Reactome | CDC37 [cytosol]

CDC37 [cytosol]

Stable Identifier

R-HSA-1225828

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

CDC37 homodimer

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by EGFR in Cancer (Homo sapiens)
    - Signaling by EGFRvIII in Cancer (Homo sapiens)
      - Constitutive Signaling by EGFRvIII (Homo sapiens)
        
        Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)
        
        EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGFRvIII does not bind CBL (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)
        
        EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)
        
        p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)
        
        p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
        
        p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)
        
        EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        EGFRvIII mutant:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
        
        Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
    - Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
      - Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
        
        Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)
        
        Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
        
        Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)
        
        Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Resistant ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Sensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIs [plasma membrane] (Homo sapiens)
        
        Active dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)
        
        Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
        
        Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)
        
        Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
        
        Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
        
        Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
  - Signaling by ERBB2 in Cancer (Homo sapiens)
    - Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
      - ERBB2 binds TKIs (Homo sapiens)
        
        ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 binds trastuzumab (Homo sapiens)
        
        ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 homodimerization (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
        
        ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
    - Drug resistance in ERBB2 KD mutants (Homo sapiens)
      - Resistance of ERBB2 KD mutants to AEE788 (Homo sapiens)
        
        Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)
        
        ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to afatinib (Homo sapiens)
        
        ERBB2 T798M does not bind afatinib (Homo sapiens)
        
        ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to lapatinib (Homo sapiens)
        
        Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)
        
        ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to neratinib (Homo sapiens)
        
        Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)
        
        ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to osimertinib (Homo sapiens)
        
        ERBB2 KD mutants do not bind osimertinib (Homo sapiens)
        
        ERBB2 KD mutants (osimertinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to sapitinib (Homo sapiens)
        
        ERBB2 T862A does not bind sapitinib (Homo sapiens)
        
        ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to tesevatinib (Homo sapiens)
        
        ERBB2 T733I does not bind tesevatinib (Homo sapiens)
        
        ERBB2 T733I:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to trastuzumab (Homo sapiens)
        
        Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)
        
        ERBB2 KD mutants (trastuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
    - Drug resistance in ERBB2 TMD/JMD mutants (Homo sapiens)
      - ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)
        
        ERBB2 TMD/JMD mutants (pertuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
    - Signaling by ERBB2 ECD mutants (Homo sapiens)
      - ERBB2 ECD mutants bind TKIs (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 ECD mutants bind trastuzumab (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
        
        ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
    - Signaling by ERBB2 KD Mutants (Homo sapiens)
      - ERBB2 KD mutants bind TKIs (Homo sapiens)
        
        ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 KD mutants bind trastuzumab (Homo sapiens)
        
        ERBB2 KD mutants (trastuzumab sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 KD mutants heterodimerize (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
        
        ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
    - Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
      - ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)
        
        ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 TMD/JMD mutants (TKI sensitive):TKI:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)
        
        ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 R678Q:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)
        
        ERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
      - ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        CDC37 [cytosol] (Homo sapiens)

Participants

components

x 2 CDC37 [cytosol] (Homo sapiens)

Participates

as a component of

as an input of

as an output of

Inferred To

CDC37 [cytosol] (Bos taurus)

CDC37 [cytosol] (Caenorhabditis elegans)

CDC37 [cytosol] (Canis familiaris)

CDC37 [cytosol] (Danio rerio)

CDC37 [cytosol] (Drosophila melanogaster)

CDC37 [cytosol] (Gallus gallus)

CDC37 [cytosol] (Mus musculus)

CDC37 [cytosol] (Rattus norvegicus)

CDC37 [cytosol] (Saccharomyces cerevisiae)

CDC37 [cytosol] (Schizosaccharomyces pombe)

CDC37 [cytosol] (Sus scrofa)

CDC37 [cytosol] (Xenopus tropicalis)

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