Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NCF2 [cytosol]
Stable Identifier
R-HSA-1222600
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p67phox
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)
NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)
NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
NOX3 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
PIN1 binds p-S345-NCF1 (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
PKC phosphorylates NCF1 (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
RAC1:GTP binds NOX3 complex (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX3 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
NCF2,NOXA1 [cytosol] (Homo sapiens)
NCF2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19878 NCF2
Gene Names
NCF2, NOXA2, P67PHOX
Chain
chain:1-526
Reference Genes
BioGPS Gene:4688 NCF2
COSMIC (genes):NCF2 NCF2
CTD Gene:4688 NCF2
dbSNP Gene:4688 NCF2
ENSEMBL:ENSG00000116701 NCF2
ENSEMBL_homo_sapiens_GENE:ENSG00000116701.16 NCF2
HGNC:7661 NCF2
KEGG Gene (Homo sapiens):4688 NCF2
Monarch:4688 NCF2
NCBI Gene:4688 NCF2
OMIM:608515 NCF2
UCSC:P19878 NCF2
Reference Transcript
RefSeq:NM_001190789.1 NCF2
RefSeq:NM_001127651.2 NCF2
RefSeq:XM_011509580.1 NCF2
RefSeq:NM_001190794.1 NCF2
RefSeq:XM_011509581.1 NCF2
RefSeq:NM_000433.3 NCF2
Other Identifiers
11741153_a_at
16697095
209949_PM_at
209949_at
2447418
2447419
2447420
2447421
2447422
2447425
2447426
2447427
2447429
2447430
2447431
2447432
2447435
2447439
2447441
2447442
2447443
2447445
2447446
2447447
2447448
41038_at
4688
7922773
A_23_P138194
GE57931
GO:0001669
GO:0002376
GO:0003824
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0006091
GO:0006801
GO:0006909
GO:0006968
GO:0009055
GO:0016020
GO:0016175
GO:0016176
GO:0016192
GO:0016491
GO:0022900
GO:0031267
GO:0031410
GO:0032010
GO:0042554
GO:0043020
GO:0043226
GO:0045087
GO:0045730
GO:0098542
GO:0098772
HMNXSV003013570
ILMN_1796642
M32011_at
PH_hs_0000123
TC01003616.hg
g12804408_3p_at
Participates
as a component of
PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
as a member of
NCF2,NOXA1 [cytosol] (Homo sapiens)
Other forms of this molecule
p-T233-NCF2 [phagolysosome]
Inferred To
NCF2 [cytosol]
(Bos taurus)
NCF2 [cytosol]
(Canis familiaris)
NCF2 [cytosol]
(Gallus gallus)
NCF2 [cytosol]
(Schizosaccharomyces pombe)
NCF2 [cytosol]
(Sus scrofa)
Ncf2 [cytosol]
(Mus musculus)
Ncf2 [cytosol]
(Rattus norvegicus)
Ghost homologue of NCF2 [cytosol]
(Saccharomyces cerevisiae)
ncf2 [cytosol]
(Danio rerio)
ncf2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001121123.1
,
NP_001177723.1
,
NP_001177718.1
,
XP_011507883.1
,
NP_000424.2
,
XP_011507882.1
OpenTargets
ENSG00000116701
GeneCards
P19878
HPA
ENSG00000116701-NCF2
Ensembl
ENSP00000356506
,
ENSP00000399294
,
ENSP00000356505
,
ENST00000418089
,
ENSP00000407217
,
ENST00000367535
,
ENST00000697330
,
ENST00000413720
,
ENSP00000513258
,
ENST00000367536
,
ENSG00000116701
PRO
P19878
Pharos - Targets
P19878
Orphanet
16520
HMDB Protein
HMDBP01614
PDB
1HH8
,
1E96
,
8WEJ
,
1WM5
,
1K4U
,
1OEY
,
2DMO
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92845 KIFAP3
3
KIFAP3 [cytosol]
(R-HSA-984736)
KIFAP3 [cilium]
(R-HSA-5624882)
KIFAP3 [ciliary tip]
(R-HSA-5625382)
0.926
14
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.805
9
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.676
3
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.658
3
UniProt:Q05655 PRKCD
12
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD [cytosol]
(R-HSA-58200)
0.544
3
UniProt:P27870 Vav1
5
p-Y-Vav1 [cytosol]
(R-MMU-9029091)
phospho-Vav1 [plasma membrane]
(R-MMU-389323)
phospho-Vav1 [cytosol]
(R-MMU-437946)
Vav1 [cytosol]
(R-MMU-434625)
Vav1 [plasma membrane]
(R-MMU-1045153)
0.524
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text