2xHP-HIF1A [nucleoplasm]

Stable Identifier
R-HSA-1234105
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hydroxyPro402,564-HIF1A, HIF1A with hydroxyproline-402 and -564, Hypoxia-inducible factor 1-alpha, HIF1A_HUMAN
Icon
2xHP-HIF1A [nucleoplasm] icon
2xHP-HIF1A [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q16665 HIF1A
Gene Names
HIF1A, BHLHE78, MOP1, PASD8
Chain
chain:1-826
Reference Genes
BioGPS Gene:3091 HIF1A
COSMIC (genes):HIF1A HIF1A
CTD Gene:3091 HIF1A
dbSNP Gene:3091 HIF1A
ENSEMBL:ENSG00000100644 HIF1A
HGNC:4910 HIF1A
KEGG Gene (Homo sapiens):3091 HIF1A
Monarch:3091 HIF1A
NCBI Gene:3091 HIF1A
OMIM:603348 HIF1A
UCSC:Q16665 HIF1A
Reference Transcript
Other Identifiers
0001770044
0002760180
1039_s_at
11718757_s_at
11718758_a_at
11718759_x_at
11747800_a_at
11749123_a_at
11749648_a_at
11749649_x_at
11755737_x_at
1275
16785058
17442
1D7G
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
200989_at
2ILM
3091
3539073
3539074
3539075
3539083
3539084
3539085
3539087
3539088
3539089
3539090
3539091
3539093
3539094
3539095
3539097
3539098
3539099
3539100
3539102
3539103
3539104
3539105
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
75276_at
7974851
907
A8MYV6
A_14_P117087
A_24_P56388
A_33_P3231277
AAC50152
AAC51210
AAC68568
AAF20139
AAF20140
AAF20149
AAG43026
AAH12527
AAP88778
AB073325
AB500182
ACN88547
AF050115
AF050116
AF050117
AF050118
AF050119
AF050120
AF050121
AF050122
AF050123
AF050124
AF050125
AF050126
AF050127
AF207601
AF207602
AF208487
AF304431
AL137129
BAB70608
BAI49183
BC012527
BT009776
CAB017442
CCDS58324
CCDS9753
CCDS9754
CH471061
D0VY79
EAW80807
EAW80808
ENSG00000100644
ENSP00000323326
ENSP00000338018
ENSP00000437955
ENST00000323441
ENST00000323441.10
ENST00000337138
ENST00000337138.8
ENST00000539097
ENST00000539097.2
EntrezGene:3091
EntrezGene:HIF1A
F8W9L0
FJ790247
g4504384_3p_at
GE59057
GO:0000003
GO:0000228
GO:0000790
GO:0000977
GO:0000981
GO:0001228
GO:0001525
GO:0001568
GO:0001666
GO:0001755
GO:0001837
GO:0001892
GO:0001922
GO:0001938
GO:0001944
GO:0001947
GO:0002039
GO:0002052
GO:0002248
GO:0002376
GO:0003151
GO:0003208
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005929
GO:0005975
GO:0006089
GO:0006091
GO:0006110
GO:0006355
GO:0006357
GO:0006366
GO:0006464
GO:0006810
GO:0006879
GO:0006914
GO:0006950
GO:0007005
GO:0007165
GO:0007267
GO:0007595
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008542
GO:0009056
GO:0009058
GO:0009790
GO:0010039
GO:0010468
GO:0010508
GO:0010573
GO:0010575
GO:0010628
GO:0010629
GO:0010634
GO:0010870
GO:0014850
GO:0015031
GO:0016239
GO:0016567
GO:0016579
GO:0016604
GO:0016607
GO:0019221
GO:0019896
GO:0019899
GO:0019901
GO:0019904
GO:0021502
GO:0021700
GO:0021987
GO:0030154
GO:0030279
GO:0030502
GO:0030705
GO:0030949
GO:0031514
GO:0031625
GO:0032007
GO:0032364
GO:0032722
GO:0032909
GO:0032963
GO:0032991
GO:0034641
GO:0035035
GO:0035162
GO:0035257
GO:0035774
GO:0040007
GO:0040011
GO:0042127
GO:0042541
GO:0042592
GO:0042593
GO:0042789
GO:0042826
GO:0043066
GO:0043226
GO:0043524
GO:0043536
GO:0043565
GO:0043619
GO:0043687
GO:0044281
GO:0045648
GO:0045766
GO:0045821
GO:0045893
GO:0045926
GO:0045944
GO:0046716
GO:0046886
GO:0046982
GO:0046983
GO:0048514
GO:0048546
GO:0048593
GO:0048646
GO:0048856
GO:0048870
GO:0050790
GO:0050877
GO:0051000
GO:0051216
GO:0051541
GO:0051879
GO:0060574
GO:0061030
GO:0061072
GO:0061298
GO:0061418
GO:0061419
GO:0070101
GO:0070243
GO:0070244
GO:0070888
GO:0071347
GO:0071456
GO:0071542
GO:0090575
GO:0097411
GO:1902895
GO:1903377
GO:1903599
GO:1903715
GO:1904115
GO:2000378
GO:2001054
HGNC:4910
HIF1A
HIF1A-201
HIF1A-202
HIF1A-204
HPA000907
HPA001275
ILMN_1681283
ILMN_1763260
ILMN_2379788
IPR000014
IPR001321
IPR001610
IPR011598
IPR013655
IPR013767
IPR014887
IPR021537
IPR035965
IPR036638
MIM:603348
NM_001243084
NM_001530
NM_181054
NP_001230013
NP_001521
NP_851397
PF00989
PF08447
PF08778
PF11413
PH_hs_0028366
PR01080
SM00086
SM00091
SM00353
TC14002197.hg
U22431
U22431_s_at
U29165
UPI0000000A06
UPI0000071E57
UPI0001982748
Participant Of
hasMember
output
Other forms of this molecule
HN-HIF1A [cytosol]
2xHP-HIF1A [cytosol]
p-Y565,S797-HIF1A [cytosol]
p-Y565-HIF1A [cytosol]
HIF1A [cytosol]
HIF1A [nucleoplasm]
Inferred To
2xHP-HIF1A [nucleoplasm] (Caenorhabditis elegans)
2xHP-HIF1A [nucleoplasm] (Canis familiaris)
2xHP-HIF1A [nucleoplasm] (Danio rerio)
2xHP-HIF1A [nucleoplasm] (Drosophila melanogaster)
2xHP-HIF1A [nucleoplasm] (Gallus gallus)
2xHP-HIF1A [nucleoplasm] (Mus musculus)
2xHP-HIF1A [nucleoplasm] (Rattus norvegicus)
2xHP-HIF1A [nucleoplasm] (Sus scrofa)
2xHP-HIF1A [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
monohydroxylated proline at 402
Coordinate
402
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 564
Coordinate
564
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
Orphanet
Interactors (42)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q09472 EP300  5 0.962 20
 UniProt:P40337 VHL  3 0.957 20
 UniProt:P27540 ARNT  1 0.931 12
 UniProt:Q9NWT6 HIF1AN  1 0.922 12
 UniProt:Q9H6Z9 EGLN3  2 0.881 7
 UniProt:Q9GZT9 EGLN1  1 0.803 5
 UniProt:Q15370 ELOB  2 0.789 8
 IntAct:EBI-2895491 VEGFA      0.725 6
 UniProt:Q15369 ELOC  2 0.702 5
 UniProt:P63165 SUMO1  155 0.688 4
 UniProt:Q96KS0 EGLN2  1 0.683 3
 UniProt:O00257 CBX4  2 0.674 15
 UniProt:P41227 NAA10      0.667 3
 UniProt:P40337-3 VHL      0.659 6
 UniProt:Q13438 OS9  1 0.649 9
 UniProt:Q92793 CREBBP  3 0.609 2
 UniProt:P09467 FBP1  1 0.602 5
 UniProt:P14618-1 PKM  1 0.591 7
 UniProt:P17861 XBP1      0.591 3
 UniProt:Q16665 HIF1A  7 0.589 2
 UniProt:P25789 PSMA4  2 0.576 4
 UniProt:P11474 ESRRA  1 0.576 3
 UniProt:MAFG Q9BRP3      0.557 3
 UniProt:Q9UHD8-1 SEPTIN9      0.556 4
 UniProt:Q13330 MTA1  2 0.556 6
 UniProt:O60224 SSX4      0.553 2
 UniProt:O14818 PSMA7  2 0.544 2
 UniProt:P40818 USP8  2 0.544 2
 UniProt:Q8BIF2 RFOX3      0.544 2
 UniProt:P51450-2 Rorc  2 0.544 2
 UniProt:P23771 GATA3  2 0.524 3
 UniProt:Q96CJ1 EAF2  1 0.524 3
 UniProt:Q5RIX9  1 0.524 2
 UniProt:P08047 SP1  1 0.524 3
 UniProt:Q92831 KAT2B  1 0.524 2
 UniProt:P46531 NOTCH1  60 0.499 2
 UniProt:Q9C0J9 BHLHE41  1 0.499 2
 UniProt:Q61539  1 0.499 2
 UniProt:O94888 UBXN7  1 0.499 3
 UniProt:Q99PV5 Bhlhe41  1 0.499 3
 UniProt:P84022 SMAD3  12 0.463 6
 UniProt:P49407 ARRB1  5 0.463 3