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CUL2 [nucleoplasm]
Stable Identifier
R-HSA-1234126
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-2, CUL2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
CUL2 [nucleoplasm] (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
CUL2 [nucleoplasm] (Homo sapiens)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
CUL2 [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
CUL2 [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
CUL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13617 CUL2
Gene Names
CUL2
Chain
chain:1-745
Reference Genes
BioGPS Gene:8453 CUL2
COSMIC (genes):CUL2 CUL2
CTD Gene:8453 CUL2
dbSNP Gene:8453 CUL2
ENSEMBL:ENSG00000108094 CUL2
ENSEMBL:ENSG00000108094.17 CUL2
HGNC:2552 CUL2
KEGG Gene (Homo sapiens):8453 CUL2
Monarch:8453 CUL2
NCBI Gene:8453 CUL2
OMIM:603135 CUL2
UCSC:Q13617 CUL2
Reference Transcript
RefSeq:NM_001198778.1 CUL2
RefSeq:NM_003591.3 CUL2
RefSeq:NM_001198777.1 CUL2
RefSeq:XM_011519747.1 CUL2
RefSeq:NM_001198779.1 CUL2
Other Identifiers
11720418_a_at
11748246_a_at
16713264
203078_PM_at
203078_at
203079_PM_s_at
203079_s_at
3284883
3284884
3284885
3284886
3284887
3284888
3284891
3284894
3284895
3284897
3284901
3284902
3284903
3284904
3284905
3284906
3284907
3284908
3284909
3284910
3284911
3284912
3284913
3284914
3284917
3284918
3284920
3284921
3284922
3284923
3284924
37894_at
7933047
8453
A_24_P252794
GE59493
GO:0000082
GO:0000278
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005829
GO:0006511
GO:0012501
GO:0016567
GO:0016740
GO:0019005
GO:0023052
GO:0030163
GO:0030674
GO:0030891
GO:0031146
GO:0031461
GO:0031462
GO:0031625
GO:0036211
GO:0043226
GO:0044877
GO:0060090
GO:0097193
GO:0140096
Hs.82919.0.S3_3p_at
ILMN_1669252
PH_hs_0004743
TC10001173.hg
U83410_at
g4503162_3p_a_at
Participates
as a component of
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
G76-NEDD8-K689-CUL2 [cytosol]
CUL2 [cytosol]
Inferred To
Cul2 [nucleoplasm]
(Drosophila melanogaster)
Cul2 [nucleoplasm]
(Mus musculus)
Cul2 [nucleoplasm]
(Rattus norvegicus)
CUL2 [nucleoplasm]
(Bos taurus)
CUL2 [nucleoplasm]
(Canis familiaris)
CUL2 [nucleoplasm]
(Danio rerio)
CUL2 [nucleoplasm]
(Gallus gallus)
CUL2 [nucleoplasm]
(Sus scrofa)
cul-2 [nucleoplasm]
(Caenorhabditis elegans)
cul2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011518049.1
,
NP_003582.2
,
NP_001185706.1
,
NP_001185707.1
,
NP_001185708.1
OpenTargets
ENSG00000108094
GeneCards
Q13617
HPA
ENSG00000108094-CUL2
Ensembl
ENSP00000501215
,
ENST00000374751
,
ENST00000690393
,
ENSP00000510691
,
ENST00000673636
,
ENST00000691974
,
ENSP00000363881
,
ENSP00000363880
,
ENSP00000508908
,
ENSG00000108094
,
ENSP00000363883
,
ENSP00000414095
,
ENST00000421317
,
ENST00000374748
,
ENST00000374749
PRO
Q13617
Pharos - Targets
Q13617
PDB
6R6H
,
6R7F
,
5N4W
,
7PLO
,
6R7N
,
6R7I
,
4WQO
,
6R7H
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.886
17
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.806
8
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.802
10
UniProt:O94888 UBXN7
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.708
20
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.643
3
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.643
8
UniProt:Q86VP6 CAND1
5
CAND1 [nucleoplasm]
(R-HSA-8955089)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [cytosol]
(R-HSA-5691146)
0.641
3
UniProt:Q9BQ90 KLHDC3
1
KLHDC3 [cytosol]
(R-HSA-535552)
0.623
8
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
8
UniProt:Q04323 UBXN1
2
UBXN1 [cytosol]
(R-HSA-8850588)
UBXN1 [nucleoplasm]
(R-HSA-9707052)
0.527
3
UniProt:Q15048 LRRC14
1
LRRC14 [cytosol]
(R-HSA-9749455)
0.499
6
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