Intraphagosomal pH is lowered to 5 by V-ATPase

Stable Identifier
R-HSA-1222516
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The function of V-type proton pumping ATPases is basically the same as that of F-type ATPases, except that V-ATPases cannot synthesize ATP from the proton motive force, the reverse reaction of pumping. When pumping, ATP hydrolysis drives a 120 degree rotation of the rotor which leads to movement of three protons into the phagosome (Adachi et al. 2007).

Literature References
PubMed ID Title Journal Year
17662945 Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation

Adachi, K, Oiwa, K, Nishizaka, T, Furuike, S, Noji, H, Itoh, H, Yoshida, M, Kinosita K, Jr

Cell 2007
Participants
Input
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
proton transmembrane transporter activity of V-ATPase [phagocytic vesicle membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created