AhpD reactivates AhpC

Stable Identifier
R-HSA-1222655
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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AhpD reactivates AhpC
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from lpdC, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).
Literature References
PubMed ID Title Journal Year
21238944 Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes

Bryk, R, Ehrt, S, Rath, P, Venugopal, A, Rhee, K, Shi, S, Nathan, C, Schnappinger, D

Cell Host Microbe 2011
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Catalyst Activity

disulfide oxidoreductase activity of AhpD trimer [cytosol]

Physical Entity
AhpD trimer [cytosol] (Mycobacterium tuberculosis)
Activity
disulfide oxidoreductase activity (GO:0015036)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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