Latent infection - Other responses of Mtb to phagocytosis

Stable Identifier
R-HSA-1222499
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Mtb encounters a vastly changed environment, soon after it gets internalized by macrophages. The compartment it resides in, the phagosome, is acidified and devoid of important metal ions. It is flooded with reactive oxygen and nitrogen species. And steps will be soon taken by the macrophage to "mature" the phagosome with all kinds of lysosomal digestive enzymes. However, unlike most other bacteria species Mtb. has evolved solutions to each of these threats and, after making sure these are installed, it soon will enter a dormant state (de Chastellier, 2009; Flannagan et al, 2009). A combination of the host defense and the response of the infecting bacillus (active and passive) ensure suppression of bacterial metabolic activity and replication, resulting in a non-replicating state (Russell 2011, Russell et al. 2010).

Literature References
PubMed ID Title Journal Year
19369951 Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, RS, Cosio, G, Grinstein, S

Nat Rev Microbiol 2009
19261352 The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages

de Chastellier, C

Immunobiology 2009
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created