)	0.524	4
UniProt:Q14956 GPNMB	2	p-Y525-GPNMB [plasma membrane] (R-HSA-8857558) GPNMB [plasma membrane] (R-HSA-8857550)	0.524	3
UniProt:P13866 SLC5A1	8	SLC5A1 [plasma membrane] (R-HSA-189243) SLC5A1 Y191* [plasma membrane] (R-HSA-5656372) SLC5A1 G100V [plasma membrane] (R-HSA-5656373) SLC5A1 Q457R [plasma membrane] (R-HSA-5656354) SLC5A1 R379* [plasma membrane] (R-HSA-5656370) SLC5A1 D28G [plasma membrane] (R-HSA-5656368) SLC5A1 R135W [plasma membrane] (R-HSA-5656381) SLC5A1 D28N [plasma membrane] (R-HSA-5656362)	0.524	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.524	2
UniProt:Q00597 FANCC	2	FANCC [nucleoplasm] (R-HSA-419530) FANCC [cytosol] (R-HSA-420801)	0.519	2
UniProt:P97313	4	Prkdc [cytosol] (R-MMU-8938766) Prkdc [cytosol] (R-MMU-3134816) phospho-Prkdc [nucleoplasm] (R-MMU-76302) Prkdc [nucleoplasm] (R-MMU-62161)	0.518	4
UniProt:P46108-1 CRK			0.508	3
UniProt:Q8TEY7 USP33	1	USP33 [cytosol] (R-HSA-5696962)	0.508	2
UniProt:Q9BRK4 LZTS2			0.508	2
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.508	2
UniProt:P49418 AMPH	1	AMPH [cytosol] (R-HSA-8867728)	0.508	2
UniProt:Q8WXI2 CNKSR2	1	CNKSR2 [cytosol] (R-HSA-5672632)	0.508	2
UniProt:Q9HD43 PTPRH			0.508	3
UniProt:Q7L591 DOK3	3	DOK3 [secretory granule membrane] (R-HSA-6801402) DOK3 [plasma membrane] (R-HSA-6801572) DOK3 [ficolin-1-rich granule membrane] (R-HSA-6801409)	0.508	2
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.508	3
UniProt:O75563 SKAP2	1	SKAP2 [cytosol] (R-HSA-390927)	0.508	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.499	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.499	2
IntAct:EBI-4399559 UBIQ			0.499	3
UniProt:Q80U62 RUBIC			0.499	2
UniProt:Q9QZC5	1	Grb7 [cytosol] (R-RNO-204819)	0.499	7
UniProt:Q13885 TUBB2A	6	TUBB2A [cytosol] (R-HSA-191699) TUBB2A [axonemal microtubule] (R-HSA-5610431) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) TUBB2A unfolded [cytosol] (R-HSA-392776) TUBB2A folding intermediate [cytosol] (R-HSA-392802)	0.499	2
UniProt:P22682 Cbl	8	Cbl [cytosol] (R-MMU-9680636) p-Y-Cbl [cytosol] (R-MMU-9680645) phospho-Cbl [cytosol] (R-MMU-8875457) phospho-Cbl [plasma membrane] (R-MMU-182923) phospho-Cbl [cytosol] (R-MMU-182940) phospho-Cbl [cytosol] (R-MMU-8848826) phospho-Cbl [cytosol] (R-MMU-912656) Cbl [cytosol] (R-MMU-112199)	0.499	2
UniProt:P47869 GABRA2	1	GABRA2 [plasma membrane] (R-HSA-975254)	0.499	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787)	0.499	8
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.499	2
UniProt:Q99959 PKP2	2	PKP2 [cornified envelope] (R-HSA-8847734) PKP2 [plasma membrane] (R-HSA-6814393)	0.483	3
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.483	3
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.483	2
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.483	2
UniProt:Q8IXB1 DJC10			0.483	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	5
UniProt:P18074 ERCC2	2	ERCC2 [nucleoplasm] (R-HSA-67443) ERCC2 [cytosol] (R-HSA-2564770)	0.483	2
UniProt:P40238 MPL	1	MPL [plasma membrane] (R-HSA-443938)	0.483	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	2
UniProt:O14980 XPO1	2	XPO1 [cytosol] (R-HSA-165539) XPO1 [nucleoplasm] (R-HSA-165529)	0.483	2
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.483	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.483	2
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.483	2
UniProt:Q92598 HSPH1	3	HSPH1 [cytosol] (R-HSA-3299412) HSPH1 [endocytic vesicle lumen] (R-HSA-3221904) HSPH1 [extracellular region] (R-HSA-3221883)	0.471	2
UniProt:P25098 GRK2	4	GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318)	0.463	3
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.463	3
UniProt:Q9Y6Q6-2 TNFRSF11A			0.463	3
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.463	3
UniProt:O94898 LRIG2			0.463	4
UniProt:P0A0I7 AGRA			0.463	2
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.463	3
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.463	2

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