Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1225960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
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EGFR L858R mutant was shown to directly phosphorylate CBL on tyrosine residue Y371. Other EGFR cancer mutants with phosphorylation of tyrosine Y1069 (i.e. Y1045 in the mature protein) are assumed to bind and phosphorylate CBL in a manner similar to the wild-type EGFR.
Literature References
PubMed ID Title Journal Year
16849543 Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors

Qu, S, Perez-Tores, M, Sawai, A, Yang, S, Arteaga, CL, Solit, DB, Rosen, N

Cancer Res 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]

Physical Entity
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)
Functional status

Gain of function of Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-03-03)
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