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2xHP-HIF1A [nucleoplasm]
Stable Identifier
R-HSA-1234105
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hydroxyPro402,564-HIF1A, HIF1A with hydroxyproline-402 and -564, Hypoxia-inducible factor 1-alpha, HIF1A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)
2xHP-HIF1A [nucleoplasm] (Homo sapiens)
Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
2xHP-HIF1A [nucleoplasm] (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
2xHP-HIF1A [nucleoplasm] (Homo sapiens)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
2xHP-HIF1A [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
2xHP-HIF1A [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
2xHP-HIF1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16665 HIF1A
Gene Names
HIF1A, BHLHE78, MOP1, PASD8
Chain
chain:1-826
Reference Genes
BioGPS Gene:3091 HIF1A
COSMIC (genes):HIF1A HIF1A
CTD Gene:3091 HIF1A
dbSNP Gene:3091 HIF1A
ENSEMBL:ENSG00000100644 HIF1A
HGNC:4910 HIF1A
KEGG Gene (Homo sapiens):3091 HIF1A
Monarch:3091 HIF1A
NCBI Gene:3091 HIF1A
OMIM:603348 HIF1A
UCSC:Q16665 HIF1A
Reference Transcript
RefSeq:NM_181054.2 HIF1A
RefSeq:NM_001243084.1 HIF1A
RefSeq:NM_001530.3 HIF1A
Other Identifiers
0001770044
0002760180
1039_s_at
11718757_s_at
11718758_a_at
11718759_x_at
11747800_a_at
11749123_a_at
11749648_a_at
11749649_x_at
11755737_x_at
16785058
200989_at
3091
3539073
3539074
3539075
3539083
3539084
3539085
3539087
3539088
3539089
3539090
3539091
3539093
3539094
3539095
3539097
3539098
3539099
3539100
3539102
3539103
3539104
3539105
75276_at
7974851
A_14_P117087
A_24_P56388
A_33_P3231277
GE59057
GO:0000003
GO:0000228
GO:0000790
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001525
GO:0001568
GO:0001666
GO:0001755
GO:0001837
GO:0001892
GO:0001922
GO:0001938
GO:0001944
GO:0001947
GO:0002039
GO:0002052
GO:0002248
GO:0002376
GO:0003151
GO:0003208
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005929
GO:0005975
GO:0006089
GO:0006091
GO:0006110
GO:0006355
GO:0006357
GO:0006464
GO:0006810
GO:0006879
GO:0006914
GO:0006950
GO:0007005
GO:0007165
GO:0007267
GO:0007595
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008542
GO:0009056
GO:0009058
GO:0009790
GO:0010039
GO:0010468
GO:0010508
GO:0010573
GO:0010575
GO:0010628
GO:0010629
GO:0010634
GO:0010870
GO:0014850
GO:0015031
GO:0016239
GO:0016567
GO:0016579
GO:0016604
GO:0016607
GO:0019221
GO:0019896
GO:0019899
GO:0019901
GO:0019904
GO:0021502
GO:0021700
GO:0021987
GO:0030154
GO:0030279
GO:0030502
GO:0030705
GO:0030949
GO:0031514
GO:0031625
GO:0032007
GO:0032364
GO:0032722
GO:0032909
GO:0032963
GO:0032991
GO:0034641
GO:0035035
GO:0035162
GO:0035257
GO:0035774
GO:0040007
GO:0040011
GO:0042127
GO:0042541
GO:0042592
GO:0042593
GO:0042826
GO:0043066
GO:0043226
GO:0043524
GO:0043536
GO:0043565
GO:0043619
GO:0043687
GO:0044281
GO:0045648
GO:0045766
GO:0045821
GO:0045893
GO:0045926
GO:0045944
GO:0046716
GO:0046886
GO:0046982
GO:0046983
GO:0048514
GO:0048546
GO:0048593
GO:0048646
GO:0048856
GO:0048870
GO:0050790
GO:0050877
GO:0051000
GO:0051216
GO:0051541
GO:0051879
GO:0060574
GO:0061030
GO:0061072
GO:0061298
GO:0061418
GO:0061419
GO:0070101
GO:0070243
GO:0070244
GO:0070888
GO:0071347
GO:0071456
GO:0071542
GO:0090575
GO:0097411
GO:1902895
GO:1903377
GO:1903599
GO:1903715
GO:1904115
GO:2000378
GO:2001054
ILMN_1681283
ILMN_1763260
ILMN_2379788
PH_hs_0028366
TC14002197.hg
U22431_s_at
g4504384_3p_at
Participant Of
hasMember
hydroxyPro-HIF-alpha [nucleoplasm]
output
Nuclear PHD1,3 hydroxylates proline residues on HIF1A
Other forms of this molecule
2xHP-HIF1A [cytosol]
HN-HIF1A [cytosol]
p-Y565,S797-HIF1A [cytosol]
p-Y565-HIF1A [cytosol]
HIF1A [cytosol]
HIF1A [nucleoplasm]
Inferred To
sima [nucleoplasm] (Drosophila melanogaster)
HIF1A [nucleoplasm] (Canis familiaris)
HIF1A [nucleoplasm] (Sus scrofa)
hif1a [nucleoplasm] (Xenopus tropicalis)
hif-1 [nucleoplasm] (Caenorhabditis elegans)
Hif1a [nucleoplasm] (Mus musculus)
Hif1a [nucleoplasm] (Rattus norvegicus)
hif1ab [nucleoplasm] (Danio rerio)
Modified Residues
Name
monohydroxylated proline at 402
Coordinate
402
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 564
Coordinate
564
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
RefSeq
NP_001521.1
,
NP_851397.1
,
NP_001230013.1
ZINC - World Drugs
HIF1A_HUMAN
OpenTargets
ENSG00000100644
ZINC - FDA approved
HIF1A_HUMAN
ZINC - Substances
HIF1A_HUMAN
ZINC target
Q16665
ZINC - Biogenic
HIF1A_HUMAN
PRO
Q16665
PDB
1L8C
,
5L9V
,
2ILM
,
1H2L
,
3HQR
,
3HQU
,
5L9B
,
6GFX
,
1LQB
,
5JWP
,
6GMR
,
1LM8
,
1D7G
,
1H2M
,
1H2K
,
5LAS
,
4H6J
,
5LA9
,
1L3E
,
4AJY
ZINC - Metabolites
HIF1A_HUMAN
GeneCards
Q16665
HPA
ENSG00000100644-HIF1A
Ensembl
ENST00000539097
,
ENST00000323441
,
ENST00000337138
,
ENSG00000100644
,
ENSP00000338018
,
ENSP00000323326
,
ENSP00000437955
ZINC - Predictions - Purchasable
HIF1A_HUMAN
Orphanet
24596
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09472 EP300
5
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.962
20
UniProt:P40337 VHL
3
VHL [nucleoplasm]
(R-HSA-1234127)
SUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [cytosol]
(R-HSA-391423)
0.957
20
UniProt:P27540 ARNT
1
ARNT [nucleoplasm]
(R-HSA-1234098)
0.931
12
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.922
12
UniProt:Q9H6Z9 EGLN3
2
EGLN3 [nucleoplasm]
(R-HSA-1234104)
EGLN3 [cytosol]
(R-HSA-1234115)
0.881
7
UniProt:Q9GZT9 EGLN1
1
EGLN1 [cytosol]
(R-HSA-1234108)
0.803
5
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.789
8
IntAct:EBI-2895491 VEGFA
0.725
6
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.702
5
UniProt:P63165 SUMO1
155
TOPORS-G97-SUMO1 [nucleoplasm]
(R-HSA-4551623)
K14-UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-4085334)
PIAS4-G97-SUMO1 [nucleoplasm]
(R-HSA-3968375)
K2592-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551627)
K2723-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551737)
K2650-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551591)
K196-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551630)
K171-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551632)
K159-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551713)
MDM-G97-SUMO1 [nucleoplasm]
(R-HSA-3730829)
K575-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090305)
K804-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782561)
K750-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090298)
K676-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090396)
K554-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782555)
K779-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782585)
ING2-G97-SUMO1 [nucleoplasm]
(R-HSA-4086096)
K788-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085297)
K731-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085312)
K239-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085320)
K239-NCOA2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085299)
K731-NCOA2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085290)
K788-NCOA2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085308)
NPM1-G97-SUMO1 [nucleoplasm]
(R-HSA-4086019)
NCOR2-G97-SUMO1 [nucleoplasm]
(R-HSA-3927883)
DDX17-G97-SUMO1 [nucleoplasm]
(R-HSA-3900210)
PARK7-G97-SUMO1 [nucleoplasm]
(R-HSA-4085344)
K1033-CREBBP-G97-SUMO1 [nucleoplasm]
(R-HSA-3927910)
K1056-CREBBP-G97-SUMO1 [nucleoplasm]
(R-HSA-3927954)
K998-CREBBP-G97-SUMO1 [nucleoplasm]
(R-HSA-3927822)
K1154-NRIP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4086067)
K756-NRIP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4086034)
DDX5-G97-SUMO1 [nucleoplasm]
(R-HSA-3900212)
CASP8AP2-G97-SUMO1 [nucleoplasm]
(R-HSA-3927863)
K1024-EP300-G97-SUMO1 [nucleoplasm]
(R-HSA-3899298)
K1020-EP300-G97-SUMO1 [nucleoplasm]
(R-HSA-3899290)
CTBP1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730764)
K231-SAFB-G97-SUMO1 [nucleoplasm]
(R-HSA-4085364)
K294-SAFB-G97-SUMO1 [nucleoplasm]
(R-HSA-4085341)
K624-MKL1-G97-SUMO1 [nucleoplasm]
(R-HSA-3900128)
K576-MKL1-G97-SUMO1 [nucleoplasm]
(R-HSA-3900225)
K499-MKL1-G97-SUMO1 [nucleoplasm]
(R-HSA-3900219)
K631-DAXX-G97-SUMO1 [nucleoplasm]
(R-HSA-4086044)
K630-DAXX-G97-SUMO1 [nucleoplasm]
(R-HSA-4086012)
SIN3A-G97-SUMO1 [nucleoplasm]
(R-HSA-4086058)
PPARGC1A-G97-SUMO1 [nucleoplasm]
(R-HSA-3903014)
HIPK2-G97-SUMO1 [nucleoplasm]
(R-HSA-4090362)
K774-NCOA1-G97-SUMO1 [nucleoplasm]
(R-HSA-4085292)
K732-NCOA1-G97-SUMO1 [nucleoplasm]
(R-HSA-4085278)
K538-MBD1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090416)
K499-MBD1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090332)
ZNF131-G97-SUMO1 [nucleoplasm]
(R-HSA-3730875)
K90-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755511)
K689-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755446)
K863-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755412)
K298-NFKB2-G97-SUMO1 [cytosol]
(R-HSA-4755505)
p-S172-IKBKE-G97-SUMO1 [nucleoplasm]
(R-HSA-4755408)
K309-IKBKG-G97-SUMO1 [nucleoplasm]
(R-HSA-4755404)
K277-IKBKG-G97-SUMO1 [nucleoplasm]
(R-HSA-4755531)
NFKBIA-G97-SUMO1 [nucleoplasm]
(R-HSA-4656987)
AURKA-G97-SUMO1 [cytosol]
(R-HSA-4655413)
TOP2B-G97-SUMO1 [nucleoplasm]
(R-HSA-4641311)
TOP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4641306)
TOP2A-G97-SUMO1 [nucleoplasm]
(R-HSA-4641341)
K254-PCNA-G97-SUMO1 [nucleoplasm]
(R-HSA-4615853)
K-PCNA-G97-SUMO1 [nucleoplasm]
(R-HSA-4615836)
K164-PCNA-G97-SUMO1 [nucleoplasm]
(R-HSA-4615951)
MDC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4570527)
STAG2-G97-SUMO1 [nucleoplasm]
(R-HSA-3826645)
RAD21-G97-SUMO1 [nucleoplasm]
(R-HSA-3826574)
K411-RAD52-G97-SUMO1 [nucleoplasm]
(R-HSA-4568857)
K412-RAD52-G97-SUMO1 [nucleoplasm]
(R-HSA-4568850)
K414-RAD52-G97-SUMO1 [nucleoplasm]
(R-HSA-4568900)
XRCC4-G97-SUMO1 [nucleoplasm]
(R-HSA-4568869)
K160-PML-G97-SUMO1 [nucleoplasm]
(R-HSA-3730884)
K490-PML-G97-SUMO1 [nucleoplasm]
(R-HSA-3730833)
K65-PML-G97-SUMO1 [nucleoplasm]
(R-HSA-3730879)
K203-PARP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4551625)
K486-PARP1-G97-SUMO1 [nucleoplasm]
(R-HSA-4551748)
K496-WRN-G97-SUMO1 [nucleoplasm]
(R-HSA-4568906)
K898-WRN-G97-SUMO1 [nucleoplasm]
(R-HSA-4568893)
K356-WRN-G97-SUMO1 [nucleoplasm]
(R-HSA-4568845)
RNF168-SUMO1 [nucleoplasm]
(R-HSA-4551631)
XPC-G97-SUMO1 [nucleoplasm]
(R-HSA-4570452)
TDG-G97-SUMO1 [nucleoplasm]
(R-HSA-4551682)
SP100-G97-SUMO1 [nucleoplasm]
(R-HSA-3730794)
BRCA1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730735)
RXRA-G97-SUMO1 [nucleoplasm]
(R-HSA-4341090)
NR5A2-G97-SUMO1 [nucleoplasm]
(R-HSA-4755424)
K386-AR-G97-SUMO1 [nucleoplasm]
(R-HSA-4090321)
K520-AR-G97-SUMO1 [nucleoplasm]
(R-HSA-4090352)
K293-NR3C1-G97-SUMO1 [nucleoplasm]
(R-HSA-4341110)
K277-NR3C1-G97-SUMO1 [nucleoplasm]
(R-HSA-4341057)
K389-THRA-G97-SUMO1 [nucleoplasm]
(R-HSA-4719415)
K283-THRA-G97-SUMO1 [nucleoplasm]
(R-HSA-4719434)
K399-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341020)
K428-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341035)
K494-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341093)
K89-NR3C2-G97-SUMO1 [nucleoplasm]
(R-HSA-4341058)
K119-NR5A1-G97-SUMO1 [nucleoplasm]
(R-HSA-4546379)
K194-NR5A1-G97-SUMO1 [nucleoplasm]
(R-HSA-4546380)
NR2C1-G97-SUMO1 [nucleoplasm]
(R-HSA-4717492)
K303-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090373)
K266-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090359)
K302-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090363)
K299-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090349)
K268-ESR1-G97-SUMO1 [nucleoplasm]
(R-HSA-4090414)
K531-PGR-G97-SUMO1 [nucleoplasm]
(R-HSA-4341021)
K7-PGR-G97-SUMO1 [nucleoplasm]
(R-HSA-4341052)
K388-PGR-G97-SUMO1 [nucleoplasm]
(R-HSA-4341056)
K132-NR1H4-G97-SUMO1 [nucleoplasm]
(R-HSA-9610527)
NR1H4-G97-SUMO1 [nucleoplasm]
(R-HSA-4755434)
PPARG-G97-SUMO1 [nucleoplasm]
(R-HSA-4717445)
K395-PPARG-G97-SUMO1 [nucleoplasm]
(R-HSA-4717446)
PPARA-G97-SUMO1 [nucleoplasm]
(R-HSA-4341069)
K443-THRB-G97-SUMO1 [nucleoplasm]
(R-HSA-4719431)
K146-THRB-G97-SUMO1 [nucleoplasm]
(R-HSA-4719410)
K50-THRB-G97-SUMO1 [nucleoplasm]
(R-HSA-4719401)
RORA-G97-SUMO1 [nucleoplasm]
(R-HSA-4719426)
HIC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4570544)
TP53BP1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730731)
SP3-G97-SUMO1 [nucleoplasm]
(R-HSA-3730646)
K423-MITF-G97-SUMO1 [nucleoplasm]
(R-HSA-3730755)
K289-MITF-G97-SUMO1 [nucleoplasm]
(R-HSA-3730738)
K25-FOXL2-G97-SUMO1 [nucleoplasm]
(R-HSA-3968400)
K150-FOXL2-G97-SUMO1 [nucleoplasm]
(R-HSA-3968382)
K114-FOXL2-G97-SUMO1 [nucleoplasm]
(R-HSA-3968396)
HNRNPC-G97-SUMO1 [nucleoplasm]
(R-HSA-4570515)
K497-NOP58-G97-SUMO1 [nucleoplasm]
(R-HSA-4570504)
K467-NOP58-G97-SUMO1 [nucleoplasm]
(R-HSA-4570462)
DNMT3B-G97-SUMO1 [nucleoplasm]
(R-HSA-4655444)
DNMT3A-G97-SUMO1 [nucleoplasm]
(R-HSA-4655383)
DNMT1-G97-SUMO1 [nucleoplasm]
(R-HSA-4655358)
K84-CBX5-G97-SUMO1 [nucleoplasm]
(R-HSA-4615838)
K-CBX5-G97-SUMO1 [nucleoplasm]
(R-HSA-4615955)
K476-HDAC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4615867)
K444-HDAC1-G97-SUMO1 [nucleoplasm]
(R-HSA-4616028)
CBX4-G97-SUMO1 [nucleoplasm]
(R-HSA-4551756)
HDAC2-G97-SUMO1 [nucleoplasm]
(R-HSA-4616032)
SUZ12-G97-SUMO1 [nucleoplasm]
(R-HSA-4615961)
SATB1-G97-SUMO1 [nucleoplasm]
(R-HSA-4615877)
HDAC4-G97-SUMO1 [nucleoplasm]
(R-HSA-4615956)
K1971-CHD3-G97-SUMO1 [nucleoplasm]
(R-HSA-8956370)
HIST1H4-G97-SUMO1 [nucleoplasm]
(R-HSA-4570549)
BMI1-G97-SUMO1 [nucleoplasm]
(R-HSA-4551654)
TFAP2B-G97-SUMO1 [nucleoplasm]
(R-HSA-3730839)
TFAP2C-G97-SUMO1 [nucleoplasm]
(R-HSA-3730823)
TFAP2A-1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730825)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
RANGAP1-G97-SUMO1 [nucleoplasm]
(R-HSA-3730796)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
HERC2-SUMO1 [nucleoplasm]
(R-HSA-4551761)
0.688
4
UniProt:Q96KS0 EGLN2
1
EGLN2 [nucleoplasm]
(R-HSA-1234117)
0.683
3
UniProt:O00257 CBX4
2
CBX4 [nucleoplasm]
(R-HSA-389118)
SUMO1-K494-CBX4 [nucleoplasm]
(R-HSA-4551626)
0.674
15
UniProt:P41227 NAA10
0.667
3
UniProt:P40337-3 VHL
0.659
6
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.649
9
UniProt:Q92793 CREBBP
3
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.609
2
UniProt:P09467 FBP1
1
FBP1 [cytosol]
(R-HSA-70476)
0.602
5
UniProt:P14618-1 PKM
1
PKM-1 [cytosol]
(R-HSA-71667)
0.591
7
UniProt:P17861 XBP1
0.591
3
UniProt:Q16665 HIF1A
7
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
HN-HIF1A [cytosol]
(R-HSA-1234110)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.589
2
UniProt:P25789 PSMA4
2
PSMA4 [cytosol]
(R-HSA-68730)
PSMA4 [nucleoplasm]
(R-HSA-174324)
0.576
4
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.576
3
UniProt:MAFG Q9BRP3
0.557
3
UniProt:Q9UHD8-1 SEPTIN9
0.556
4
UniProt:Q13330 MTA1
2
SUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
MTA1 [nucleoplasm]
(R-HSA-3465550)
0.556
6
UniProt:O60224 SSX4
0.553
2
UniProt:O14818 PSMA7
2
PSMA7 [cytosol]
(R-HSA-68736)
PSMA7 [nucleoplasm]
(R-HSA-174351)
0.544
2
UniProt:Q8BIF2 RFOX3
0.544
2
UniProt:P40818 USP8
2
p-T945-USP8 [cytosol]
(R-HSA-1358714)
USP8 [cytosol]
(R-HSA-917720)
0.544
2
UniProt:P51450-2 Rorc
2
Rorc-2 [nucleoplasm]
(R-MMU-8949302)
Rorc [nucleoplasm]
(R-MMU-446177)
0.544
2
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.524
3
UniProt:P23771 GATA3
2
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
GATA3 [nucleoplasm]
(R-HSA-996768)
0.524
3
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.524
2
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.524
3
UniProt:Q5RIX9
1
e2f7 [nucleoplasm]
(R-DRE-6798305)
0.524
2
UniProt:P46531 NOTCH1
60
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
p-NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2159809)
p-NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902204)
NOTCH1 L1574P Extracellular Fragment [extracellular region]
(R-HSA-1485582)
NOTCH1 L1600P Extracellular Fragment [extracellular region]
(R-HSA-2681764)
NEXT1 P2474Afs*4 [plasma membrane]
(R-HSA-2902194)
NEXT1 Q2395* [plasma membrane]
(R-HSA-2902192)
NEXT1 Q2440* [plasma membrane]
(R-HSA-2902196)
NEXT1 P2514Rfs*4 [plasma membrane]
(R-HSA-2768989)
NICD1 Q2395* [cytosol]
(R-HSA-2902195)
NICD1 P2514Rfs*4 [cytosol]
(R-HSA-2768996)
NICD1 P2474Afs*4 [cytosol]
(R-HSA-2902193)
NICD1 Q2440* [cytosol]
(R-HSA-2902191)
NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2769013)
NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902208)
NICD1 Q2395* [nucleoplasm]
(R-HSA-2902201)
NICD1 Q2440* [nucleoplasm]
(R-HSA-2902200)
NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2768982)
NOTCH1 Q2395* Transmembrane Fragment [plasma membrane]
(R-HSA-1485596)
NOTCH1 Q2440* Transmembrane Fragment [plasma membrane]
(R-HSA-1485602)
NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2894873)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region]
(R-HSA-2220929)
p-NICD1 [nucleoplasm]
(R-HSA-1604444)
Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911426)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911415)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911503)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane]
(R-HSA-1911511)
Pre-NOTCH1 [endoplasmic reticulum membrane]
(R-HSA-157024)
17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467396)
19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467425)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane]
(R-HSA-1472872)
NOTCH1(1665-2555) [Golgi membrane]
(R-HSA-157092)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane]
(R-HSA-1983679)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane]
(R-HSA-1911512)
NOTCH1(1665-2555) [plasma membrane]
(R-HSA-157239)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region]
(R-HSA-1983670)
NOTCH1(1665-1720) [extracellular region]
(R-HSA-157654)
NOTCH1(1721-1753) [plasma membrane]
(R-HSA-157656)
NEXT1 [plasma membrane]
(R-HSA-157200)
NICD1 [cytosol]
(R-HSA-157634)
NICD1 [nucleoplasm]
(R-HSA-157939)
0.499
2
UniProt:Q61539
1
Esrrb [nucleoplasm]
(R-MMU-446173)
0.499
2
UniProt:O94888 UBXN7
1
UBXN7 [cytosol]
(R-HSA-8956071)
0.499
3
UniProt:Q9C0J9 BHLHE41
1
BHLHE41 [nucleoplasm]
(R-HSA-879703)
0.499
2
UniProt:Q99PV5 Bhlhe41
1
Bhlhe41 [nucleoplasm]
(R-MMU-879802)
0.499
3
UniProt:P84022 SMAD3
21
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.463
6
UniProt:P49407 ARRB1
5
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [cytosol]
(R-HSA-264470)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.463
3
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