Latent infection of Homo sapiens with Mycobacterium tuberculosis

Stable Identifier
R-HSA-1222352
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Infection by Mycobacterium tuberculosis (Mtb) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. A third of the world's population is estimated to harbour latent tuberculosis. Latent infection involves the bacterium being internalized by macrophages and other phagocytes where it stops and counters the innate immune answer (Russell 2011, Russell et al. 2010). When a status-quo is reached, Mtb enters a non-replicating persistent state (Barry et al. 2009, Boshoff & Barry 2005). Another characteristic of Mtb infection is a delayed adaptive immune response for several weeks after infection. This delay is due to prolonged residence of the bacteria in lung phagocytes before dentritic cells can acquire them (Srivastava et al. 2014).

Literature References
PubMed ID Title Journal Year
20466922 Tuberculosis: what we don't know can, and does, hurt us

Russell, DG, Barry CE, 3rd, Flynn, JL

Science 2010
21349098 Mycobacterium tuberculosis and the intimate discourse of a chronic infection

Russell, DG

Immunol Rev 2011
19855401 The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

Barry CE, 3rd, Boshoff, HI, Dartois, V, Dick, T, Ehrt, S, Flynn, J, Schnappinger, D, Wilkinson, RJ, Young, D

Nat Rev Microbiol 2009
15608701 Tuberculosis - metabolism and respiration in the absence of growth

Boshoff, HI, Barry CE, 3rd

Nat Rev Microbiol 2005
25319335 Beyond macrophages: the diversity of mononuclear cells in tuberculosis

Srivastava, S, Ernst, JD, Desvignes, L

Immunol. Rev. 2014
Participants
Participant Of
Event Information
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Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created