Reactome | ERBB4 JM-A CYT-1 isoform [plasma membrane]

ERBB4 JM-A CYT-1 isoform [plasma membrane]

Stable Identifier

R-HSA-1227940

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HER4 JM-A-CYT-1 isoform, ERBB4-1, ERBB4 isoform 1

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ERBB2 in Cancer (Homo sapiens)
    - Signaling by ERBB2 KD Mutants (Homo sapiens)
      - ERBB2 KD mutants heterodimerize (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated (EGFR,ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
      - ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
    - Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
      - ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
      - ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15303-1 ERBB4

Gene Names

ERBB4, HER4

Other Identifiers

0002120022

0100580450

11725911_a_at

11725912_a_at

11725913_a_at

16907863

1727_at

2066

206794_at

214053_at

2597563

2597564

2597565

2597566

2597567

2597568

2597569

2597570

2597571

2597580

2597581

2597583

2597584

2597586

2597609

2597615

2597616

2597617

2597621

2597626

2597628

2597629

2597631

2597632

2597633

2597635

2597636

2597637

2597638

2597646

2597661

2597684

2597720

2597788

2597789

37273_at

8058627

92081_at

A_23_P423853

A_32_P183765

A_33_P3211558

GE54083

GE575885

GE79117

GO:0000165

GO:0000166

GO:0000976

GO:0001755

GO:0001934

GO:0003674

GO:0003677

GO:0004672

GO:0004713

GO:0004714

GO:0005154

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006810

GO:0006915

GO:0006950

GO:0007005

GO:0007165

GO:0007169

GO:0007275

GO:0007399

GO:0007416

GO:0007507

GO:0007595

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009058

GO:0009790

GO:0009880

GO:0009925

GO:0014068

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016323

GO:0016477

GO:0016740

GO:0018108

GO:0021551

GO:0021889

GO:0022607

GO:0030154

GO:0030334

GO:0032991

GO:0033674

GO:0034330

GO:0034641

GO:0038128

GO:0040007

GO:0040011

GO:0042531

GO:0042803

GO:0043167

GO:0043226

GO:0043235

GO:0043653

GO:0045165

GO:0045211

GO:0045893

GO:0046427

GO:0046777

GO:0048856

GO:0048870

GO:0051897

GO:0060045

GO:0060644

GO:0060749

GO:0061026

GO:0070374

GO:0071364

GO:0098978

GO:0098982

GO:0099056

GO:0099061

GO:2000010

GO:2000145

GO:2001223

Hs.7888.0.S1_3p_at

ILMN_1653728

ILMN_1661857

L07868_at

PH_hs_0000259

TC02002735.hg

g4885214_3p_at

Participant Of

hasComponent

NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane]

hasMember

ERBB4 CYT-1 isoforms [plasma membrane]

Other forms of this molecule

ERBB4jmAcyt1s80 [mitochondrial matrix]

ERBB4jmAcyt1s80 [nucleoplasm]

ERBB4jmAcyt1ECD [extracellular region]

ERBB4jmAcyt1s80 [cytosol]

ERBB4jmAcyt1m80 [plasma membrane]

p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane]

Inferred To

Egfr [plasma membrane] (Drosophila melanogaster)

Erbb4 [plasma membrane] (Mus musculus)

Erbb4 [plasma membrane] (Rattus norvegicus)

slc6a3 [plasma membrane] (Xenopus tropicalis)

ERBB4 [plasma membrane] (Bos taurus)

ERBB4 [plasma membrane] (Canis familiaris)

ERBB4 [plasma membrane] (Gallus gallus)

ERBB4 [plasma membrane] (Sus scrofa)

let-23 [plasma membrane] (Caenorhabditis elegans)

si:ch73-383l1.1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001036064.1, XP_005246433.1, XP_005246434.1, NP_005226.1

ZINC - World Drugs

ERBB4_HUMAN

OpenTargets

ENSG00000178568

ZINC - FDA approved

ERBB4_HUMAN

ZINC - Substances

ERBB4_HUMAN

ZINC target

Q15303

ZINC - Biogenic

ERBB4_HUMAN

PRO

Q15303

PDB

3BBW, 3U9U, 3U2P, 3BBT, 2R4B, 2L2T, 3U7U, 2LCX, 3BCE, 2AHX

ZINC - Investigational

ERBB4_HUMAN

HPA

ENSG00000178568-ERBB4

GeneCards

Q15303

Ensembl

ENSG00000178568, ENST00000436443, ENST00000342788, ENSP00000403204, ENSP00000342235

ZINC - Predictions - Purchasable

ERBB4_HUMAN

Orphanet

22474

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.778	4
UniProt:P78352 DLG4	3	DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267) DLG4 [plasma membrane] (R-HSA-202135)	0.646	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.609	6
UniProt:Q96JA1 LRIG1	2	LRIG1 [plasma membrane] (R-HSA-197745) Ub-LRIG1 [plasma membrane] (R-HSA-8875434)	0.589	3
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.577	3
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.573	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	7
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [cytosol] (R-HSA-350751) CFL1 [extracellular region] (R-HSA-350747)	0.553	2
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.553	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2