Reactome | ERBB4 JM-A CYT-1 isoform [plasma membrane]

ERBB4 JM-A CYT-1 isoform [plasma membrane]

Stable Identifier

R-HSA-1227940

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HER4 JM-A-CYT-1 isoform, ERBB4-1, ERBB4 isoform 1

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ERBB2 in Cancer (Homo sapiens)
    - Signaling by ERBB2 KD Mutants (Homo sapiens)
      - ERBB2 KD mutants heterodimerize (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated (EGFR,ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
      - ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
    - Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
      - ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
      - ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Homo sapiens)
        
        ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)
        
        ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15303-1 ERBB4

Gene Names

ERBB4, HER4

Participates

as a member of

ERBB4 CYT-1 isoforms [plasma membrane] (Homo sapiens)

as a component of

NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane]

ERBB4jmAcyt1m80 [plasma membrane]

ERBB4jmAcyt1s80 [cytosol]

ERBB4jmAcyt1ECD [extracellular region]

ERBB4jmAcyt1s80 [mitochondrial matrix]

ERBB4jmAcyt1s80 [nucleoplasm]

Inferred To

ERBB4 [plasma membrane] (Canis familiaris)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Bos taurus)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Caenorhabditis elegans)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Danio rerio)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Drosophila melanogaster)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Gallus gallus)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Mus musculus)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Rattus norvegicus)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Sus scrofa)

ERBB4 JM-A CYT-1 isoform [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001036064.1, XP_005246434.1, XP_005246433.1, NP_005226.1

Guide to Pharmacology - Targets

1799

OpenTargets

ENSG00000178568

ENSEMBL

ENST00000260943, ENST00000342788, ENSG00000178568, ENSP00000342235, ENST00000436443, ENSP00000260943, ENSP00000403204

ZINC - FDA approved

ERBB4_HUMAN

ZINC - Substances

ERBB4_HUMAN

ZINC - Biogenic

ERBB4_HUMAN

ZINC target

Q15303

PRO

Q15303

GlyGen

Q15303

PDB

3BBT, 3U7U, 3U2P, 3BBW, 8U4K, 2LCX, 3BCE, 2R4B, 8U4I, 8U4L, 8U4J, 2L2T, 2AHX, 3U9U

ZINC - Investigational

ERBB4_HUMAN

IntEnz

2.7.10.1

HPA

ENSG00000178568-ERBB4

GeneCards

ERBB4

Pharos - Targets

Q15303

Orphanet

ERBB4

ZINC - Predictions - Purchasable

ERBB4_HUMAN

HMDB Protein

HMDBP01376

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.816	5
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.646	6
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.609	6
UniProt:Q96JA1 LRIG1	2	LRIG1 [plasma membrane] (R-HSA-197745) Ub-LRIG1 [plasma membrane] (R-HSA-8875434)	0.589	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.577	3
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.573	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	3
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.553	2
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.553	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.524	2