Recruitment of HDAC1 by p130 (RBL2)

Stable Identifier
R-HSA-1227670
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HDAC1 + p130(RBL2):E2F4/5:DP1 => HDAC1-p130(RBL2):E2F4/5:DP1
ReviewStatus
5/5
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Recruitment of HDAC1 by p130 (RBL2)
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p130 (RBL2) in complex with E2F4 or E2F5 and DP1 or DP2 recruits histone deacetylase HDAC1, probably in complex with other chromatin modification factors, and represses transcription of E2F target promoters during G0 in quiescent cells.
Literature References
PubMed ID Title Journal Year
9724731 The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

Robin, P, Harel-Bellan, A, Magnaghi-Jaulin, L, Trouche, D, Ferreira, R

Proc Natl Acad Sci U S A 1998
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Orthologous Events
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Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)
Recruitment of HDAC1 by p130 (RBL2) (Gallus gallus)
Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)
Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)
Recruitment of HDAC1 by p130 (RBL2) (Sus scrofa)
Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-03-10)
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