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p-T401,S672,S1035-RBL2 [nucleoplasm]
Stable Identifier
R-HSA-1226084
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T401,S672,1035-RBL2, p-p130
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)
Ub-p-T401,S672,1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08999 RBL2
Gene Names
RBL2, RB2
Chain
chain:1-1139
Reference Genes
BioGPS Gene:5934 RBL2
COSMIC (genes):RBL2 RBL2
CTD Gene:5934 RBL2
dbSNP Gene:5934 RBL2
ENSEMBL:ENSG00000103479 RBL2
ENSEMBL_homo_sapiens_GENE:ENSG00000103479.17 RBL2
HGNC:9894 RBL2
KEGG Gene (Homo sapiens):5934 RBL2
Monarch:5934 RBL2
NCBI Gene:5934 RBL2
OMIM:180203 RBL2
UCSC:Q08999 RBL2
Reference Transcript
RefSeq:NM_005611.3 RBL2
RefSeq:NM_001323608.1 RBL2
Other Identifiers
11718165_a_at
11718166_a_at
11747866_a_at
11748255_a_at
16818980
1986_at
212331_PM_at
212331_at
212332_PM_at
212332_at
32597_at
3661066
3661067
3661070
3661071
3661073
3661075
3661076
3661077
3661079
3661082
3661083
3661084
3661085
3661087
3661089
3661090
3661092
3661093
3661094
3661096
3661098
3661099
3661100
3661101
3661102
3661107
3661108
3661109
3661110
3661111
5934
7995631
A_14_P123504
A_14_P131886
A_23_P26413
A_24_P416159
GE60009
GO:0000278
GO:0000785
GO:0000977
GO:0003677
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0007049
GO:0010629
GO:0030154
GO:0043226
GO:0043550
GO:0051726
GO:0070062
GO:1990841
GO:2000134
HMNXSV003049133
Hs.79362.0.S1_3p_at
Hs.79362.0.S3_3p_at
ILMN_1756999
PH_hs_0023465
TC16000448.hg
X76061_at
Participates
as an input of
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
as an output of
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
as a component of
Ub-p-T401,S672,1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RBL2 [nucleoplasm]
Inferred To
phospho-Rbl2 [nucleoplasm]
(Mus musculus)
phospho-Rbl2 [nucleoplasm]
(Rattus norvegicus)
phospho-rblA [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm]
(Gallus gallus)
phospho-RBL2 [nucleoplasm]
(Bos taurus)
phospho-RBL2 [nucleoplasm]
(Canis familiaris)
phospho-RBL2 [nucleoplasm]
(Sus scrofa)
phospho-lin-35 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Rbf [nucleoplasm]
(Drosophila melanogaster)
phospho-rbl2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 401
Coordinate
401
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 672
Coordinate
672
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1035
Coordinate
1035
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001310537.1
,
NP_005602.3
OpenTargets
ENSG00000103479
HPA
ENSG00000103479-RBL2
GeneCards
Q08999
Ensembl
ENSG00000103479
,
ENST00000262133
,
ENSP00000262133
PRO
Q08999
Pharos - Targets
Q08999
PDB
4XI9
,
5C1D
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.892
10
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.748
8
UniProt:Q5TKA1 LIN9
1
LIN9 [nucleoplasm]
(R-HSA-389108)
0.702
13
UniProt:Q96GY3 LIN37
1
LIN37 [nucleoplasm]
(R-HSA-389101)
0.702
13
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.69
7
UniProt:P03129 VE7
0.659
3
UniProt:Q6MZP7 LIN54
1
LIN54 [nucleoplasm]
(R-HSA-389103)
0.623
10
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.597
5
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.597
4
UniProt:Q61412 VSX2
0.593
4
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.59
2
UniProt:P24610
1
Pax3 [nucleoplasm]
(R-MMU-5603237)
0.581
3
UniProt:Q52LA3 LIN52
2
p-S28-LIN52 [nucleoplasm]
(R-HSA-1362251)
LIN52 [nucleoplasm]
(R-HSA-389107)
0.558
7
UniProt:Q99708-2 RBBP8
0.556
3
UniProt:I6L8A6 I6L8A6
0.556
3
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.544
2
UniProt:P13631 RARG
1
RARG [nucleoplasm]
(R-HSA-446161)
0.527
2
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.527
2
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.527
3
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.524
2
UniProt:Q13574-2 DGKZ
0.524
2
UniProt:P03255 E1A
0.524
2
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
0.508
2
UniProt:O96020 CCNE2
3
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [cytosol]
(R-HSA-157452)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.462
3
UniProt:Q15329 E2F5
1
E2F5 [nucleoplasm]
(R-HSA-68669)
0.462
4
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.462
4
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