Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex

Stable Identifier
R-HSA-1226094
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

At G1 entry from G0, p130 (RBL2) is phosphorylated on three threonine and serine residues by cyclin D1 dependent kinases CDK4 and/or CDK6, leading to dissociation of p130 (RBL2) from complexes it formed with E2F4 or E2F5 and DP1 or DP2. This is thought to promote translocation of E2F4 and E2F5, which lack nuclear localization signals, to the cytosol, allowing activating E2Fs (E2F1, E2F2 and E2F3) to bind E2F promoters and activate transcription of genes needed for G1 progression.

Literature References
PubMed ID Title Journal Year
9144196 The subcellular localization of E2F-4 is cell-cycle dependent

Lindeman, GJ, Gaubatz, S, Livingston, DM, Ginsberg, D

Proc Natl Acad Sci U S A 1997
11157749 Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block

Hansen, K, Farkas, T, Lukas, J, Holm, K, Rönnstrand, L, Bartek, J

EMBO J 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed