Hydroperoxyl enters the bacterium

Stable Identifier
R-HSA-1222342
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Superoxide can enter the bacterium when acidic conditions apply. Together with a proton it forms the uncharged hydroperoxyl radical (OOH·) which is membrane permeable (Nathan & Shiloh 2000, Zahrt & Deretic 2002, Warner & Mizrahi 2006, Spagnolo et al, 2004).

Literature References
PubMed ID Title Journal Year
16847086 Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy

Warner, DF, Mizrahi, V

Clin Microbiol Rev 2006
11970850 Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis

Zahrt, TC, Deretic, V

Antioxid Redox Signal 2002
15155722 Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site

Spagnolo, L, Törö, I, D'Orazio, M, O'Neill, P, Pedersen, JZ, Carugo, O, Rotilio, G, Battistoni, A, Djinovic-Carugo, K

J Biol Chem 2004
10922044 Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

Nathan, C, Shiloh, MU

Proc Natl Acad Sci U S A 2000
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