p-6Y-EGFR E746_T751delinsA [plasma membrane]

Stable Identifier
R-HSA-1228037
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated Epidermal Growth Factor Receptor E746_T751delinsA, p-6Y-EGFR Glu746_Thr751delinsAla
Icon
p-6Y-EGFR E746_T751delinsA [plasma membrane] icon
p-6Y-EGFR E746_T751delinsA [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
15329413 EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

Pao, W, Miller, V, Zakowski, M, Doherty, J, Politi, K, Sarkaria, I, Singh, B, Heelan, R, Rusch, V, Fulton, L, Mardis, E, Kupfer, D, Wilson, R, Kris, M, Varmus, H

Proc Natl Acad Sci U S A 2004
External Reference Information
External Reference
UniProt:P00533 EGFR
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Reference Genes
BioGPS Gene:1956 EGFR
COSMIC (genes):EGFR EGFR
CTD Gene:1956 EGFR
dbSNP Gene:1956 EGFR
ENSEMBL:ENSG00000146648 EGFR
HGNC:3236 EGFR
KEGG Gene (Homo sapiens):1956 EGFR
Monarch:1956 EGFR
NCBI Gene:1956 EGFR
OMIM:131550 EGFR
UCSC:P00533 EGFR
Reference Transcript
Other Identifiers
0000840253
0002940025
0005900148
0006350504
11725102_at
11725103_s_at
11725104_a_at
11733760_a_at
11738815_at
11742247_a_at
11751983_a_at
1537_at
1565483_at
1565484_x_at
17046135
1956
201983_s_at
201984_s_at
210984_x_at
211550_at
211607_x_at
224999_at
3002641
3002642
3002729
3002731
3002733
3002738
3002741
3002743
3002747
3002749
3002750
3002751
3002753
3002757
3002760
3002761
3002763
3002767
3002769
3002770
3002771
3002775
3002776
3002778
3002779
3002786
3002798
3002800
3002801
3002802
3002806
3002807
3002808
3002811
3002812
3002813
3002814
3002815
3002816
3002817
3002818
3002819
3002820
3002821
3002822
3002823
3002824
3002825
37327_at
48285_at
65700_at
8132860
A_14_P106592
A_23_P215790
A_33_P3351944
A_33_P3351955
GE59632
GE85333
GO:0000003
GO:0000139
GO:0000165
GO:0000166
GO:0000186
GO:0000278
GO:0000902
GO:0001503
GO:0001618
GO:0001889
GO:0001892
GO:0001934
GO:0001942
GO:0003013
GO:0003674
GO:0003677
GO:0003682
GO:0003690
GO:0004672
GO:0004709
GO:0004713
GO:0004714
GO:0004888
GO:0005006
GO:0005102
GO:0005178
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005887
GO:0005925
GO:0006259
GO:0006357
GO:0006412
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006950
GO:0006970
GO:0006979
GO:0007049
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007202
GO:0007267
GO:0007275
GO:0007435
GO:0007494
GO:0007611
GO:0007623
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008544
GO:0009056
GO:0009058
GO:0009790
GO:0009925
GO:0009986
GO:0010008
GO:0010750
GO:0010960
GO:0014066
GO:0014070
GO:0015031
GO:0016020
GO:0016021
GO:0016032
GO:0016101
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0019903
GO:0021795
GO:0030054
GO:0030139
GO:0030154
GO:0030234
GO:0030235
GO:0030307
GO:0030324
GO:0030335
GO:0030665
GO:0031410
GO:0031625
GO:0031901
GO:0031965
GO:0032355
GO:0032930
GO:0032991
GO:0033138
GO:0033590
GO:0033594
GO:0033674
GO:0033993
GO:0034614
GO:0034641
GO:0035556
GO:0035690
GO:0038083
GO:0038128
GO:0040007
GO:0040011
GO:0042059
GO:0042060
GO:0042127
GO:0042177
GO:0042327
GO:0042592
GO:0042698
GO:0042743
GO:0042802
GO:0043006
GO:0043066
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043586
GO:0044403
GO:0044877
GO:0045121
GO:0045202
GO:0045296
GO:0045737
GO:0045739
GO:0045740
GO:0045746
GO:0045780
GO:0045893
GO:0045907
GO:0045930
GO:0045944
GO:0046328
GO:0046718
GO:0046777
GO:0048143
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048661
GO:0048812
GO:0048856
GO:0048870
GO:0050679
GO:0050729
GO:0050730
GO:0050877
GO:0050999
GO:0051015
GO:0051117
GO:0051186
GO:0051205
GO:0051592
GO:0051897
GO:0051968
GO:0060571
GO:0061024
GO:0061029
GO:0070141
GO:0070372
GO:0070374
GO:0070435
GO:0071230
GO:0071260
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0071549
GO:0090263
GO:0097421
GO:0097489
GO:0097755
GO:0098609
GO:1900020
GO:1900087
GO:1901185
GO:1901224
GO:1902722
GO:1903078
GO:1903800
GO:1905208
GO:2000145
Hs.279898.0.S1_3p_at
Hs.77432.0.S1_3p_a_at
Hs2.367845.1.S1_3p_at
Hs2.367845.1.S1_3p_x_at
ILMN_1696521
ILMN_1728858
ILMN_1755535
ILMN_1798975
ILMN_1905285
PH_hs_0004462
PH_hs_0014421
TC07000328.hg
TC07002321.hg
TC07002322.hg
X00588_at
g12002211_3p_at
g1628549_3p_s_at
g4885198_3p_a_at
Participant Of
hasCandidate
Other forms of this molecule
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
p-5Y-EGFRvIII [plasma membrane]
EGFRvIII [plasma membrane]
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
p-6Y-EGFR L858R;T790M [plasma membrane]
p-6Y-EGFR M766_A767insASV [plasma membrane]
p-6Y-EGFR D770_N771insNPH [plasma membrane]
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
p-6Y-EGFR D770_N771insNPG [plasma membrane]
p-6Y-EGFR E746_A750del [plasma membrane]
p-6Y-EGFR L858R [plasma membrane]
p-6Y-EGFR G719S [plasma membrane]
p-6Y-EGFR L747_P753delinsS [plasma membrane]
p-6Y-EGFR L747_A750delinsP [plasma membrane]
p-6Y-EGFR L747_T751del [plasma membrane]
p-6Y-EGFR L747_S752del [plasma membrane]
p-6Y-EGFR L747_T751delinsP [plasma membrane]
p-6Y-EGFR E746_S752delinsV [plasma membrane]
p-6Y-EGFR L861Q [plasma membrane]
p-6Y-EGFR A289V [plasma membrane]
p-6Y-EGFR T263P [plasma membrane]
p-6Y-EGFR G598V [plasma membrane]
p-6Y-EGFR R108K [plasma membrane]
p-6Y-EGFR A289T [plasma membrane]
p-6Y-EGFR G719C [plasma membrane]
p-6Y-EGFR A289D [plasma membrane]
p-6Y-EGFR G719A [plasma membrane]
EGFR L858R;T790M [plasma membrane]
EGFR E746_A750del;T790M [plasma membrane]
EGFR D770_N771insNPG [plasma membrane]
EGFR V738_K739insKIPVAI [plasma membrane]
EGFR M766_A767insASV [plasma membrane]
EGFR D770_N771insNPH [plasma membrane]
EGFR L858R [plasma membrane]
EGFR G719S [plasma membrane]
EGFR E746_A750del [plasma membrane]
EGFR L747_P753delinsS [plasma membrane]
EGFR A289V [plasma membrane]
EGFR L747_T751delinsP [plasma membrane]
EGFR L747_T751del [plasma membrane]
EGFR A289D [plasma membrane]
EGFR L861Q [plasma membrane]
EGFR R108K [plasma membrane]
EGFR L747_A750delinsP [plasma membrane]
EGFR E746_T751delinsA [plasma membrane]
EGFR G719A [plasma membrane]
EGFR A289T [plasma membrane]
EGFR E746_S752delinsV [plasma membrane]
EGFR G719C [plasma membrane]
EGFR T263P [plasma membrane]
EGFR G598V [plasma membrane]
EGFR L747_S752del [plasma membrane]
EGFR [endosome membrane]
p-4Y-EGFR [plasma membrane]
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
p-Y1086,Y1101-EGFR [plasma membrane]
EGFR [plasma membrane]
p-6Y-EGFR [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 1045
Coordinate
1045
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1068
Coordinate
1068
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1086
Coordinate
1086
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1148
Coordinate
1148
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1173
Coordinate
1173
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 992
Coordinate
992
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
Replacement of residues 746 to 751 by A
Disease
Name Identifier Synonyms
non-small cell lung carcinoma 3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
6JXT, 5HIB, 5XWD, 6VHN, 2GS6, 3BUO, 3PFV, 3NJP, 4JQ8, 6P1L, 4WD5, 5Y25, 5EDP, 5CZH, 3OB2, 5CNN, 4RJ7, 4I24, 6JRK, 6JZ0, 2ITQ, 4RJ4, 2ITN, 1M14, 4LRM, 5HCY, 1IVO, 1NQL, 4KRP, 5X26, 6V5N, 1Z9I, 4JRV, 5CAS, 5X28, 2RFD, 4HJO, 6S9B, 5GNK, 3B2U, 5CAL, 6JX0, 4G5P, 5JEB, 1MOX, 4RIY, 2N5S, 4LI5, 5J9Y, 5HG9, 4TKS, 2ITX, 5GTY, 5UGC, 5EM6, 4I21, 4KRO, 5SX5, 6VHP, 6V6O, 3G5V, 3UG1, 5XGM, 4RJ5, 3W33, 5WB7, 6S9C, 5CAN, 2ITY, 3W2R, 2JIU, 5C8K, 4G5J, 2EB3, 5X27, 2ITO, 6JRX, 4I1Z, 2ITV, 5C8N, 5CAU, 5X2A, 4KRL, 5ZTO, 2RFE, 4ZSE, 6V5P, 5UWD, 5HG7, 5EDQ, 5UGA, 5FEE, 1XKK, 2EXP, 5XDL, 1DNQ, 5GTZ, 2J5E, 4I22, 5EM7, 4UV7, 5CAP, 2GS2, 5HIC, 3G5Y, 5ZWJ, 5UG8, 1YY9, 6VH4, 3QWQ, 2EXQ, 5WB8, 5FED, 4LQM, 3VJN, 2RF9, 5XDK, 6S9D, 3OP0, 5CAO, 3W2S, 3UG2, 5X2C, 6V66, 4RJ8, 5C8M, 3BEL, 5CNO, 6S89, 5HCZ, 1M17, 5D41, 5J9Z, 3B2V, 4I20, 6B3S, 2ITT, 4ZJV, 3GT8, 3GOP, 5UGB, 6DUK, 3VRP, 2M0B, 5EM5, 5HG8, 4ZAU, 5X2K, 2ITW, 5CAQ, 2GS7, 3LZB, 1DNR, 5FEQ, 3W2P, 5Y9T, 2KS1, 5UG9, 3W2O, 4WKQ, 4LL0, 4JQ7, 6P1D, 2ITP, 5X2F, 2ITZ, 2JIT, 4RJ6, 3POZ, 4RIX, 5HCX, 4WRG, 4JR3, 6JX4, 4I23, 6ARU, 5LV6, 4R3R, 6V6K, 2EB2, 6S8A, 2M20, 5SX4, 4KRM, 5EM8, 5GMP, 3VJO, 2ITU, 3C09, 5U8L, 6JWL, 2J6M, 4R3P, 5CAV, 4R5S, 2JIV, 6D8E, 3P0Y, 5HG5, 3IKA, 6JRJ, 2J5F, 3W32, 2RGP, 4RIW, 5YU9, 3VRR, 5EDR, 5XGN, 6P8Q, 5CZI, 3W2Q, 4UIP
ZINC - Investigational
ZINC - Metabolites
HPA
GeneCards
Ensembl
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (283)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.981 56
 UniProt:P00533 EGFR  59 0.981 29
 UniProt:P29353 SHC1  5 0.973 41
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  6 0.964 26
 UniProt:P04626 ERBB2  117 0.96 25
 UniProt:P40763 STAT3  10 0.924 15
 UniProt:P21860 ERBB3      0.916 13
 UniProt:P12931 SRC  6 0.9 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:P18031 PTPN1  1 0.864 8
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:Q9UJM3 ERRFI      0.826 13
 UniProt:P07948 LYN  5 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P08107 HSP71      0.809 6
 UniProt:Q9UBN7 HDAC6  5 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  1 0.802 11
 UniProt:P16885 PLCG2  10 0.802 6
 UniProt:P08581 MET  7 0.8 8
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P27986 PIK3R1  15 0.779 6
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P07900 HSP90AA1  8 0.778 7
 UniProt:P42224 STAT1  7 0.774 7
 UniProt:Q92569 PIK3R3  2 0.773 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P16333 NCK1  2 0.773 5
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:Q06124 PTPN11  4 0.772 7
 UniProt:P46109 CRKL  2 0.765 5
 UniProt:P0DP25 CALM      0.756 4
 UniProt:P12830 CDH1  10 0.756 4
 UniProt:P38646 HSPA9  6 0.745 5
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:O60716 CTNND1  1 0.745 5
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:Q92625 ANS1A      0.737 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:Q13322 GRB10  1 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q16543 CDC37  1 0.708 11
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P46108 CRK  1 0.692 4
 UniProt:Q13239 SLAP1      0.692 3
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:O00459 PIK3R2  2 0.692 4
 UniProt:P00519 ABL1  5 0.692 3
 UniProt:P51451 BLK  2 0.692 3
 UniProt:P16234 PDGFRA  47 0.683 4
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:O75368 SH3L1      0.681 3
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:P08631 HCK  1 0.681 3
 UniProt:P41240 CSK  2 0.681 3
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:Q9UQC2 GAB2  4 0.669 3
 UniProt:P04792 HSPB1  3 0.669 3
 UniProt:P35221 CTNNA1  2 0.669 4
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q9UQB8 BAIAP2  1 0.667 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:Q96CW1 AP2M1  6 0.667 5
 UniProt:P06493 CDK1  10 0.667 3
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:Q13480 GAB1  4 0.667 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:Q12929 EPS8      0.635 3
 UniProt:P42229 STAT5A  5 0.635 4
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:Q9P0L0 VAPA  4 0.635 3
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:Q02952 AKA12      0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:Q14457 BECN1  3 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q96B97 SH3KBP1  3 0.623 3
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:Q99075 HBEGF  9 0.609 3
 UniProt:O14965 AURKA  6 0.602 4
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P07992 ERCC1  2 0.599 21
 UniProt:Q8TF42 UBS3B      0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:P17936 IGFBP3  15 0.576 3
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:P07947 YES1  2 0.564 3
 UniProt:Q07889 SOS1  3 0.564 2
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:P97313  4 0.556 4
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:Q02246 CNTN2  1 0.553 2
 UniProt:Q05513 PRKCZ  5 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:Q13153 PAK1  6 0.553 2
 UniProt:Q99963 SH3GL3  1 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:P31749 AKT1  13 0.553 2
 UniProt:P16152 CBR1  1 0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q99704 DOK1  2 0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q06830 PRDX1  3 0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:O14544 SOCS6  1 0.553 2
 UniProt:P55036 PSMD4  2 0.553 2
 UniProt:P04049 RAF1  54