Tolerance by Mtb to nitric oxide produced by macrophages

Stable Identifier
R-HSA-1222538
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and Mtb has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages.
Mtb repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004).

Literature References
PubMed ID Title Journal Year
15378046 Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, FC

Nat Rev Microbiol 2004
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created