PRDM9 trimethylates histone H3

Stable Identifier
R-HSA-1214188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from experiments in vitro with mouse Prdm9, human PRDM9 methylates histone H3 dimethylated at lysine-4 to yield histone H3 trimethylated at lysine-4.

Literature References
PubMed ID Title Journal Year
16292313 A histone H3 methyltransferase controls epigenetic events required for meiotic prophase

Hayashi, K, Yoshida, K, Matsui, Y

Nature 2005
Participants
Participates
Catalyst Activity

histone methyltransferase activity (H3-K4 specific) of PRDM9:DNA [nucleoplasm]

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