Reactome | EGFRvIII [plasma membrane]

EGFRvIII [plasma membrane]

Stable Identifier

R-HSA-1214162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EGFR V30_R297delinsG mutant, Epidermal Growth Factor Receptor V30_R297delinsG mutant, EGFR Val30_Arg297delinsGly mutant

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Locations in the PathwayBrowser for interactor UniProt:Q15109 AGER

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General

EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRvIII, is found in ~25% high-grade glioblastomas and can also be found in squamous cell carcinoma of the lung. EGFRvIII lacks the ligand biding domain and is constitutively active.

External Reference Information

External Reference

UniProt:P00533 EGFR

Gene Names

EGFR, ERBB, ERBB1, HER1

Chain

signal peptide:1-24, chain:25-1210

Reference Genes

BioGPS Gene:1956 EGFR

COSMIC (genes):EGFR EGFR

CTD Gene:1956 EGFR

dbSNP Gene:1956 EGFR

ENSEMBL:ENSG00000146648 EGFR

ENSEMBL_homo_sapiens_GENE:ENSG00000146648.21 EGFR

HGNC:3236 EGFR

KEGG Gene (Homo sapiens):1956 EGFR

Monarch:1956 EGFR

NCBI Gene:1956 EGFR

OMIM:131550 EGFR

UCSC:P00533 EGFR

Reference Transcript

Other Identifiers

11725102_at

11725103_s_at

11725104_a_at

11733760_a_at

11738815_at

11742247_a_at

11751983_a_at

1537_at

1565483_PM_at

1565483_at

1565484_PM_x_at

1565484_x_at

17046135

1956

201983_PM_s_at

201983_s_at

201984_PM_s_at

201984_s_at

210984_PM_x_at

210984_x_at

211550_PM_at

211550_at

211607_PM_x_at

211607_x_at

224999_PM_at

224999_at

3002641

3002642

3002729

3002731

3002733

3002738

3002741

3002743

3002747

3002749

3002750

3002751

3002753

3002757

3002760

3002761

3002763

3002767

3002769

3002770

3002771

3002775

3002776

3002778

3002779

3002786

3002798

3002800

3002801

3002802

3002806

3002807

3002808

3002811

3002812

3002813

3002814

3002815

3002816

3002817

3002818

3002819

3002820

3002821

3002822

3002823

3002824

3002825

37327_at

48285_at

65700_at

8132860

A_14_P106592

A_23_P215790

A_33_P3351944

A_33_P3351955

GE59632

GO:0000139

GO:0000165

GO:0000166

GO:0000278

GO:0000902

GO:0001503

GO:0001618

GO:0001889

GO:0001892

GO:0001934

GO:0001942

GO:0003013

GO:0003677

GO:0003682

GO:0003690

GO:0003824

GO:0004672

GO:0004709

GO:0004713

GO:0004714

GO:0004888

GO:0005006

GO:0005102

GO:0005178

GO:0005515

GO:0005516

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005925

GO:0006260

GO:0006281

GO:0006351

GO:0006355

GO:0006412

GO:0006468

GO:0006629

GO:0006954

GO:0006979

GO:0007155

GO:0007165

GO:0007166

GO:0007169

GO:0007173

GO:0007202

GO:0007435

GO:0007494

GO:0007611

GO:0007623

GO:0008092

GO:0008283

GO:0008284

GO:0008544

GO:0009925

GO:0009986

GO:0010008

GO:0012501

GO:0014070

GO:0016020

GO:0016101

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019899

GO:0019900

GO:0019901

GO:0019903

GO:0021795

GO:0022008

GO:0022414

GO:0023052

GO:0030054

GO:0030139

GO:0030154

GO:0030163

GO:0030296

GO:0030297

GO:0030307

GO:0030324

GO:0030335

GO:0030669

GO:0031410

GO:0031625

GO:0031901

GO:0031965

GO:0032355

GO:0032587

GO:0032930

GO:0032991

GO:0033138

GO:0033590

GO:0033594

GO:0033993

GO:0034614

GO:0035556

GO:0036211

GO:0038083

GO:0038127

GO:0038134

GO:0042059

GO:0042127

GO:0042177

GO:0042311

GO:0042327

GO:0042698

GO:0042743

GO:0042802

GO:0043066

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043586

GO:0044877

GO:0045121

GO:0045296

GO:0045737

GO:0045739

GO:0045740

GO:0045780

GO:0045893

GO:0045907

GO:0045930

GO:0045944

GO:0046328

GO:0046718

GO:0046777

GO:0048143

GO:0048146

GO:0048408

GO:0048471

GO:0048546

GO:0048661

GO:0048812

GO:0048856

GO:0048870

GO:0050673

GO:0050679

GO:0050730

GO:0050877

GO:0051015

GO:0051117

GO:0051205

GO:0051592

GO:0051896

GO:0051897

GO:0051968

GO:0060089

GO:0060252

GO:0060571

GO:0061024

GO:0061029

GO:0070141

GO:0070257

GO:0070372

GO:0070374

GO:0070435

GO:0071230

GO:0071260

GO:0071276

GO:0071363

GO:0071364

GO:0071392

GO:0071466

GO:0071549

GO:0072659

GO:0090263

GO:0097421

GO:0097489

GO:0097708

GO:0098590

GO:0098609

GO:0098772

GO:0140096

GO:1900020

GO:1900087

GO:1901224

GO:1902722

GO:1902895

GO:1903078

GO:1905208

HMNXSV003006702

HMNXSV003057307

Hs.279898.0.S1_3p_at

Hs.77432.0.S1_3p_a_at

Hs2.367845.1.S1_3p_at

Hs2.367845.1.S1_3p_x_at

ILMN_1696521

ILMN_1728858

ILMN_1755535

ILMN_1798975

PH_hs_0004462

PH_hs_0014421

TC07000328.hg

TC07002321.hg

TC07002322.hg

X00588_at

g12002211_3p_at

g1628549_3p_s_at

g4885198_3p_a_at

p26428

Participates

as an input of

EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 (Homo sapiens)

as a component of

EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]

p-5Y-EGFRvIII [plasma membrane]

p-6Y-EGFR E746_A750del;T790M [plasma membrane]

p-6Y-EGFR L858R;T790M [plasma membrane]

p-6Y-EGFR A767_V769dup [plasma membrane]

p-6Y-EGFR N771_H773dup [plasma membrane]

p-6Y-EGFR K739_I744dup [plasma membrane]

p-6Y-EGFR D770_N771insNPG [plasma membrane]

p-6Y-EGFR E746_A750del [plasma membrane]

p-6Y-EGFR L858R [plasma membrane]

p-6Y-EGFR G719S [plasma membrane]

p-6Y-EGFR L747_P753delinsS [plasma membrane]

p-6Y-EGFR L747_A750delinsP [plasma membrane]

p-6Y-EGFR L747_T751del [plasma membrane]

p-6Y-EGFR L747_S752del [plasma membrane]

p-6Y-EGFR L747_T751delinsP [plasma membrane]

p-6Y-EGFR E746_T751delinsA [plasma membrane]

p-6Y-EGFR E746_S752delinsV [plasma membrane]

p-6Y-EGFR L861Q [plasma membrane]

p-6Y-EGFR A289V [plasma membrane]

p-6Y-EGFR T263P [plasma membrane]

p-6Y-EGFR G598V [plasma membrane]

p-6Y-EGFR R108K [plasma membrane]

p-6Y-EGFR A289T [plasma membrane]

p-6Y-EGFR G719C [plasma membrane]

p-6Y-EGFR A289D [plasma membrane]

p-6Y-EGFR G719A [plasma membrane]

EGFR L858R;T790M [plasma membrane]

EGFR E746_A750del;T790M [plasma membrane]

EGFR D770_N771insNPG [plasma membrane]

EGFR K739_I744dup [plasma membrane]

EGFR A767_V769dup [plasma membrane]

EGFR N771_H773dup [plasma membrane]

EGFR L858R [plasma membrane]

EGFR G719S [plasma membrane]

EGFR E746_A750del [plasma membrane]

EGFR L747_P753delinsS [plasma membrane]

EGFR A289V [plasma membrane]

EGFR L747_T751delinsP [plasma membrane]

EGFR L747_T751del [plasma membrane]

EGFR A289D [plasma membrane]

EGFR L861Q [plasma membrane]

EGFR R108K [plasma membrane]

EGFR L747_A750delinsP [plasma membrane]

EGFR E746_T751delinsA [plasma membrane]

EGFR G719A [plasma membrane]

EGFR A289T [plasma membrane]

EGFR E746_S752delinsV [plasma membrane]

EGFR G719C [plasma membrane]

EGFR T263P [plasma membrane]

EGFR G598V [plasma membrane]

EGFR L747_S752del [plasma membrane]

EGFR [endosome membrane]

p-4Y-EGFR [plasma membrane]

p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]

EGFR [plasma membrane]

p-Y1086,Y1101-EGFR [plasma membrane]

p-6Y-EGFR [plasma membrane]

Modified Residues

Name

Deletion of residues 30 to 296

Name

L-arginine 297 replaced with glycine

Coordinate

297

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
brain glioma	DOID:0060108
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
lung squamous cell carcinoma	DOID:3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
astrocytoma	DOID:3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma

Cross References

RefSeq

NP_958441.1, NP_958440.1, NP_958439.1, NP_005219.2

ZINC - World Drugs

EGFR_HUMAN

Guide to Pharmacology - Targets

1797

OpenTargets

ENSG00000146648

ZINC - FDA approved

EGFR_HUMAN

ZINC - Substances

EGFR_HUMAN

ZINC - Biogenic

EGFR_HUMAN

ZINC target

P00533

PRO

P00533

PDB

6TG0, 8HV5, 4KRL, 2M0B, 4G5J, 4TKS, 5UGC, 2RGP, 4KRO, 2N5S, 6Z4B, 3VRP, 7LGS, 8A2A, 5ZTO, 3VRR, 4JR3, 7JXK, 5CZH, 1IVO, 5CZI, 8GB4, 8HGO, 7SZ7, 7VRE, 7LG8, 2ITP, 8TJL, 4JQ7, 6JX0, 8A27, 5JEB, 8DSW, 4RJ7, 8F1W, 7UKW, 6B3S, 8HV6, 4RJ8, 3LZB, 3W2P, 5CAL, 2ITX, 5Y25, 5J9Y, 5WB8, 5GNK, 2ITW, 6V6O, 5CAN, 8HGS, 3P0Y, 8A2B, 4WD5, 3NJP, 6S9D, 6TFZ, 7JXL, 6ARU, 8HGP, 1M14, 4RIW, 7A6I, 6JXT, 5GTZ, 6S8A, 4RIY, 5GMP, 4RJ5, 7ZYM, 5WB7, 2ITO, 2RFE, 2ITZ, 8F1X, 6TFY, 4JQ8, 7LFR, 4ZJV, 2JIU, 4KRM, 7OXB, 5HIB, 4KRP, 7SI1, 2RF9, 5C8K, 5CNN, 7U99, 5XGM, 6S89, 8H7X, 8HV4, 4LI5, 5XDK, 5C8M, 5UG9, 5CNO, 4I21, 5HG8, 4I1Z, 5EM6, 4R3P, 5X2F, 7B85, 5C8N, 4ZAU, 3OB2, 4I23, 7ZYQ, 5EM7, 6JRJ, 6TFU, 2JIV, 8EME, 5ZWJ, 7SZ1, 6P1D, 7LEN, 2RFD, 7U9A, 6S9B, 6TFW, 3OP0, 5UGB, 8WD4, 7UKV, 6JZ0, 7LFS, 7JXI, 6V66, 2ITV, 3QWQ, 5HIC, 6JRX, 5FED, 4HJO, 6V5P, 5EM5, 7OM4, 2EB3, 4LRM, 2KS1, 5GTY, 2EB2, 1YY9, 6JX4, 6LUB, 5UGA, 5X2K, 1Z9I, 7VRA, 5XDL, 7SZ5, 5HG9, 5Y9T, 7SYE, 2JIT, 5CAU, 6V5N, 4UV7, 4UIP, 8HY7, 7AEI, 8D73, 6JRK, 6P1L, 6TFV, 5CAV, 3VJN, 5HG5, 3GT8, 3W2S, 5YU9, 3GOP, 4I20, 7K1I, 6VHN, 2J6M, 2ITU, 5X27, 5FEE, 4I22, 5HCY, 5XGN, 1NQL, 6P8Q, 8HV1, 3BEL, 4R3R, 4I24, 3BUO, 7JXQ, 5EM8, 7ZYN, 7T4I, 6WAK, 8HV9, 2ITN, 5XWD, 3PFV, 5X2C, 4JRV, 6LUD, 2J5F, 3UG1, 7SZ0, 5X2A, 8HV3, 5UG8, 8F1H, 7U98, 3W33, 7TVD, 8HVA, 6JWL, 7ZYP, 7T4J, 8G63, 8HV2, 5HG7, 6VHP, 4R5S, 3B2V, 7AEM, 5X28, 3G5Y, 7ER2, 2GS7, 8D76, 5HCZ, 7JXW, 2GS6, 3C09, 4LL0, 6S9C, 6VH4, 8FV3, 5SX4, 5LV6, 6D8E, 7JXM, 4G5P, 3W2R, 2J5E, 7A6K, 5EDP, 3VJO, 6WA2, 1MOX, 8A2D, 7SYD, 5CAO, 5EDQ, 5SX5, 8F1Y, 2ITT, 6XL4, 5CAP, 4WRG, 6WXN, 2ITQ, 7A6J, 5CAQ, 7KXZ, 5CAS, 8HV7, 6Z4D, 4LQM, 6V6K, 7A2A, 3B2U, 8FV4, 5UWD, 5J9Z, 2ITY, 3W2Q, 4ZSE, 2GS2, 7JXP, 5U8L, 3UG2, 5X26, 1XKK, 4WKQ, 3W32, 2M20, 3IKA, 6DUK, 6TG1, 3POZ, 5EDR, 7K1H, 8F1Z, 5HCX, 7KY0, 4RJ4, 1M17, 4RIX, 8HV8, 5FEQ, 7LTX, 4RJ6, 5D41, 3W2O, 3G5V

ZINC - Investigational

EGFR_HUMAN

ZINC - Metabolites

EGFR_HUMAN

COSMIC

COSM21351

GeneCards

P00533

HPA

ENSG00000146648-EGFR

Ensembl

ENSP00000345973, ENSP00000275493, ENST00000275493, ENSG00000146648, ENSP00000413843, ENSP00000342376, ENST00000344576, ENST00000420316, ENST00000342916

Pharos - Targets

P00533

ZINC - Predictions - Purchasable

EGFR_HUMAN

Orphanet

15917

HMDB Protein

HMDBP01456

Interactors (324)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.983	59
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.981	29
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.976	44
UniProt:P01133 EGF	5	EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086) Pro-EGF [extracellular region] (R-HSA-54209) Pro-EGF [platelet alpha granule lumen] (R-HSA-139875) EGF [extracellular region] (R-HSA-179863) Pro-EGF [plasma membrane] (R-HSA-179888)	0.973	29
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.964	26
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.954	25
UniProt:P21860 ERBB3			0.919	14
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.919	15
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.9	9
UniProt:Q9UJM3 ERRFI			0.9	15
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.898	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.89	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.854	7
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.85	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.833	9
UniProt:P62158 CALM			0.828	6
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.828	8
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.823	6
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.821	8
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.82	7
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.819	6
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.813	7
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.811	10
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.81	7
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.809	12
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.807	5
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.803	7
UniProt:P20417	2	PTPN1 [cytosol] (R-RNO-210625) PTPN1 [endosome membrane] (R-RNO-9815895)	0.802	11
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.8	8
UniProt:P08107 HSP71			0.799	6
UniProt:Q92625 ANS1A			0.793	7
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.793	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.786	13
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.785	7
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.785	5
UniProt:P01135 TGFA	5	TGFA(24-98) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817) TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841) TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840) TGFA(24-98) [extracellular region] (R-HSA-9624183) TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476)	0.779	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.778	7
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.774	7
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.773	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.772	6
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.772	5
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.76	7
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.76	5
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.749	5
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.745	5
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.745	7
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.745	4
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.745	5
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.743	6
UniProt:P26447 S10A4			0.743	6
UniProt:Q92870 APBB2			0.737	7
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.737	4
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.735	4
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.735	5
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.735	4
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.729	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.721	4
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.713	4
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.713	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.695	4
UniProt:Q13387 JIP2			0.692	5
UniProt:P23467 PTPRB	3	PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032)	0.692	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.692	3
UniProt:Q13239 SLA	1	SLA [cytosol] (R-HSA-9706158)	0.692	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.692	4
UniProt:P43403 ZAP70	3	ZAP70 [cytosol] (R-HSA-202397) p-Y493-ZAP70 [cytosol] (R-HSA-202368) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)	0.692	3
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.692	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.692	9
UniProt:Q8TF42 UBS3B			0.69	7
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.683	4
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.683	4
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.683	5
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.681	4
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.681	3
UniProt:O75368 SH3L1			0.681	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.681	4
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-167992)	0.681	3
UniProt:P35221 CTNNA1	2	CTNNA1 [cytosol] (R-HSA-191697) CTNNA1 [plasma membrane] (R-HSA-191735)	0.68	5
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.679	11
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143)	0.671	6
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.669	3
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.669	3
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.668	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.668	3
UniProt:Q09666 AHNK			0.667	4
UniProt:P51636 CAV2	2	CAV2 [plasma membrane] (R-HSA-9021035) CAV2 [Golgi membrane] (R-HSA-9021032)	0.667	3
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.667	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.653	3
UniProt:Q9NZM3 ITSN2	1	ITSN2 [cytosol] (R-HSA-8862264)	0.653	3
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.653	3
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.653	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.653	3
UniProt:Q10567 AP1B1	5	AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [cytosol] (R-HSA-167705)	0.649	4
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.644	13
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.643	5
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.643	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.635	3
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.635	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.635	3
UniProt:Q9Y2H9 MAST1			0.635	3
UniProt:P42229 STAT5A	4	STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.635	4
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.635	4
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.635	3
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116)	0.635	3
UniProt:O43561 LAT	3	p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) p-5Y-LAT [plasma membrane] (R-HSA-202364) LAT [plasma membrane] (R-HSA-202322)	0.635	3
UniProt:Q6S5L8 SHC4			0.635	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.635	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.635	3
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.635	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.635	4
UniProt:Q02952 AKAP12	1	AKAP12 [plasma membrane] (R-HSA-9715082)	0.635	3
UniProt:Q9BRG2 SH23A			0.635	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.635	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.635	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.635	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.635	3
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.628	7
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.623	3
UniProt:Q12852 M3K12			0.621	3
UniProt:Q6UW88 EPGN	2	EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628815) EPGN(23-154) [extracellular region] (R-HSA-9624187)	0.618	3
UniProt:O14944 EREG	2	EREG(60-108) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628816) EREG(60-108) [extracellular region] (R-HSA-1233233)	0.618	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.615	3
UniProt:Q99075 HBEGF	8	HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819) HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776) HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(63-148) [extracellular region] (R-HSA-1233234)	0.609	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.599	4
UniProt:Q86VI4 LAP4B			0.599	10
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	6
UniProt:P08575 PTPRC	2	PTPRC [secretory granule membrane] (R-HSA-6806150) PTPRC [plasma membrane] (R-HSA-197931)	0.592	2
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.591	3
UniProt:Q8IZW8 TNS4	1	TNS4 [cytosol] (R-HSA-201624)	0.59	2
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.583	3
UniProt:P07355 ANXA2	6	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) p-S26-ANXA2 [cytosol] (R-HSA-9865163) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.583	4
UniProt:P29353-7 SHC1			0.581	4
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.581	4
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.576	8
UniProt:P23470 PTPRG			0.573	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.571	3
UniProt:Q9Y6R0 NUMBL			0.571	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.571	2
UniProt:P07992 ERCC1	2	Ub-ERCC1 [nucleoplasm] (R-HSA-5696473) ERCC1 [nucleoplasm] (R-HSA-54427)	0.571	21
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.569	5
UniProt:P53680 AP2S1	4	AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.569	3
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.569	4
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.569	3
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.569	3
UniProt:Q92622 RUBIC			0.564	3
UniProt:Q15303 ERBB4			0.564	3
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.564	2
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.564	5
UniProt:Q8IZV2 CKLF8			0.556	3
UniProt:O75674 TM1L1			0.556	6
UniProt:P60880 SNAP25	7	SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [plasma membrane] (R-HSA-2029017)	0.553	2
UniProt:Q99952 PTPN18	2	PTPN18 [nucleoplasm] (R-HSA-9008900) PTPN18 [cytosol] (R-HSA-8864101)	0.553	2
UniProt:Q02246 CNTN2	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.553	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.553	2
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.553	2
UniProt:P05107 ITGB2	4	ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [plasma membrane] (R-HSA-198010)	0.553	2
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.553	2
UniProt:P40925 MDH1	1	MDH1 [cytosol] (R-HSA-198471)	0.553	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.553	2
UniProt:O00170 AIP	2	AIP [cytosol] (R-HSA-8936839) AIP [nucleoplasm] (R-HSA-8937156)	0.553	2
UniProt:Q9H299 SH3L3			0.553	2
UniProt:Q8N111 CEND			0.553	2
UniProt:Q59GR8 Q59GR8			0.553	2
UniProt:P16152 CBR1	1	CBR1 [cytosol] (R-HSA-2142784)	0.553	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [cytosol] (R-HSA-380285)	0.553	2
UniProt:Q99704 DOK1	2	p-Y362-DOK1 [cytosol] (R-HSA-8848784) DOK1 [cytosol] (R-HSA-74763)	0.553	2
UniProt:P16930 FAH	1	FAH [cytosol] (R-HSA-71174)	0.553	2
UniProt:Q59G22 Q59G22			0.553	2
UniProt:Q13491 GPM6B			0.553	2
UniProt:A4FU49 SH321			0.553	2
UniProt:P21291 CSRP1	1	CSRP1 [nucleoplasm] (R-HSA-5660398)	0.553	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.553	2
UniProt:O95433 AHSA1			0.553	2
UniProt:Q06830 PRDX1	3	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198)	0.553	2
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.553	2
UniProt:Q7L273 KCTD9			0.553	2
UniProt:Q4KWH8 PLCH1	1	PLCH1 [plasma membrane] (R-HSA-2023859)	0.553	2
UniProt:O15511 ARPC5	4	ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [cytosol] (R-HSA-200806)	0.553	2
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.553	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.553	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.553	2
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.553	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.553	2
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.553	2
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.553	2
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.553	2
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.553	2
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.553	2
UniProt:P06132 UROD	1	UROD [cytosol] (R-HSA-189427)	0.553	2
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [extracellular region] (R-HSA-349735) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [cytosol] (R-HSA-71492)	0.553	2
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.553	2
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.553	2
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.553	2
UniProt:Q8TDI0 CHD5			0.553	2
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.553	2
UniProt:Q8N2Y8 RUSC2			0.553	2
UniProt:P42685 FRK	4	FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142) p-Y387-FRK [cytosol] (R-HSA-8847965)	0.553	2
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.553	2
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.553	2
UniProt:Q53GZ6 Q53GZ6			0.553	2
UniProt:P17600 SYN1	2	SYN1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659624) SYN1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-380577)	0.553	2
UniProt:P31939 ATIC	5	ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710833) ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710847) ATIC(1-230)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710832) ATIC(1-229)-ALK(1058-1620) fusion [cytosol] (R-HSA-9710829) ATIC [cytosol] (R-HSA-62506)	0.553	2
UniProt:P54368 OAZ1	1	OAZ1 [cytosol] (R-HSA-350587)	0.553	2
UniProt:Q9UPY6 WASF3	3	WASF3 [cytosol] (R-HSA-200975) p-Y151,S,T-WASF3 [cytosol] (R-HSA-5672385) p-Y151-WASF3 [cytosol] (R-HSA-2029006)	0.553	2
UniProt:P17174 GOT1	1	PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)	0.553	2
UniProt:Q9NNZ3 DNJC4			0.553	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.553	2
UniProt:Q14050 COL9A3	20	GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179198) GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179194) 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179210) 3x4Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179209) 3x4Hyp-GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179203) 3x4Hyp-3Hyp-GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179201) 3x4Hyp-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179208) 3Hyp-4Hyp-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179192) 3x4Hyp-5Hyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179200) 3x4Hyp-3Hyp-5Hyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179196) COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179193) 3x4Hyp-GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470426) COL9A3(?-684) [extracellular region] (R-HSA-2470427) GlcGalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470430) 3x4Hyp-5Hyl-COL9A3(26-?) [extracellular region] (R-HSA-2470398) 3x4Hyp-3Hyp-5Hyl-COL9A3(?-684) [extracellular region] (R-HSA-2470431) 3x4Hyp-3Hyp-5Hyl-COL9A3(26-?) [extracellular region] (R-HSA-2470397) 3x4Hyp-5Hyl-COL9A3(?-684) [extracellular region] (R-HSA-2470450) 3Hyp-4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470384) 3x4Hyp-3Hyp-GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470416)	0.553	2
UniProt:O94992 HEXI1			0.553	2
UniProt:Q9Y3A3 PHOCN			0.553	2
UniProt:Q96AD5 PNPLA2	4	PNPLA2 [lipid droplet] (R-HSA-9859603) p-PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956923) PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956776) PNPLA2 [endoplasmic reticulum membrane] (R-HSA-1498814)	0.553	2
UniProt:O94875 SRBS2			0.553	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.553	2
UniProt:Q15819 UBE2V2	2	UBE2V2 [cytosol] (R-HSA-947624) UBE2V2 [nucleoplasm] (R-HSA-5682543)	0.553	2
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.553	2
UniProt:Q6UWJ1 TMCO3			0.553	2
UniProt:Q99784 NOE1			0.553	2
UniProt:Q92918 M4K1			0.553	2
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.553	2
UniProt:P49798 RGS4	1	RGS4 [plasma membrane] (R-HSA-921135)	0.553	2
UniProt:O75095 MEGF6			0.553	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.553	2
UniProt:O43707 ACTN4	3	ACTN4 [cytosol] (R-HSA-390558) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729)	0.553	2
UniProt:Q8N5H7 SH2D3			0.553	2
UniProt:P11309 PIM1	1	PIM1 [nucleoplasm] (R-HSA-3215094)	0.553	2
UniProt:Q02297 NRG1	1	NRG1 [extracellular region] (R-HSA-1227951)	0.553	2
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.553	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.553	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.553	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.553	2
UniProt:Q92733 PRCC	1	PRCC [nucleoplasm] (R-HSA-8867896)	0.553	2
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.553	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.553	2
UniProt:Q59EJ3 Q59EJ3			0.553	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.553	2
UniProt:P43243 MATR3			0.553	2
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.553	2
UniProt:P49908 SELENOP	2	SEPP1 [extracellular region] (R-HSA-8848887) SEPP1 [platelet dense granule lumen] (R-HSA-8848897)	0.553	2
UniProt:Q8TDB4 HUMMR			0.553	2
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.553	2
UniProt:Q9Y237 PIN4			0.553	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757)