2xHP-HIF1A [nucleoplasm]

Stable Identifier
R-HSA-1234105
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hydroxyPro402,564-HIF1A, HIF1A with hydroxyproline-402 and -564, Hypoxia-inducible factor 1-alpha, HIF1A_HUMAN
Icon
2xHP-HIF1A [nucleoplasm] icon
2xHP-HIF1A [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q16665 HIF1A
Gene Names
HIF1A, BHLHE78, MOP1, PASD8
Chain
chain:1-826
Reference Genes
BioGPS Gene:3091 HIF1A
COSMIC (genes):HIF1A HIF1A
CTD Gene:3091 HIF1A
dbSNP Gene:3091 HIF1A
ENSEMBL:ENSG00000100644 HIF1A
HGNC:4910 HIF1A
KEGG Gene (Homo sapiens):3091 HIF1A
Monarch:3091 HIF1A
NCBI Gene:3091 HIF1A
OMIM:603348 HIF1A
UCSC:Q16665 HIF1A
Reference Transcript
Other Identifiers
0001770044
0002760180
1039_s_at
11718757_s_at
11718758_a_at
11718759_x_at
11747800_a_at
11749123_a_at
11749648_a_at
11749649_x_at
11755737_x_at
16785058
200989_at
3091
3539073
3539074
3539075
3539083
3539084
3539085
3539087
3539088
3539089
3539090
3539091
3539093
3539094
3539095
3539097
3539098
3539099
3539100
3539102
3539103
3539104
3539105
75276_at
7974851
A_14_P117087
A_24_P56388
A_33_P3231277
GE59057
GO:0000003
GO:0000228
GO:0000790
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001525
GO:0001568
GO:0001666
GO:0001755
GO:0001837
GO:0001892
GO:0001922
GO:0001938
GO:0001944
GO:0001947
GO:0002039
GO:0002052
GO:0002248
GO:0002376
GO:0003151
GO:0003208
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005929
GO:0005975
GO:0006089
GO:0006091
GO:0006110
GO:0006355
GO:0006357
GO:0006366
GO:0006464
GO:0006810
GO:0006879
GO:0006914
GO:0006950
GO:0007005
GO:0007165
GO:0007267
GO:0007595
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008542
GO:0009056
GO:0009058
GO:0009790
GO:0010039
GO:0010468
GO:0010508
GO:0010573
GO:0010575
GO:0010628
GO:0010629
GO:0010634
GO:0010870
GO:0014850
GO:0015031
GO:0016239
GO:0016567
GO:0016579
GO:0016604
GO:0016607
GO:0019221
GO:0019896
GO:0019899
GO:0019901
GO:0019904
GO:0021502
GO:0021700
GO:0021987
GO:0030154
GO:0030279
GO:0030502
GO:0030705
GO:0030949
GO:0031514
GO:0031625
GO:0032007
GO:0032364
GO:0032722
GO:0032909
GO:0032963
GO:0032991
GO:0034641
GO:0035035
GO:0035162
GO:0035257
GO:0035774
GO:0040007
GO:0040011
GO:0042127
GO:0042541
GO:0042592
GO:0042593
GO:0042789
GO:0042826
GO:0043066
GO:0043226
GO:0043524
GO:0043536
GO:0043565
GO:0043619
GO:0043687
GO:0044281
GO:0045648
GO:0045766
GO:0045821
GO:0045893
GO:0045926
GO:0045944
GO:0046716
GO:0046886
GO:0046982
GO:0046983
GO:0048514
GO:0048546
GO:0048593
GO:0048646
GO:0048856
GO:0048870
GO:0050790
GO:0050877
GO:0051000
GO:0051216
GO:0051541
GO:0051879
GO:0060574
GO:0061030
GO:0061072
GO:0061298
GO:0061418
GO:0061419
GO:0070101
GO:0070243
GO:0070244
GO:0070888
GO:0071347
GO:0071456
GO:0071542
GO:0090575
GO:0097411
GO:1902895
GO:1903377
GO:1903599
GO:1903715
GO:1904115
GO:2000378
GO:2001054
ILMN_1681283
ILMN_1763260
ILMN_2379788
PH_hs_0028366
TC14002197.hg
U22431_s_at
g4504384_3p_at
Participant Of
output
hasMember
Other forms of this molecule
HN-HIF1A [cytosol]
2xHP-HIF1A [cytosol]
p-Y565,S797-HIF1A [cytosol]
p-Y565-HIF1A [cytosol]
HIF1A [cytosol]
HIF1A [nucleoplasm]
Inferred To
sima [nucleoplasm] (Drosophila melanogaster)
HIF1A [nucleoplasm] (Canis familiaris)
HIF1A [nucleoplasm] (Sus scrofa)
hif1a [nucleoplasm] (Xenopus tropicalis)
hif-1 [nucleoplasm] (Caenorhabditis elegans)
Hif1a [nucleoplasm] (Mus musculus)
Hif1a [nucleoplasm] (Rattus norvegicus)
hif1ab [nucleoplasm] (Danio rerio)
Modified Residues
Name
monohydroxylated proline at 402
Coordinate
402
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 564
Coordinate
564
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Metabolites
GeneCards
HPA
Ensembl
ZINC - Predictions - Purchasable
Orphanet
Interactors (42)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q09472 EP300  5 0.962 20
 UniProt:P40337 VHL  3 0.957 20
 UniProt:P27540 ARNT  1 0.931 12
 UniProt:Q9NWT6 HIF1AN  1 0.922 12
 UniProt:Q9H6Z9 EGLN3  2 0.881 7
 UniProt:Q9GZT9 EGLN1  1 0.803 5
 UniProt:Q15370 ELOB  2 0.789 8
 IntAct:EBI-2895491 VEGFA      0.725 6
 UniProt:Q15369 ELOC  2 0.702 5
 UniProt:P63165 SUMO1  155 0.688 4
 UniProt:Q96KS0 EGLN2  1 0.683 3
 UniProt:O00257 CBX4  2 0.674 15
 UniProt:P41227 NAA10      0.667 3
 UniProt:P40337-3 VHL      0.659 6
 UniProt:Q13438 OS9  1 0.649 9
 UniProt:Q92793 CREBBP  3 0.609 2
 UniProt:P09467 FBP1  1 0.602 5
 UniProt:P14618-1 PKM  1 0.591 7
 UniProt:P17861 XBP1      0.591 3
 UniProt:Q16665 HIF1A  7 0.589 2
 UniProt:P11474 ESRRA  1 0.576 3
 UniProt:P25789 PSMA4  2 0.576 4
 UniProt:MAFG Q9BRP3      0.557 3
 UniProt:Q9UHD8-1 SEPTIN9      0.556 4
 UniProt:Q13330 MTA1  2 0.556 6
 UniProt:O60224 SSX4      0.553 2
 UniProt:O14818 PSMA7  2 0.544 2
 UniProt:Q8BIF2 RFOX3      0.544 2
 UniProt:P40818 USP8  2 0.544 2
 UniProt:P51450-2 Rorc  1 0.544 2
 UniProt:P23771 GATA3  2 0.524 3
 UniProt:P08047 SP1  1 0.524 3
 UniProt:Q92831 KAT2B  1 0.524 2
 UniProt:Q5RIX9  1 0.524 2
 UniProt:Q96CJ1 EAF2  1 0.524 3
 UniProt:Q9C0J9 BHLHE41  1 0.499 2
 UniProt:Q99PV5 Bhlhe41  1 0.499 3
 UniProt:Q61539  1 0.499 2
 UniProt:O94888 UBXN7  1 0.499 3
 UniProt:P46531 NOTCH1  60 0.499 2
 UniProt:P49407 ARRB1  5 0.463 3
 UniProt:P84022 SMAD3  21 0.463 6
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