Reactome | ARNT [nucleoplasm]

ARNT [nucleoplasm]

Stable Identifier

R-HSA-1234098

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Aryl hydrocarbon receptor nuclear translocator, ARNT_HUMAN, HIF1B, ARNT1

Locations in the PathwayBrowser for interactor UniProt:Q9BQ83 SLX1A

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - NPAS4 regulates expression of target genes (Homo sapiens)
        
        NPAS4 binds ARNT (Homo sapiens)
        
        ARNT [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P27540 ARNT

Gene Names

ARNT, BHLHE2

Chain

initiator methionine:, chain:2-789

Reference Genes

BioGPS Gene:405 ARNT

COSMIC (genes):ARNT ARNT

CTD Gene:405 ARNT

dbSNP Gene:405 ARNT

ENSEMBL:ENSG00000143437 ARNT

ENSEMBL_homo_sapiens_GENE:ENSG00000143437.21 ARNT

HGNC:700 ARNT

KEGG Gene (Homo sapiens):405 ARNT

Monarch:405 ARNT

NCBI Gene:405 ARNT

OMIM:126110 ARNT

UCSC:P27540 ARNT

Reference Transcript

Other Identifiers

11741380_s_at

11741381_a_at

11742052_a_at

11752225_a_at

11757749_s_at

16692857

210828_PM_s_at

210828_s_at

218221_PM_at

218221_at

218222_PM_x_at

218222_x_at

230619_PM_at

230619_at

2434626

2434627

2434628

2434630

2434631

2434632

2434634

2434635

2434637

2434638

2434639

2434640

2434643

2434644

2434645

2434646

2434647

2434648

2434649

2434650

2434654

2434655

2434659

2434660

2434661

2434662

2434663

2434666

2434669

2434673

2434674

2434676

2434678

2434680

2434681

35967_at

35968_s_at

405

52811_at

54673_s_at

7919825

A_23_P550

A_24_P391568

GE58053

GE58942

GE85811

GE86248

GO:0000785

GO:0000978

GO:0000981

GO:0000987

GO:0001666

GO:0001892

GO:0001938

GO:0002376

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0010575

GO:0016604

GO:0017162

GO:0023052

GO:0030154

GO:0030522

GO:0030949

GO:0033235

GO:0034599

GO:0034751

GO:0034753

GO:0036211

GO:0042803

GO:0043226

GO:0043565

GO:0045648

GO:0045821

GO:0045893

GO:0045944

GO:0046886

GO:0046982

GO:0046983

GO:0048856

GO:0050728

GO:0055086

GO:0060089

GO:0061629

GO:0090575

GO:0140110

GO:1901135

GO:1990837

HMNXSV003018847

Hs.166172.0.A2_3p_at

Hs.166172.2.S1_3p_at

ILMN_1762582

ILMN_2347314

M69238_at

PH_hs_0022468

TC01003212.hg

g2702318_3p_a_at

g4502230_3p_a_at

Participates

as a member of

ARNT, ARNT2 [nucleoplasm] (Homo sapiens)

as an input of

as a component of

Inferred To

ARNT [nucleoplasm] (Bos taurus)

ARNT [nucleoplasm] (Canis familiaris)

ARNT [nucleoplasm] (Gallus gallus)

ARNT [nucleoplasm] (Sus scrofa)

Arnt [nucleoplasm] (Mus musculus)

Arnt [nucleoplasm] (Rattus norvegicus)

aha-1 [nucleoplasm] (Caenorhabditis elegans)

tgo [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001659.1, NP_848514.1, NP_001184254.1, XP_016856778.1, NP_001272965.1, NP_001272964.1

OpenTargets

ENSG00000143437

GeneCards

P27540

HPA

ENSG00000143437-ARNT

Ensembl

ENSP00000427571, ENST00000358595, ENST00000515192, ENSP00000423851, ENST00000505755, ENSP00000346372, ENST00000354396, ENSG00000143437, ENSP00000351407

PRO

P27540

Pharos - Targets

P27540

PDB

6D0C, 5TBM, 4H6J, 2A24, 6X37, 6D0B, 3H82, 6X2H, 3F1P, 2HV1, 3H7W, 4PKY, 4XT2, 6D09, 4GS9, 3F1N, 3F1O, 8G4A, 5V0L, 6CZW, 6X28, 4GHI, 1X0O, 4EQ1, 2B02, 8CK8, 8CK3, 8CK4, 4LPZ, 6X3D, 6X21, 2K7S, 5UFP

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.936	13
UniProt:Q99814 EPAS1 (HIF2A)	5	HN-EPAS1 [cytosol] (R-HSA-1234112) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) EPAS1 [nucleoplasm] (R-HSA-452560) EPAS1 [cytosol] (R-HSA-1234119)	0.886	8
UniProt:P35869 AHR	2	AHR [cytosol] (R-HSA-8936842) AHR [nucleoplasm] (R-HSA-8937190)	0.738	7
UniProt:Q6PJQ5 FOXR2			0.643	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:P54687 BCAT1	1	PXLP-BCAT1 [cytosol] (R-HSA-70698)	0.527	2
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2
UniProt:Q9H6Q4 CIAO3	1	NARFL [cytosol] (R-HSA-2564778)	0.527	2
UniProt:Q99742 NPAS1			0.527	3
UniProt:Q9BXJ5 C1QT2			0.527	2
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.499	2
UniProt:Q8NI08 NCOA7			0.499	2