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p-T401,S672,S1035-RBL2 [nucleoplasm]
Stable Identifier
R-HSA-1226084
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T401,S672,1035-RBL2, p-p130
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)
Ub-p-T401,S672,1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
p-T401,S672,S1035-RBL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08999 RBL2
Gene Names
RBL2, RB2
Chain
chain:1-1139
Reference Genes
BioGPS Gene:5934 RBL2
COSMIC (genes):RBL2 RBL2
CTD Gene:5934 RBL2
dbSNP Gene:5934 RBL2
ENSEMBL:ENSG00000103479 RBL2
HGNC:9894 RBL2
KEGG Gene (Homo sapiens):5934 RBL2
Monarch:5934 RBL2
NCBI Gene:5934 RBL2
OMIM:180203 RBL2
UCSC:Q08999 RBL2
Reference Transcript
RefSeq:NM_001323608.1 RBL2
RefSeq:NM_005611.3 RBL2
Other Identifiers
0000450687
11718165_a_at
11718166_a_at
11747866_a_at
11748255_a_at
16547
16818980
19703
1986_at
212331_at
212332_at
32597_at
3661066
3661067
3661070
3661071
3661073
3661075
3661076
3661077
3661079
3661082
3661083
3661084
3661085
3661087
3661089
3661090
3661092
3661093
3661094
3661096
3661098
3661099
3661100
3661101
3661102
3661107
3661108
3661109
3661110
3661111
4XI9
5934
5C1D
7995631
A_14_P123504
A_14_P131886
A_23_P26413
A_24_P416159
AAB29227
AAC50479
AAH34490
AC007342
AK304283
BAH14149
BC034490
CAA52671
CAA53661
CAB016547
CCDS10748
ENSG00000103479
ENSP00000262133
ENST00000262133
ENST00000262133.10
EntrezGene:5934
EntrezGene:RBL2
F5H837
GE60009
GO:0000278
GO:0000785
GO:0001012
GO:0001102
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006325
GO:0006357
GO:0006629
GO:0006950
GO:0006977
GO:0007049
GO:0007165
GO:0007346
GO:0008134
GO:0008150
GO:0009058
GO:0010629
GO:0030154
GO:0032991
GO:0034641
GO:0043226
GO:0043550
GO:0051276
GO:0051301
GO:0051302
GO:0051726
GO:0070062
GO:1990841
GO:2000134
HGNC:9894
HPA019703
Hs.79362.0.S1_3p_at
Hs.79362.0.S3_3p_at
ILMN_1756999
IPR002719
IPR002720
IPR013763
IPR015030
IPR024599
IPR028308
IPR028309
IPR036915
J3KSF7
MIM:180203
NM_001323608
NM_001323609
NM_001323610
NM_001323611
NM_005611
NP_001310537
NP_001310538
NP_001310539
NP_001310540
NP_005602
PF01857
PF01858
PF11934
PH_hs_0023465
RBL2
RBL2-201
S67171
SM00385
SM01367
SM01368
SM01369
TC16000448.hg
U53220
UPI000013D264
X74594
X76061
X76061_at
XM_011523253
XM_017023513
XP_011521555
XP_016879002
Participant Of
input
Dephosphorylation of p130 (RBL2) by PP2A
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
hasComponent
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]
Ub-p-T401,S672,1035-RBL2 [nucleoplasm]
output
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
Other forms of this molecule
RBL2 [nucleoplasm]
Inferred To
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Bos taurus)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Canis familiaris)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Danio rerio)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Dictyostelium discoideum)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Drosophila melanogaster)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Gallus gallus)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Mus musculus)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Rattus norvegicus)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Sus scrofa)
phospho-p-T401,S672,S1035-RBL2 [nucleoplasm] (Xenopus tropicalis)
Homologues of p-T401,S672,S1035-RBL2 [nucleoplasm] (Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 401
Coordinate
401
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 672
Coordinate
672
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1035
Coordinate
1035
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_005602.3
,
NP_001310537.1
OpenTargets
ENSG00000103479
GeneCards
Q08999
PRO
Q08999
PDB
5C1D
,
4XI9
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.812
6
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.748
8
UniProt:P03129 VE7
0.659
3
UniProt:Q6MZP7 LIN54
1
LIN54 [nucleoplasm]
(R-HSA-389103)
0.623
10
UniProt:Q5TKA1 LIN9
1
LIN9 [nucleoplasm]
(R-HSA-389108)
0.612
12
UniProt:Q96GY3 LIN37
1
LIN37 [nucleoplasm]
(R-HSA-389101)
0.612
12
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.597
4
UniProt:Q61412 VSX2
0.593
4
UniProt:P24610
1
PAX3 (1-319) [nucleoplasm]
(R-MMU-5603237)
0.581
3
UniProt:Q52LA3 LIN52
2
p-S28-LIN52 [nucleoplasm]
(R-HSA-1362251)
LIN52 [nucleoplasm]
(R-HSA-389107)
0.558
7
UniProt:I6L8A6 I6L8A6
0.556
3
UniProt:P67775 PPP2CA
4
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
0.544
2
UniProt:Q13574-2 DGKZ
0.524
2
UniProt:P03255 E1A
0.524
2
UniProt:Q923E4 Sirt1
2
SIRT1 [nucleoplasm]
(R-MMU-427531)
Sirt1 [nucleoplasm]
(R-MMU-5211238)
0.524
2
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K432,K526,K604-RBBP8 [nucleoplasm]
(R-HSA-5685955)
0.508
2
UniProt:Q99708-2 RBBP8
0.488
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.462
4
UniProt:O96020 CCNE2
3
CCNE2 [cytosol]
(R-HSA-157452)
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.462
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.462
4
UniProt:Q15329 E2F5
1
E2F5 [nucleoplasm]
(R-HSA-68669)
0.462
4
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.462
3
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