NOX2 generates superoxide from oxygen

Stable Identifier
R-HSA-1222376
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Macrophage NOX2 is a membrane complex that generates superoxide anions by reduction of oxygen with NADPH (Babior 1999, Dinauer et al. 1991).

Literature References
PubMed ID Title Journal Year
10029572 NADPH oxidase: an update

Babior, BM

Blood 1999
1763037 Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease

Dinauer, MC, Pierce, EA, Erickson, RW, Muhlebach, TJ, Messner, H, Orkin, SH, Seger, RA, Curnutte, JT

Proc Natl Acad Sci U S A 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
superoxide-generating NADPH oxidase activity of NOX2 complex [phagocytic vesicle membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed