Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
VHL [nucleoplasm]
Stable Identifier
R-HSA-1234127
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of ubiquitinylation proteins (Homo sapiens)
PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40337 VHL
Gene Names
VHL
Chain
chain:1-213
Reference Genes
BioGPS Gene:7428 VHL
COSMIC (genes):VHL VHL
CTD Gene:7428 VHL
dbSNP Gene:7428 VHL
ENSEMBL:ENSG00000134086 VHL
HGNC:12687 VHL
KEGG Gene (Homo sapiens):7428 VHL
Monarch:7428 VHL
NCBI Gene:7428 VHL
OMIM:608537 VHL
UCSC:P40337 VHL
Reference Transcript
RefSeq:NM_198156.2 VHL
RefSeq:NM_000551.3 VHL
Other Identifiers
0002680100
0003830215
11748633_a_at
11752180_x_at
1559227_s_at
1668_s_at
16937571
1LM8
1LQB
1VCB
203844_at
2610335
2610337
2610338
2610339
2610340
2610342
2610344
2610345
2610346
2610347
2610348
2610349
2610350
2610351
2610352
2610353
2610354
31631
31632
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
40871_at
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5430
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
7428
8077779
8077781
A0A024R2F2
A0A0S2Z4K1
A_23_P132606
A_24_P134942
A_33_P3419938
AAA98614
AAB64200
AAH58831
AC034193
AF010238
AK315799
ALQ33844
ALQ33845
BAG38142
BC058831
CAA65343
CAB005430
CCDS2597
CCDS2598
CH471055
EAW64064
EAW64066
EAW64068
ENSG00000134086
ENSP00000256474
ENSP00000344757
ENST00000256474
ENST00000256474.2
ENST00000345392
ENST00000345392.2
EntrezGene:7428
EntrezGene:VHL
g4507890_3p_at
GE54104
GO:0000122
GO:0000902
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0006355
GO:0006464
GO:0006508
GO:0006950
GO:0007165
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0010629
GO:0016020
GO:0016567
GO:0019899
GO:0030154
GO:0030891
GO:0032991
GO:0034641
GO:0043066
GO:0043226
GO:0043687
GO:0045597
GO:0045893
GO:0046426
GO:0048856
GO:0050821
GO:0061418
GO:0061428
GO:0061630
HGNC:12687
HPA031631
HPA031632
Hs2.421597.1.A1_3p_s_at
ILMN_1738579
ILMN_1801984
ILMN_2376625
IPR002714
IPR022772
IPR024048
IPR024053
IPR036208
IPR037139
IPR037140
KU178386
KU178387
L15409
L15409_at
LRG_322
LRG_322t1
MIM:144700
MIM:171300
MIM:193300
MIM:263400
MIM:608537
NM_000551
NM_198156
NP_000542
NP_937799
PF01847
PF17211
PH_hs_0033268
TC03000055.hg
TC03002213.hg
U54612
UPI0000035C95
UPI00001E0587
VHL
VHL-201
VHL-202
X96489
Participant Of
input
PIAS4 SUMOylates VHL with SUMO1
hasComponent
VBC Complex [nucleoplasm]
Other forms of this molecule
SUMO1-K159,171,196-VHL [nucleoplasm]
VHL [cytosol]
Inferred To
VHL [nucleoplasm] (Bos taurus)
VHL [nucleoplasm] (Caenorhabditis elegans)
VHL [nucleoplasm] (Danio rerio)
VHL [nucleoplasm] (Drosophila melanogaster)
VHL [nucleoplasm] (Gallus gallus)
VHL [nucleoplasm] (Mus musculus)
VHL [nucleoplasm] (Rattus norvegicus)
VHL [nucleoplasm] (Sus scrofa)
VHL [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_937799.1
,
NP_000542.1
OpenTargets
ENSG00000134086
ZINC - Substances
VHL_HUMAN
GeneCards
P40337
ZINC target
P40337
PRO
P40337
ZINC - Predictions - Purchasable
VHL_HUMAN
Orphanet
15708
PDB
5NVY
,
4W9C
,
6GFX
,
5NVZ
,
4W9D
,
6GFY
,
4W9E
,
6GFZ
,
4W9F
,
6FMI
,
5NW0
,
5NVV
,
5NW1
,
5NVW
,
5NW2
,
5NVX
,
4WQO
,
6BVB
,
4W9K
,
3ZUN
,
1VCB
,
4W9L
,
6GMN
,
4AJY
,
6GMQ
,
4W9G
,
6FMJ
,
4W9H
,
6FMK
,
4W9I
,
4W9J
,
4AWJ
,
6GMR
,
4B95
,
3ZRF
,
5N4W
,
3ZTD
,
6GMX
,
3ZTC
,
3ZRC
,
4B9K
,
1LM8
,
5LLI
,
4BKS
,
5T35
,
4BKT
,
1LQB
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.957
20
UniProt:Q15370 ELOB
2
ELOB [cytosol]
(R-HSA-180551)
TCEB2 [nucleoplasm]
(R-HSA-112423)
0.928
11
UniProt:Q13617 CUL2
3
CUL2 [nucleoplasm]
(R-HSA-1234126)
CUL2 [cytosol]
(R-HSA-416982)
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
0.85
14
UniProt:Q15369 ELOC
2
ELOC [cytosol]
(R-HSA-180535)
TCEB1 [nucleoplasm]
(R-HSA-112422)
0.784
7
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.623
4
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.611
9
UniProt:P21980 TGM2
0.602
10
UniProt:Q99750 MDFI
0.556
3
UniProt:Q99814 EPAS1
5
2xHP-EPAS1 [cytosol]
(R-HSA-1234149)
EPAS1 [nucleoplasm]
(R-HSA-452560)
EPAS1 [cytosol]
(R-HSA-1234119)
2xHP-EPAS1 [nucleoplasm]
(R-HSA-1234151)
HN-EPAS1 [cytosol]
(R-HSA-1234112)
0.547
2
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.508
2
UniProt:P02751 FN1
8
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.499
2
UniProt:Q61221
7
2xHP-HIF1A [nucleoplasm]
(R-MMU-1234105)
HN-HIF1A [cytosol]
(R-MMU-1234110)
2xHP-HIF1A [cytosol]
(R-MMU-1234131)
HIF1A [cytosol]
(R-MMU-1234102)
phospho-p-Y565,S797-HIF1A [cytosol]
(R-MMU-9634700)
phospho-p-Y565-HIF1A [cytosol]
(R-MMU-8857584)
HIF1A [nucleoplasm]
(R-MMU-1234135)
0.499
3
UniProt:P08151 GLI1
9
GLI1 [ciliary base]
(R-HSA-5610357)
GLI1 [ciliary tip]
(R-HSA-5610360)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
GLI1 [cytosol]
(R-HSA-445457)
ub-GLI1 [cytosol]
(R-HSA-5635833)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
0.463
2
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
PRKCZ [cytosol]
(R-HSA-58218)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
PRKCZ [cell junction]
(R-HSA-2134483)
0.463
3
© 2019
Reactome